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Flutamide is an antiandrogen. It works in the body to prevent the actions of androgens (male hormones).
Flutamide is used together with another hormone to treat prostate cancer.
Flutamide may also be used for purposes not listed in this medication guide.
Flutamide can cause serious liver problems. Call your doctor at once if you have upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).
You will need frequent blood tests to check your liver function while you are taking flutamide.
You should not use flutamide if you are allergic to flutamide.
Flutamide should never be taken by a woman or a child.
Although flutamide is not for use by women, this medicine can cause birth defects if a woman is exposed to it during pregnancy.
To make sure flutamide is safe for you, tell your doctor if you have:
liver disease;
a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency
hemoglobin M disease;
if you smoke; or
if you also take a blood thinner (warfarin, Coumadin, Jantoven).
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Flutamide is usually taken every 8 hours. Follow your doctor's instructions.
Call your doctor if you have severe or ongoing diarrhea. Your doctor may recommend an anti-diarrhea medicine.
Drink plenty of liquids while you are taking flutamide. Your doctor may recommend a special diet to help prevent diarrhea.
While using flutamide, you may need frequent blood tests.
Flutamide is given as part of a combination prostate cancer treatment with another medicine called a luteinizing (LOO-tee-in-ize-ing) hormone-releasing hormone, or LHRH. These medicines prevent the testicles from producing testosterone.
You should not stop using flutamide suddenly. Stopping suddenly may make your condition worse.
Store at room temperature away from moisture, heat, and light.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Call your doctor for instructions if you miss an appointment for your LHRH injection.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
To help prevent diarrhea, avoid dairy products such as milk, cheese, and yogurt. Do not use laxatives while taking flutamide.
flutamide can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Flutamide can cause serious liver problems. Call your doctor at once if you have:
nausea, upper stomach pain, loss of appetite;
itching, tired feeling, flu-like symptoms;
dark urine, clay-colored stools; or
jaundice (yellowing of the skin or eyes).
Common side effects may include:
breast swelling or tenderness;
hot flashes;
vomiting, diarrhea; or
impotence, loss of interest in sex.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Prostate Cancer:
250 mg orally every 8 hours
Comments:
-This drug may be taken with or without food.
-Stage B2-C Prostatic Carcinoma: Treatment with this drug and the goserelin acetate implant starting 8 weeks prior to initiating radiation therapy and continue during radiation therapy.
-Stage D2 Metastatic Carcinoma: This drug should be initiated with the LHRH-agonist and continued until progression.
Use: Locally confined Stage B2-C and Stage D2 metastatic carcinoma of the prostate
Other drugs may interact with flutamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Flutamide (www.drugs.com/mtm/flutamide.html).
Commonly reported side effects of flutamide include: diarrhea. See below for a comprehensive list of adverse effects.
Applies to flutamide: oral capsule
Oral route (Capsule)
Liver failure has been reported in patients taking flutamide. Evidence of hepatic injury occurred usually within the first 3 months and included elevated serum transaminase levels, jaundice, hepatic encephalopathy, and death related to acute hepatic failure. Serum transaminase levels should be measured prior to starting treatment, monthly for the first 4 months of therapy, and periodically thereafter. Flutamide is not recommended in patients whose ALT values exceed twice the upper limit of normal and should be discontinued if the ALT rises above 2 times the upper limit of normal or jaundice occurs during therapy.
Along with its needed effects, flutamide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking flutamide:
More common
Less common
Rare
Incidence not known
Get emergency help immediately if any of the following symptoms of overdose occur while taking flutamide:
Symptoms of overdose
Some side effects of flutamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Applies to flutamide: oral capsule
Rare (0.01% to 0.1%): Abnormal liver function tests, hepatic dysfunction, jaundice
Very rare (less than 0.01%): Cholestatic jaundice, hepatic encephalopathy, liver cell necrosis, fatal hepatotoxicity
Rare (0.01% to 0.1%): Anemia, leucopenia, thrombocytopenia
Very rare (less than 0.01%): Hemolytic anemia, megalocytic anemia, methemoglobinemia, sulfhemoglobinemia, macrocytic anemia
Rare (less than 0.1%): Dizziness, headache, numbness, drowsiness
Frequency not reported: Tiredness, malaise
Very common (10% or more): Hot flushes
Rare (less than 0.1%): Cardiovascular disorders, hypertension, lymphoedema
Frequency not reported: QT prolongation, thromboembolism
Rare (0.01% to 0.1%): Urticaria, pruritus, ecchymosis, alteration of the hair growth pattern and loss of hair (head), rash
Very rare (less than 0.01%): Photosensitivity reactions, erythema, ulcers, bullous eruptions, epidermal necrosis
Very common (10% or more): Gynecomastia (19%)
Common (1% to 10%): Breast tenderness (7%)
Very common (10% or more): Nausea, vomiting, diarrhea
Rare (less than 0.1%): Constipation, ulcer-like pain, dyspepsia, colitis, upset stomach, heartburn, abdominal pain
Rare (0.01% to 0.1%): Muscle cramps, neuromuscular symptoms, reduced bone mineral density, osteoporotic disorders, arthralgia, myalgia
Rare (0.01% to 0.1%): Anxiety, depression, confusion, nervousness
Frequency not reported: Loss of libido
Rare (0.01% to 0.1%): Interstitial pneumonitis, dyspnea
Very rare (less than 0.01%): Cough, interstitial lung disease
Rare (0.01% to 0.1%): Lupus-like syndrome
Very rare (less than 0.01%): Herpes zoster
Rare (less than 0.1%): Blurred vision
Common (1% to 10%): Increased appetite
Rare (less than 0.1%): Anorexia
Very rare (less than 0.01%): Neoplasm of the male breast
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Flutamide (www.drugs.com/mtm/flutamide.html).
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