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Flucytosine Prescription
Generic Name: flucytosine (floo SYE toe seen)
Brand Name: Ancobon
Physician reviewed flucytosine patient information - includes flucytosine description, dosage and directions.
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Flucytosine Drug Information:

Flucytosine is an antifungal medication that fights infections caused by fungus. Flucytosine is used to treat serious fungal infections of the blood, lungs, heart, central nervous system, and urinary tract. Flucytosine is sometimes given with another medicine called Amphotericin B. Flucytosine may also be used for purposes not listed in this medication guide. Before you take flucytosine, tell your doctor if you have kidney disease. You should not use flucytosine if you are allergic to it. To make sure flucytosine is safe for you, tell your doctor if you have: Learn more

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Flucytosine Side Effects

For the Consumer

Applies to flucytosine: oral capsule


Oral route (Capsule)

Use with extreme caution in patients with impaired renal function. Close monitoring of hematologic, renal, and hepatic status of all patients is essential.

Along with its needed effects, flucytosine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking flucytosine:

More common

  • Skin rash, redness, or itching
  • sore throat and fever
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • yellow eyes or skin

Less common

  • Confusion
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • increased sensitivity of skin to sunlight

Some side effects of flucytosine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal pain
  • diarrhea
  • loss of appetite
  • nausea or vomiting

Less common

  • Dizziness or lightheadedness
  • drowsiness
  • headache

For Healthcare Professionals

Applies to flucytosine: oral capsule


Frequency not reported: Cardiac arrest, myocardial toxicity, ventricular dysfunction, cardiac toxicity with ST elevation


Frequency not reported: Rash, pruritus, urticaria, photosensitivity, Lyell's syndrome


Frequency not reported: Nausea, vomiting/emesis, abdominal pain, diarrhea, dry mouth, duodenal ulcer, gastrointestinal hemorrhage/bleeding, enterocolitis, ulcerative colitis


Frequency not reported: Crystalluria


Frequency not reported: Anemia, agranulocytosis, aplastic anemia, eosinophilia, leukopenia, pancytopenia, thrombocytopenia, bone marrow aplasia (fatal cases), bone marrow toxicity


Acute hepatic injury including hepatic necrosis with possible fatal outcome in debilitated patients has been reported.

Alterations in liver function tests were generally dose related and reversible.

Frequency not reported: Jaundice, hepatic dysfunction, elevated bilirubin, increased hepatic enzymes, acute hepatic injury, hepatic necrosis, hepatitis, alterations in liver function tests


Frequency not reported: Allergic reactions, anaphylaxis


Frequency not reported: Anorexia, hypoglycemia, hypokalemia

Nervous system

Frequency not reported: Ataxia, hearing loss, headache, paresthesia, parkinsonism, peripheral neuropathy, vertigo, sedation, convulsions


Frequency not reported: Pyrexia, fatigue, weakness


Frequency not reported: Confusion, hallucinations, psychosis


Frequency not reported: Azotemia, elevated creatinine, elevated BUN, renal failure


Frequency not reported: Dyspnea, chest pain, respiratory arrest

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Flucytosine (www.drugs.com/mtm/flucytosine.html).