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Commonly reported side effects of flutamide include: diarrhea. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to flutamide: oral capsule
Oral route (Capsule)
Liver failure has been reported in patients taking flutamide. Evidence of hepatic injury occurred usually within the first 3 months and included elevated serum transaminase levels, jaundice, hepatic encephalopathy, and death related to acute hepatic failure. Serum transaminase levels should be measured prior to starting treatment, monthly for the first 4 months of therapy, and periodically thereafter. Flutamide is not recommended in patients whose ALT values exceed twice the upper limit of normal and should be discontinued if the ALT rises above 2 times the upper limit of normal or jaundice occurs during therapy.
Along with its needed effects, flutamide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking flutamide:
More common
Less common
Rare
Incidence not known
Get emergency help immediately if any of the following symptoms of overdose occur while taking flutamide:
Symptoms of overdose
Some side effects of flutamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
For Healthcare Professionals
Applies to flutamide: oral capsule
HepaticRare (0.01% to 0.1%): Abnormal liver function tests, hepatic dysfunction, jaundice
Very rare (less than 0.01%): Cholestatic jaundice, hepatic encephalopathy, liver cell necrosis, fatal hepatotoxicity
HematologicRare (0.01% to 0.1%): Anemia, leucopenia, thrombocytopenia
Very rare (less than 0.01%): Hemolytic anemia, megalocytic anemia, methemoglobinemia, sulfhemoglobinemia, macrocytic anemia
Nervous systemRare (less than 0.1%): Dizziness, headache, numbness, drowsiness
Frequency not reported: Tiredness, malaise
CardiovascularVery common (10% or more): Hot flushes
Rare (less than 0.1%): Cardiovascular disorders, hypertension, lymphoedema
Frequency not reported: QT prolongation, thromboembolism
DermatologicRare (0.01% to 0.1%): Urticaria, pruritus, ecchymosis, alteration of the hair growth pattern and loss of hair (head), rash
Very rare (less than 0.01%): Photosensitivity reactions, erythema, ulcers, bullous eruptions, epidermal necrosis
EndocrineVery common (10% or more): Gynecomastia (19%)
Common (1% to 10%): Breast tenderness (7%)
GastrointestinalVery common (10% or more): Nausea, vomiting, diarrhea
Rare (less than 0.1%): Constipation, ulcer-like pain, dyspepsia, colitis, upset stomach, heartburn, abdominal pain
MusculoskeletalRare (0.01% to 0.1%): Muscle cramps, neuromuscular symptoms, reduced bone mineral density, osteoporotic disorders, arthralgia, myalgia
PsychiatricRare (0.01% to 0.1%): Anxiety, depression, confusion, nervousness
GenitourinaryFrequency not reported: Loss of libido
RespiratoryRare (0.01% to 0.1%): Interstitial pneumonitis, dyspnea
Very rare (less than 0.01%): Cough, interstitial lung disease
ImmunologicRare (0.01% to 0.1%): Lupus-like syndrome
Very rare (less than 0.01%): Herpes zoster
OcularRare (less than 0.1%): Blurred vision
MetabolicCommon (1% to 10%): Increased appetite
Rare (less than 0.1%): Anorexia
OncologicVery rare (less than 0.01%): Neoplasm of the male breast
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Flutamide (www.drugs.com/mtm/flutamide.html).
June 22, 2021
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