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Flumazenil Prescription
Generic Name: flumazenil (floo MAZ e nil)
Brand Name: Romazicon
Physician reviewed flumazenil patient information - includes flumazenil description, dosage and directions.
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Flumazenil Drug Information:

Flumazenil reverses the effects of benzodiazepine (BENZ-oh-dye-AYZ-e-peen) sedatives such as Valium, Versed, Xanax, Tranxene, and others. Benzodiazepines are sometimes used as sedatives before surgery or other medical procedures. Flumazenil is used to reverse benzodiazepine sedation to help you wake up after your medical procedure. Flumazenil is also used to treat benzodiazepine overdose in adults. Flumazenil may also be used for purposes not listed in this medication guide. Flumazenil may cause seizures (convulsions), especially in people who have sedative-addiction withdrawal symptoms or recent antidepressant overdose, people who have recently received injectable benzodiazepines, or people who had symptoms of a seizure just before receiving flumazenil. Talk to your doctor if you have concerns about the risk of seizure. Learn more

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Flumazenil Side Effects

In Summary

Commonly reported side effects of flumazenil include: dizziness, nausea, and vomiting. Other side effects include: headache, agitation, depersonalization, depression, dysphoria, dyspnea, euphoria, hyperventilation, insomnia, nervousness, palpitations, paranoid ideation, paresthesia, tremor, uncontrolled crying, visual disturbance, diaphoresis, pain at injection site, and xerostomia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to flumazenil: parenteral injection

Side effects include:

Dizziness, injection site pain, increased sweating, headache, and abnormal or blurred vision.

For Healthcare Professionals

Applies to flumazenil: intravenous solution

Nervous system

Very common (10% or more): Dizziness (vertigo, ataxia) (10%)

Common (1% to 10%): Headache, paresthesia (sensation abnormal, hypoesthesia)

Frequency not reported: Convulsions, somnolence, speech disorder (dysphonia, thick tongue)

Convulsions have occurred in patients with severe hepatic impairment, inpatients relying on benzodiazepine effects to control seizures, patients physically dependent on benzodiazepines, and those who have ingested large doses of other drugs (mixed-drug overdose).


Common (1% to 10%): Agitation (anxiety, nervousness, dry mouth, tremor, palpitations, insomnia, dyspnea, hyperventilation), emotional lability (crying abnormal, depersonalization, euphoria, increased tears, depression, dysphoria, paranoia)

Frequency not reported: Confusion (difficulty concentrating, delirium)

Postmarketing reports: Fear, panic attacks in patients with a history of panic disorders


Common (1% to 10%): Cutaneous vasodilation (sweating, flushing, hot flushes)

Uncommon (0.1% to 1%): Cardiac dysrhythmias (ventricular tachycardia, junctional tachycardia)

Frequency not reported: Arrhythmia (atrial, nodal, ventricular extrasystoles), bradycardia, tachycardia, hypertension, chest pain


The majority of deaths occurred in patients with serious underlying disease or in patients who had injects large amounts of non-benzodiazepine drugs (usually cyclic antidepressants) as part of an overdose.

Withdrawal symptoms may occur after rapid injection of flumazenil in patients with long term exposure to benzodiazepines.

Common (1% to 10%): Fatigue (asthenia, malaise)

Frequency not reported: Death, abnormal hearing (transient hearing impairment, hyperacusis, tinnitus), rigors, shivering

Postmarketing reports: Withdrawal symptoms


Common (1% to 10%): Injection site pain, injection site reaction (thrombophlebitis, skin abnormality, rash)


Common (1% to 10%): Abnormal vision (visual field defect, diplopia)


Frequency not reported: Hiccup

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Flumazenil (www.drugs.com/mtm/flumazenil.html).