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Floxuridine

Generic Name: floxuridine (flox URE i deen)
Brand Name: FUDR
Physician reviewed floxuridine patient information - includes floxuridine description, dosage and directions.
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Drug Information:
FloxuRidine is a cancer medication that interferes with the growth and spread of cancer cells in the body. FloxuRidine is used in the treatment of digestive system cancers that have spread to the liver. FloxuRidine may also be used for purposes not listed in this medication guide. You should not use floxuRidine if you have an infection, bone marrow suppression, or if you are malnourished. Your doctor will want to give your first dose of floxuRidine in a hospital or clinic setting to quickly treat any serious side effects that occur. Learn more

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Floxuridine Side Effects

For the Consumer

Applies to floxuridine: injection powder for solution

Warning

Injection route (Powder for Solution)

All patients should be hospitalized for initiation of the first course of therapy with floxuridine because of the possibility of severe toxic reactions.

Along with its needed effects, floxuridine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Check with your doctor immediately if any of the following side effects occur while taking floxuridine:

More common

  • Diarrhea
  • sores in mouth and on lips
  • stomach pain or cramps

Less common

  • Black, tarry stools
  • heartburn
  • nausea and vomiting
  • scaling or redness of hands or feet
  • swelling or soreness of the tongue

Rare

  • Blood in urine or stools
  • cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • pinpoint red spots on skin
  • trouble in walking
  • unusual bleeding or bruising
  • yellow eyes or skin

Some side effects of floxuridine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

  • Loss of appetite
  • skin rash or itching

This medicine sometimes causes temporary thinning of hair. After treatment with floxuridine has ended, normal hair growth should return.

For Healthcare Professionals

Applies to floxuridine: injectable powder for injection

Other

Frequency not reported: Fever, lethargy, malaise, weakness

-Adverse reactions to the arterial infusion of this drug are generally related to the procedural complications of regional arterial infusion. The complications include arterial aneurysm, arterial ischemia, arterial thrombosis, embolism, fibromyositis, thrombophlebitis, hepatic necrosis, abscesses, infection at the catheter site, bleeding at the catheter site and/or a blocked, leaking, or displaced catheter.

-Laboratory abnormalities include BSP, prothrombin, total proteins, sedimentation rate and thrombocytopenia.

Gastrointestinal

Frequency not reported: Stomatitis, esophagopharyngitis (at the first visible sign), nausea, vomiting, diarrhea, enteritis, stomatitis, duodenal ulcer, duodenitis, gastritis, bleeding, gastroenteritis, glossitis, pharyngitis, anorexia, cramps, abdominal pain, possible intra- and extrahepatic biliary sclerosis, acalculous cholecystitis

Hematologic

Frequency not reported: Leukopenia (WBC under 3500) or a rapidly falling white blood count, anemia, leukopenia, thrombocytopenia, hemorrhage (from any site)

Hepatic

Frequency not reported: Elevations of alkaline phosphatase, serum transaminase, serum bilirubin, and lactic dehydrogenase

Dermatologic

Frequency not reported: Alopecia, dermatitis, nonspecific skin toxicity, rash

Cardiovascular

Frequency not reported: Myocardial ischemia

Nervous system

Frequency not reported: Neurotoxicity

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Floxuridine (www.drugs.com/mtm/floxuridine.html).