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Fosrenol (lanthanum) prevents the body from absorbing phosphate, allowing it to be removed from the body.
Fosrenol is used to lower phosphate levels in patients with end stage kidney disease. High levels of phosphate can make it hard for your body to absorb calcium, which can cause serious medical problems.
Fosrenol may also be used for purposes not listed in this medication guide.
You should not use Fosrenol if you have a bowel obstruction or severe constipation.
Before you take Fosrenol, tell your doctor if you have a stomach ulcer, ulcerative colitis, Crohn's disease, diabetes, any type of bowel obstruction, or a history of colon cancer or intestinal surgery.
The chewable tablet should be chewed completely before you swallow it.
Take this medicine with food or immediately after eating.
Tell your doctor about all other medicines you use, especially antibiotics, seizure medication, heart or blood pressure medication, or a blood thinner.
If you also take thyroid replacement medication, take it at least 2 hours before or after taking Fosrenol. Do not take thyroid medication and lanthanum carbonate at the same time.
Avoid taking an antacid within 2 hours before or after you take lanthanum carbonate. Some antacids can make it harder for your body to absorb lanthanum carbonate.
You should not use Fosrenol if you are allergic to lanthanum carbonate, or if you have:
a bowel obstruction or severe constipation.
To make sure Fosrenol is safe for you, tell your doctor if you have:
a stomach ulcer;
any type of bowel obstruction;
slow digestion or severe constipation;
a history of surgery on your stomach or intestines;
ulcerative colitis, Crohn's disease, diverticulitis;
a history of stomach or intestinal cancer;
diabetes; or
problems with your teeth.
If you need to have any type of x-ray or CT scan of your stomach area, tell the doctor ahead of time that you are using Fosrenol.
It is not known whether Fosrenol will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.
It is not known whether lanthanum carbonate passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Take Fosrenol exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Take Fosrenol with food or immediately after eating.
The chewable tablet should be chewed completely before you swallow it. Do not swallow whole. Tell your doctor if you have trouble chewing the tablet.
Sprinkle the oral powder into a small amount of applesauce or other soft food (oral powder will not dissolve in liquid). Swallow right away without chewing. Do not save the mixture for later use.
While using Fosrenol, you may need frequent blood tests.
Store at room temperature away from moisture and heat.
Usual Adult Dose for Hyperphosphatemia of Renal Failure:
Initial dose: 1500 mg orally daily; take in divided doses with meals
Titrate in increments of 750 mg/day every 2 to 3 weeks until an acceptable serum phosphate level is reached
Maximum dose: 4500 mg/day
Comments: Most patients will require daily doses between 1500 and 3000 mg to reduce plasma phosphate levels to less than 6 mg/dL.
Use: To reduce serum phosphate levels in patients with end stage renal disease.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Fosrenol can make it harder for your body to absorb other medicines you take by mouth.
If you also take thyroid medication, take it at least 2 hours before or 2 hours after you take Fosrenol.
If you take an antibiotic such as ciprofloxacin (Cipro) or levofloxacin (Levaquin), take the antibiotic at least 1 hour before or 4 hours after you take lanthanum carbonate.
Avoid taking an antacid within 2 hours before or 2 hours after you take Fosrenol.
It may be best to avoid taking any other medications by mouth for several hours before or after you take lanthanum carbonate.
Get emergency medical help if you have signs of an allergic reaction to Fosrenol: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
severe constipation; or
severe stomach cramps.
Common Fosrenol side effects may include:
upset stomach, stomach pain, nausea, vomiting;
constipation;
itching, rash; or
tooth injury while chewing the tablet.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor about all your current medicines, especially medicines that can cause constipation, such as:
heart or blood pressure medication (amlodipine, diltiazem, nifedipine, verapamil, and others);
narcotic pain medicine;
a diuretic or "water pill"; or
anti-diarrhea medicine.
Other drugs may interact with lanthanum carbonate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Fosrenol only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Fosrenol (www.drugs.com/fosrenol.html).
Note: This document contains side effect information about lanthanum carbonate. Some of the dosage forms listed on this page may not apply to the brand name Fosrenol.
Common side effects of Fosrenol include: dialysis graft complication, nausea, and vomiting. Other side effects include: dialysis graft occlusion, and abdominal pain. See below for a comprehensive list of adverse effects.
Applies to lanthanum carbonate: oral powder, oral tablet chewable
Along with its needed effects, lanthanum carbonate (the active ingredient contained in Fosrenol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking lanthanum carbonate:
Incidence not known
Get emergency help immediately if any of the following symptoms of overdose occur while taking lanthanum carbonate:
Symptoms of overdose
Some side effects of lanthanum carbonate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Incidence not known
Applies to lanthanum carbonate: oral powder for reconstitution, oral tablet chewable
The most common adverse reactions included nausea, vomiting, and abdominal pain.
Nausea, diarrhea, and vomiting occurred more frequently among patients taking the oral powder formulation than those receiving the chewable tablets (18% versus 7%).
Very common (10% or more): Nausea (up to 37%), vomiting (up to 27%), diarrhea (up to 24%), abdominal pain (up to 17%), constipation (up to 15%)
Common (1% to 10%): Dyspepsia, flatulence
Uncommon (0.1% to 1%): Gastroenteritis, eructation, indigestion, irritable bowel syndrome, dry mouth, stomatitis, loose stools, esophagitis, tooth disorder
Postmarketing reports: Tooth injury chewing the tablet, intestinal perforation, intestinal obstruction, ileus, subileus
Common (1% to 10%): Hypocalcemia
Uncommon (0.1% to 1%): Hypercalcemia, hyperglycemia, hyperphosphatemia, hypophosphatemia, anorexia, appetite increased, thirst
Common (1% to 10%): Bronchitis, rhinitis
Uncommon (0.1% to 1%): Laryngitis
Uncommon (0.1% to 1%): Hyperparathyroidism
Serum parathyroid concentrations may fluctuate depending on a patient's serum calcium, phosphate and vitamin D status. This drug has not been shown to have any direct effects on PTH secretion.
Postmarketing reports: Allergic skin reactions (skin rashes, urticaria, and pruritus)
The effects of this drug on the bones of patients undergoing dialysis have been evaluated in studies of up to 4.5 years duration. Compared with standard treatments including calcium carbonate, no differences in adverse effects on the musculoskeletal system, including fractures, were observed.
Uncommon (0.1% to 1%): Arthralgia, myalgia, osteoporosis
Uncommon (0.1% to 1%): Alopecia, increased sweating
Uncommon (0.1% to 1%): Vertigo, asthenia, fatigue, malaise
Uncommon (0.1% to 1%): Chest pain, peripheral edema
Uncommon (0.1% to 1%): Eosinophilia
Very common (10% or more): Headache (up to 22%)
Uncommon (0.1% to 1%): Dizziness, taste alteration
Very common (10% or more): Dialysis graft occlusion (up to 25%)
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Fosrenol (www.drugs.com/fosrenol.html).
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