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Folotyn

Generic Name: pralatrexate (PRAL a TREX ate)
Brand Names: Folotyn
Folotyn is used to treat T-cell lymphoma that has spread throughout the body. Learn about side effects, interactions and indications.
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Drug Information:
Folotyn (pralatrexate) is a cancer medication. Folotyn is used to treat T-cell lymphoma that has spread throughout the body. It is given for relapsed T-cell lymphoma, or after other medications have been tried without successful treatment. Folotyn may also be used for purposes not listed in this medication guide. Before you receive Folotyn, tell your doctor if you have kidney disease. Folotyn can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches). Learn more

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Folotyn Side Effects

Note: This document contains side effect information about pralatrexate. Some of the dosage forms listed on this page may not apply to the brand name Folotyn.

For the Consumer

Applies to pralatrexate: intravenous solution

Along with its needed effects, pralatrexate (the active ingredient contained in Folotyn) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking pralatrexate:

More common

  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • body aches or pain
  • chills
  • convulsions
  • cough
  • cracked lips
  • decreased urine
  • diarrhea
  • difficult or labored breathing
  • difficulty with swallowing
  • dry mouth
  • ear congestion
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • headache
  • increased thirst
  • loss of appetite
  • loss of voice
  • lower back or side pain
  • mood changes
  • muscle pain or cramps
  • nasal congestion
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • runny nose
  • shortness of breath
  • sneezing
  • sore throat
  • sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  • swelling
  • tightness in the chest
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Some side effects of pralatrexate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal or stomach pain
  • back pain
  • bloody nose
  • constipation
  • itching skin
  • lack or loss of strength
  • night sweats
  • pain in the arms or legs
  • rash
  • weight loss

For Healthcare Professionals

Applies to pralatrexate: intravenous solution

Gastrointestinal

Very common (10% or more): Mucositis (70%), nausea (40%), constipation (33%), vomiting (25%), diarrhea (21%), anorexia (15%)

Hematologic

Very common (10% or more): Thrombocytopenia (41%), anemia (34%), neutropenia (24%), leukopenia (11%)

Common (1% to 10%): Febrile neutropenia, pancytopenia

General

The most common side effects observed in patients with peripheral T-cell lymphoma (PTCL) were mucositis, thrombocytopenia, nausea, and fatigue.

Cardiovascular

Very common (10% or more): Edema (30%), tachycardia (10%)

Uncommon (0.1% to 1%): Cardiopulmonary arrest

Respiratory

Very common (10% or more): Cough (28%), epistaxis (26%), dyspnea (19%), upper respiratory tract infection (10%)

Metabolic

Very common (10% or more): Hypokalemia (15%)

Common (1% to 10%): Dehydration

Dermatologic

Very common (10% or more): Rash (15%), pruritus (14%)

Frequency not reported: Skin exfoliation, ulceration, toxic epidermal necrolysis

Other

Very common (10% or more): Fatigue (36%), pyrexia (32%), pharyngolaryngeal pain (14%), abdominal pain (12%), pain in extremity (12%), back pain (11%), night sweats (11%), asthenia (10%)

Hepatic

Very common (10% or more): Abnormal liver function tests (13%)

Immunologic

Common (1% to 10%): Sepsis

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Folotyn (www.drugs.com/folotyn.html).