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Fosrenol

Generic Name: lanthanum carbonate (LAN than um CAR bo nayt)
Brand Names: Fosrenol
Fosrenol (lanthanum carbonate) reduces phosphate levels in patients with end stage renal disease. Includes Fosrenol side effects, interactions and indications.
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Drug Information:
Fosrenol (lanthanum) prevents the body from absorbing phosphate, allowing it to be removed from the body. Fosrenol is used to lower phosphate levels in patients with end stage kidney disease. High levels of phosphate can make it hard for your body to absorb Calcium, which can cause serious medical problems. Fosrenol may also be used for purposes not listed in this medication guide. You should not use Fosrenol if you have a bowel obstruction or severe constipation. Before you take Fosrenol, tell your doctor if you have a stomach ulcer, ulcerative colitis, Crohn's disease, diabetes, any type of bowel obstruction, or a history of colon cancer or intestinal surgery. Learn more

Fosrenol Side Effects

Fosrenol Side Effects

Note: This document contains side effect information about lanthanum carbonate. Some of the dosage forms listed on this page may not apply to the brand name Fosrenol.

In Summary

Common side effects of Fosrenol include: dialysis graft complication, nausea, and vomiting. Other side effects include: dialysis graft occlusion, and abdominal pain. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to lanthanum carbonate: oral powder, oral tablet chewable

Along with its needed effects, lanthanum carbonate (the active ingredient contained in Fosrenol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lanthanum carbonate:

Incidence not known

  • Bloody, black, or tarry stools
  • bone pain
  • constipation, severe
  • difficulty having a bowel movement
  • itching skin or rash
  • loss of appetite
  • seizures
  • severe stomach pain, cramping, or burning
  • trouble breathing
  • unusual tiredness or weakness
  • vomiting of material that looks like coffee grounds, severe and continuous
  • vomiting, severe

Get emergency help immediately if any of the following symptoms of overdose occur while taking lanthanum carbonate:

Symptoms of overdose

  • Headache

Some side effects of lanthanum carbonate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Stomach pain

Incidence not known

  • Belching
  • heartburn
  • indigestion
  • stomach discomfort or upset
  • tooth injury

For Healthcare Professionals

Applies to lanthanum carbonate: oral powder for reconstitution, oral tablet chewable

General

The most common adverse reactions included nausea, vomiting, and abdominal pain.

Gastrointestinal

Nausea, diarrhea, and vomiting occurred more frequently among patients taking the oral powder formulation than those receiving the chewable tablets (18% versus 7%).

Very common (10% or more): Nausea (up to 37%), vomiting (up to 27%), diarrhea (up to 24%), abdominal pain (up to 17%), constipation (up to 15%)

Common (1% to 10%): Dyspepsia, flatulence

Uncommon (0.1% to 1%): Gastroenteritis, eructation, indigestion, irritable bowel syndrome, dry mouth, stomatitis, loose stools, esophagitis, tooth disorder

Postmarketing reports: Tooth injury chewing the tablet, intestinal perforation, intestinal obstruction, ileus, subileus

Metabolic

Common (1% to 10%): Hypocalcemia

Uncommon (0.1% to 1%): Hypercalcemia, hyperglycemia, hyperphosphatemia, hypophosphatemia, anorexia, appetite increased, thirst

Respiratory

Common (1% to 10%): Bronchitis, rhinitis

Uncommon (0.1% to 1%): Laryngitis

Endocrine

Uncommon (0.1% to 1%): Hyperparathyroidism

Serum parathyroid concentrations may fluctuate depending on a patient's serum calcium, phosphate and vitamin D status. This drug has not been shown to have any direct effects on PTH secretion.

Hypersensitivity

Postmarketing reports: Allergic skin reactions (skin rashes, urticaria, and pruritus)

Musculoskeletal

The effects of this drug on the bones of patients undergoing dialysis have been evaluated in studies of up to 4.5 years duration. Compared with standard treatments including calcium carbonate, no differences in adverse effects on the musculoskeletal system, including fractures, were observed.

Uncommon (0.1% to 1%): Arthralgia, myalgia, osteoporosis

Dermatologic

Uncommon (0.1% to 1%): Alopecia, increased sweating

Other

Uncommon (0.1% to 1%): Vertigo, asthenia, fatigue, malaise

Cardiovascular

Uncommon (0.1% to 1%): Chest pain, peripheral edema

Hematologic

Uncommon (0.1% to 1%): Eosinophilia

Nervous system

Very common (10% or more): Headache (up to 22%)

Uncommon (0.1% to 1%): Dizziness, taste alteration

Renal

Very common (10% or more): Dialysis graft occlusion (up to 25%)

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Fosrenol (www.drugs.com/fosrenol.html).