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Note: This document contains side effect information about levomilnacipran. Some of the dosage forms listed on this page may not apply to the brand name Fetzima.
In SummaryCommon side effects of Fetzima include: erectile dysfunction, nausea, and orthostatic hypotension. Other side effects include: constipation, ejaculatory disorder, epididymitis, increased heart rate, palpitations, premature ejaculation, sinus tachycardia, tachycardia, testicular pain, urinary hesitancy, vomiting, delayed ejaculation, ejaculation failure, and hyperhidrosis. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to levomilnacipran: oral capsule extended release
Oral route (Capsule, Extended Release)
Antidepressants can increase the risk of suicidal thinking and behavior in children, adolescents, and young adults; however, this risk was not observed in patients older than 24 years and risk was reduced in patients 65 years or older. Closely monitor patients of all ages for clinical worsening and for emergence of suicidal thoughts and behaviors. Not approved for use in pediatric patients.
Along with its needed effects, levomilnacipran (the active ingredient contained in Fetzima) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking levomilnacipran:
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Some side effects of levomilnacipran may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
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For Healthcare Professionals
Applies to levomilnacipran: oral capsule extended release
GeneralThe most commonly reported side effects were nausea, erectile dysfunction, constipation, and hyperhidrosis.
GastrointestinalVery common (10% or more): Nausea (up to 17%)
Common (1% to 10%): Constipation, vomiting
Frequency not reported: Abdominal pain, flatulence
GenitourinaryCommon (1% to 10%): Erectile dysfunction, ejaculation disorder, testicular pain, urinary hesitation
Frequency not reported: Delayed ejaculation, ejaculation failure, epididymitis, hematuria, organic erectile dysfunction, pollakiuria, premature ejaculation, proteinuria, psychogenic erectile dysfunction, seminal vesiculitis, testicular pain, urinary retention
CardiovascularCommon (1% to 10%): Hot flush, hypertension, hypotension, increased blood pressure, increased heart rate, palpitations, tachycardia
Frequency not reported: Angina pectoris, chest pain, increased orthostatic blood pressure, increased orthostatic heart rate response, increased systolic/diastolic blood pressure, labile hypertension, orthostatic hypotension, postural orthostatic tachycardia syndrome, sinus tachycardia, supraventricular and ventricular extra systoles
DermatologicCommon (1% to 10%): Hyperhidrosis, rash
Frequency not reported: Dry skin, erythematous rash, generalized rash, macular rash, maculopapular rash, pruritus, urticaria
MetabolicCommon (1% to 10%): Decreased appetite
Frequency not reported: Hyponatremia, increased blood cholesterol, thirst
PsychiatricFrequency not reported: Activation of mania/hypomania, aggression, agitation, anger, bruxism, discontinuation syndrome, panic attack, suicidal thought and behaviors in adolescents and young adults, tension
Nervous systemFrequency not reported: Extrapyramidal disorder, migraine, paresthesia, postural dizziness, seizure, serotonin syndrome, syncope
OcularFrequency not reported: Angle closure glaucoma, blurred vision, conjunctival hemorrhage, dry eye
HypersensitivityFrequency not reported: Hypersensitivity
HematologicFrequency not reported: Abnormal bleeding
HepaticFrequency not reported: Abnormal liver function test
RespiratoryFrequency not reported: Yawning
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Fetzima (www.drugs.com/fetzima.html).
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Fetzima is owned by Allergan.
FAQ Disclaimer: USA Rx LLC has a full endorsement of our prescription savings discount program. This product does not replace your insurance plan. You may check the price of both your insurance plan (copay) and our patient assistance program. That is an easy step for eligible patients to get the lowest price on your prescription medication. Our affiliates use the “powered by USA Rx” symbol in marketing materials. If you have a medical condition and need assistance with figuring out your best option is for a program of accurate discount pricing for prescription fills, please give us a call or drop us an email. If you need medical help, please seek proper medical care as soon as possible. Chat with your healthcare provider before beginning any prescription medication about all possible serious side effects and dosage requirements. A Fetzima prescription is an SNRI antidepressant medication intended to treat MDD with extended release capsules. Possible side effects of Fetzima may include irritability manic episodes, and an increased risk of suicidal thoughts or hypomania. Use Fetzima with caution and ask your healthcare provider if you have a history of hypomania, bipolar disorder, hyponatremia, manic episodes, have previously had bad reactions to antidepressant medications for MDD, or currently take Warfarin or a similar blood thinner. Fetzima is approved for use in adult patients, and patients below 18 years of age, particularly pediatric patients, are at added risk for serious side effects. Caregivers should discuss antidepressant medicines and treatment options with their healthcare provider. Fetzima should not be used for management of fibromyalgia, as this can lead to serious side effects. Suddenly stopping use of Fetzima can lead to serious discontinuation symptoms including irritability, electric shock sensation, and tinnitus, so speak with your healthcare provider first. Don't take Fetzima if you take an MAOI or SNRI, or recently stopped taking an MAOI or any other antidepressant medicines. Don't start or stop taking any other medications without first speaking to your healthcare provider, as this can have serious side effects. Always check with your healthcare provider about dosage values, and they may be able to provide you with a medication guide. USA Rx does not make any statement on the efficacy of the medication described here. All cardholders adhere to our privacy policy and we use recent information to create our accurate discount pricing estimates, which are subject to change. Prescription prices are subject to change.