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Flumadine

Generic Name: rimantadine (ri MAN ta deen)
Brand Name: Flumadine
Physician reviewed Flumadine patient information - includes Flumadine description, dosage and directions.
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Drug Information:
Flumadine is an antiviral medicine used to treat or prevent influenza A in people who are at least 17 years old. This medicine is also used to prevent influenza A in children ages 1 to 16 years old. Flumadine may not be effective during every flu season because certain strains of the virus may be resistant to Flumadine. This medicine should not be used in place of getting a yearly flu shot. The Centers for Disease Control recommends an annual flu shot to help protect you each year from new strains of influenza virus. Learn more

Flumadine Side Effects

Flumadine Side Effects

Note: This document contains side effect information about rimantadine. Some of the dosage forms listed on this page may not apply to the brand name Flumadine.

For the Consumer

Applies to rimantadine: oral tablet

Along with its needed effects, rimantadine (the active ingredient contained in Flumadine) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rimantadine:

Less common

  • Difficult or labored breathing
  • shortness of breath
  • tightness in the chest
  • wheezing

Get emergency help immediately if any of the following symptoms of overdose occur while taking rimantadine:

Symptoms of overdose

  • Anxiety
  • chest pain or discomfort
  • dizziness
  • dry mouth
  • fainting
  • fast, slow, or irregular heartbeat
  • hyperventilation
  • irregular heartbeats
  • irritability
  • lightheadedness
  • nervousness
  • pounding or rapid pulse
  • restlessness
  • seeing, hearing, or feeling things that are not there
  • shaking
  • trouble with sleeping

Some side effects of rimantadine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Abdominal or stomach pain
  • acid or sour stomach
  • belching
  • continuing ringing or buzzing or other unexplained noise in the ears
  • diarrhea
  • difficulty with concentrating
  • headache
  • hearing loss
  • heartburn
  • impaired concentration
  • indigestion
  • lack or loss of strength
  • loss of appetite
  • nausea
  • rash
  • shakiness and unsteady walk
  • sleepiness or unusual drowsiness
  • stomach discomfort, upset, or pain
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual tiredness or weakness
  • vomiting

For Healthcare Professionals

Applies to rimantadine: oral syrup, oral tablet

General

The more commonly reported adverse effects have included gastrointestinal and nervous system side effects.

Nervous system

Common (1% to 10%): Dizziness, headache, jitteriness

Uncommon (0.1% to 1%): Ataxia, somnolence

Frequency not reported: Gait abnormality, hyperkinesia, tremor, taste loss/change, parosmia, convulsions, hypesthesia

Gait abnormality, hyperkinesia, tremor, taste loss/change, parosmia, and convulsions have been reported in less than 0.3% of patients. Hypesthesia has occurred with higher than recommended doses. Dizziness and headache were reported up to two times more often in geriatric patients receiving rimantadine than in those receiving placebo. Seizures were reported in a few patients during clinical trials with rimantadine. In two patients, seizure activity had been absent for greater than 10 years. However, their anticonvulsant medications had been withdrawn in the previous few months.

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, anorexia, dry mouth, abdominal pain

Uncommon (0.1% to 1%): Diarrhea, dyspepsia

Frequency not reported: Constipation, dysphagia, stomatitis

Constipation, dysphagia, and stomatitis have occurred with higher than recommended doses of rimantadine. Gastrointestinal symptoms (particularly nausea, vomiting, and abdominal pain) were reported at least twice as often in geriatric patients receiving rimantadine than in those receiving placebo. Tolerance may be improved by giving the drug in two divided daily doses.

Psychiatric

Common (1% to 10%): Insomnia, impaired concentration, nervousness, depression

Uncommon (1% to 10%): Agitation

Frequency not reported: Hallucinations, euphoria, anxiety, confusion

Cardiovascular

Frequency not reported: Cardiac failure, cerebrovascular disorder, heart block, hypertension, palpitation, pedal edema, tachycardia, syncope

Cardiac failure, cerebrovascular disorder, heart block, hypertension, palpitation, pedal edema, tachycardia, and syncope were reported in less than 0.3% of patients.

Respiratory

Uncommon (0.1% to 1%): Dyspnea

Frequency not reported: Bronchospasm, cough

Other

Common (1% to 10%): Asthenia, fatigue

Uncommon (0.1% to 1%): Tinnitus

Frequency not reported: Fever, rigors

Dermatologic

Uncommon (0.1% to 1%): Diaphoresis, rash

Genitourinary

Frequency not reported: Nonpuerperal lactation, increased micturition frequency

Genitourinary side effects have included nonpuerperal lactation in less than 0.3% of patients. Increased micturition frequency has occurred with higher than recommended doses of rimantadine.

Ocular

Frequency not reported: Lacrimation, eye pain

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Flumadine (www.drugs.com/mtm/flumadine.html).