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Focalin xr Prescription
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Generic Name: dexmethylphenidate (dex METH il FEN i date)
Brand Names: Focalin, Focalin XR
Focalin (dexmethylphenidate) is used to treat attention deficit hyperactivity disorder (ADHD). Includes Focalin side effects ,interactions and indications.
Generic Name: dexmethylphenidate (dex METH il FEN i date)
Brand Names: Focalin, Focalin XR
Focalin (dexmethylphenidate) is used to treat attention deficit hyperactivity disorder (ADHD). Includes Focalin side effects ,interactions and indications.
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30 tablets of Focalin Xr 40 mg
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Focalin Xr Drug Information:

Focalin (dexmethylphenidate) is a mild stimulant to the central nervous system. It affects chemicals in the brain that contrIbute to hyperactivity and impulse control. Focalin is used to treat attention deficit hyperactivity disorder (ADHD). Focalin may also be used for purposes not listed in this medication guide. Do not use Focalin if you have used a MAO inhibitor in the past 14 days, such as isocarboxazid, Linezolid, phenelzine, rasagiline, selegiline, tranylcypromine, or Methylene Blue injection. Learn more

Focalin Xr Side Effects

Note: This document contains side effect information about dexmethylphenidate. Some of the dosage forms listed on this page may not apply to the brand name Focalin.

In Summary

More frequent side effects include: fever. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dexmethylphenidate: oral capsule extended release, oral tablet


Oral route (Capsule, Extended Release; Tablet)

Give cautiously to patients with a history of drug dependence or alcoholism. Chronic, abusive use can lead to marked tolerance and psychological dependence with varying degrees of abnormal behavior. Frank psychotic episodes can occur, especially with parenteral abuse. Careful supervision is required during drug withdrawal from abusive use since severe depression may occur.

Along with its needed effects, dexmethylphenidate (the active ingredient contained in Focalin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dexmethylphenidate:

Less common

  • Fast, pounding, or irregular heartbeat


  • Blurred vision
  • vision changes

Incidence not known

  • Convulsions
  • jerking of the arms and legs
  • muscle spasm
  • sudden loss of consciousness

Some side effects of dexmethylphenidate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acid or sour stomach
  • belching
  • heartburn
  • indigestion
  • loss of appetite
  • nausea
  • stomach discomfort, upset, or pain
  • throat pain
  • weight loss

Less common

  • Twitching

For Healthcare Professionals

Applies to dexmethylphenidate: oral capsule extended release, oral tablet


The most commonly reported adverse reactions have included dyspepsia, decreased appetite, headache, and anxiety.


Frequency not reported: Angina, arrhythmia, palpitations, increased or decreased pulse, tachycardia, increased or decreased blood pressure, cerebral arteritis and/or occlusion

Postmarketing reports: Peripheral vasculopathy (including Raynaud's phenomenon)


Very common (10% or more): Psychiatric disorders (up to 46%), insomnia (up to 17%), feeling jittery (up to 12%), anxiety (up to 11%)

Common (1% to 10%): Depression, mood swings, irritability

Frequency not reported: Transient depressed mood, aggressive behavior, libido changes, restlessness, agitation, psychosis

Nervous system

Very common (10% or more): Nervous system disorders (up to 50%), headache (up to 39%)

Common (1% to 10%): Dizziness

Frequency not reported: Drowsiness, dyskinesia, headache, Tourette's syndrome, serotonin syndrome (in combination with serotonergic drugs)


Frequency not reported: Hypersensitivity reactions (including angioedema, anaphylaxis)


Frequency not reported: Arthralgia, muscle cramps

Postmarketing reports: Rhabdomyolysis


Very common (10% or more): GI disorders (up to 44%), dry mouth (up to 20%), abdominal pain (up to 15%)

Common (1% to 10%): Dyspepsia, nausea, vomiting

Frequency not reported: Dry mouth


Very common (10% or more): Metabolism/nutrition disorders (up to 34%), decreased appetite (up to 30%)

Common (1% to 10%): Anorexia

Frequency not reported: Weight loss during prolonged therapy, reduced weight gain, growth suppression during prolonged use in pediatric patients


Very common (10% or more): Respiratory/thoracic/mediastinal disorders (up to 16%)

Common (1% to 10%): Nasal congestion, pharyngolaryngeal pain

Frequency not reported: Nasopharyngitis, cough


Common (1% to 10%): Pruritus

Frequency not reported: Scalp hair loss, hyperhidrosis, pruritus, urticaria, exfoliative dermatitis, erythema multiforme rash, thrombocytopenic purpura


Common (1% to 10%): Fever



Frequency not reported: Priapism


Frequency not reported: Leukopenia, thrombocytopenia, anemia


Frequency not reported: Abnormal liver function ranging from transaminase elevation to severe hepatic injury


Frequency not reported: Blurred vision, difficulties in visual accommodation

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.

Source: Drugs.com Focalin Xr (www.drugs.com/focalin.html).