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Applies to flucytosine: oral capsule
Oral route (Capsule)
Use with extreme caution in patients with impaired renal function. Close monitoring of hematologic, renal, and hepatic status of all patients is essential.
Along with its needed effects, flucytosine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking flucytosine:
Some side effects of flucytosine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
For Healthcare Professionals
Applies to flucytosine: oral capsuleCardiovascular
Frequency not reported: Cardiac arrest, myocardial toxicity, ventricular dysfunction, cardiac toxicity with ST elevationDermatologic
Frequency not reported: Rash, pruritus, urticaria, photosensitivity, Lyell's syndromeGastrointestinal
Frequency not reported: Nausea, vomiting/emesis, abdominal pain, diarrhea, dry mouth, duodenal ulcer, gastrointestinal hemorrhage/bleeding, enterocolitis, ulcerative colitisGenitourinary
Frequency not reported: CrystalluriaHematologic
Frequency not reported: Anemia, agranulocytosis, aplastic anemia, eosinophilia, leukopenia, pancytopenia, thrombocytopenia, bone marrow aplasia (fatal cases), bone marrow toxicityHepatic
Acute hepatic injury including hepatic necrosis with possible fatal outcome in debilitated patients has been reported.
Alterations in liver function tests were generally dose related and reversible.
Frequency not reported: Jaundice, hepatic dysfunction, elevated bilirubin, increased hepatic enzymes, acute hepatic injury, hepatic necrosis, hepatitis, alterations in liver function testsHypersensitivity
Frequency not reported: Allergic reactions, anaphylaxisMetabolic
Frequency not reported: Anorexia, hypoglycemia, hypokalemiaNervous system
Frequency not reported: Ataxia, hearing loss, headache, paresthesia, parkinsonism, peripheral neuropathy, vertigo, sedation, convulsionsOther
Frequency not reported: Pyrexia, fatigue, weaknessPsychiatric
Frequency not reported: Confusion, hallucinations, psychosisRenal
Frequency not reported: Azotemia, elevated creatinine, elevated BUN, renal failureRespiratory
Frequency not reported: Dyspnea, chest pain, respiratory arrest
December 16, 2020
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