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Applies to floxuridine: injection powder for solution
Injection route (Powder for Solution)
All patients should be hospitalized for initiation of the first course of therapy with floxuridine because of the possibility of severe toxic reactions.
Along with its needed effects, floxuridine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.
Check with your doctor immediately if any of the following side effects occur while taking floxuridine:
Some side effects of floxuridine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common or rare
This medicine sometimes causes temporary thinning of hair. After treatment with floxuridine has ended, normal hair growth should return.
Applies to floxuridine: injectable powder for injection
Frequency not reported: Fever, lethargy, malaise, weakness
-Adverse reactions to the arterial infusion of this drug are generally related to the procedural complications of regional arterial infusion. The complications include arterial aneurysm, arterial ischemia, arterial thrombosis, embolism, fibromyositis, thrombophlebitis, hepatic necrosis, abscesses, infection at the catheter site, bleeding at the catheter site and/or a blocked, leaking, or displaced catheter.
-Laboratory abnormalities include BSP, prothrombin, total proteins, sedimentation rate and thrombocytopenia.
Frequency not reported: Stomatitis, esophagopharyngitis (at the first visible sign), nausea, vomiting, diarrhea, enteritis, stomatitis, duodenal ulcer, duodenitis, gastritis, bleeding, gastroenteritis, glossitis, pharyngitis, anorexia, cramps, abdominal pain, possible intra- and extrahepatic biliary sclerosis, acalculous cholecystitis
Frequency not reported: Leukopenia (WBC under 3500) or a rapidly falling white blood count, anemia, leukopenia, thrombocytopenia, hemorrhage (from any site)
Frequency not reported: Elevations of alkaline phosphatase, serum transaminase, serum bilirubin, and lactic dehydrogenase
Frequency not reported: Alopecia, dermatitis, nonspecific skin toxicity, rash
Frequency not reported: Myocardial ischemia
Frequency not reported: Neurotoxicity
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