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Fetzima Prescription
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Generic Name: levomilnacipran (LEE voe mil NA si pran)
Brand Names: Fetzima
Fetzima (levomilnacipran) is used to treat major depressive disorder. Includes Fetzima side effects, interactions and indications.
Generic Name: levomilnacipran (LEE voe mil NA si pran)
Brand Names: Fetzima
Fetzima (levomilnacipran) is used to treat major depressive disorder. Includes Fetzima side effects, interactions and indications.
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30 tablets of Fetzima 40 mg
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Fetzima Drug Information:

Fetzima (levomilnacipran) is a selective serotonin and norEpinephrine reuptake inhibitor antidepressant (SNRI). Levomilnacipran affects chemicals in the brain that may be unbalanced in people with depression. Fetzima is used to treat major depressive disorder. A similar medicine called milnacipran (savElla) is used to treat a chronic pain disorder called fibromyalgia. Fetzima should not be used to treat fibromyalgia. You should not use Fetzima if you have untreated or uncontrolled narrow-angle glaucoma. Learn more

Fetzima Side Effects

Note: This document contains side effect information about levomilnacipran. Some of the dosage forms listed on this page may not apply to the brand name Fetzima.

In Summary

Common side effects of Fetzima include: erectile dysfunction, nausea, and orthostatic hypotension. Other side effects include: constipation, ejaculatory disorder, epididymitis, increased heart rate, palpitations, premature ejaculation, sinus tachycardia, tachycardia, testicular pain, urinary hesitancy, vomiting, delayed ejaculation, ejaculation failure, and hyperhidrosis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to levomilnacipran: oral capsule extended release


Oral route (Capsule, Extended Release)

Antidepressants can increase the risk of suicidal thinking and behavior in children, adolescents, and young adults; however, this risk was not observed in patients older than 24 years and risk was reduced in patients 65 years or older. Closely monitor patients of all ages for clinical worsening and for emergence of suicidal thoughts and behaviors. Not approved for use in pediatric patients.

Along with its needed effects, levomilnacipran (the active ingredient contained in Fetzima) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking levomilnacipran:

More common

  • Difficult urination
  • fast, pounding, or irregular heartbeat or pulse

Less common

  • Anxiety
  • arm, back, or jaw pain
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • chest tightness or heaviness
  • cloudy urine
  • confusion
  • decrease in the frequency of urination
  • difficulty in passing urine (dribbling)
  • difficulty with speaking
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drooling
  • dry mouth
  • fainting
  • headache
  • irritability
  • loss of balance control
  • muscle trembling, jerking, or stiffness
  • nausea
  • painful urination
  • pounding in the ears
  • rapid or irregular heartbeat
  • restlessness
  • shaking
  • shortness of breath
  • shuffling walk
  • slow heartbeat
  • stiffness of the limbs
  • sweating
  • trouble sleeping
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back
  • unusual tiredness or weakness

Some side effects of levomilnacipran may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Difficulty having a bowel movement (stool)
  • increased sweating
  • loss in sexual ability, desire, drive, or performance
  • vomiting

Less common

  • Abdominal or stomach pain
  • bloated or full feeling
  • decreased appetite
  • dry eyes
  • dry skin
  • feeling of warmth
  • headache, severe and throbbing
  • hives or welts, itching, or rash
  • passing gas
  • red eye
  • red face, neck, arms, and occasionally, upper chest
  • sudden sweating
  • thirst
  • yawning

For Healthcare Professionals

Applies to levomilnacipran: oral capsule extended release


The most commonly reported side effects were nausea, erectile dysfunction, constipation, and hyperhidrosis.


Very common (10% or more): Nausea (up to 17%)

Common (1% to 10%): Constipation, vomiting

Frequency not reported: Abdominal pain, flatulence


Common (1% to 10%): Erectile dysfunction, ejaculation disorder, testicular pain, urinary hesitation

Frequency not reported: Delayed ejaculation, ejaculation failure, epididymitis, hematuria, organic erectile dysfunction, pollakiuria, premature ejaculation, proteinuria, psychogenic erectile dysfunction, seminal vesiculitis, testicular pain, urinary retention


Common (1% to 10%): Hot flush, hypertension, hypotension, increased blood pressure, increased heart rate, palpitations, tachycardia

Frequency not reported: Angina pectoris, chest pain, increased orthostatic blood pressure, increased orthostatic heart rate response, increased systolic/diastolic blood pressure, labile hypertension, orthostatic hypotension, postural orthostatic tachycardia syndrome, sinus tachycardia, supraventricular and ventricular extra systoles


Common (1% to 10%): Hyperhidrosis, rash

Frequency not reported: Dry skin, erythematous rash, generalized rash, macular rash, maculopapular rash, pruritus, urticaria


Common (1% to 10%): Decreased appetite

Frequency not reported: Hyponatremia, increased blood cholesterol, thirst


Frequency not reported: Activation of mania/hypomania, aggression, agitation, anger, bruxism, discontinuation syndrome, panic attack, suicidal thought and behaviors in adolescents and young adults, tension

Nervous system

Frequency not reported: Extrapyramidal disorder, migraine, paresthesia, postural dizziness, seizure, serotonin syndrome, syncope


Frequency not reported: Angle closure glaucoma, blurred vision, conjunctival hemorrhage, dry eye


Frequency not reported: Hypersensitivity


Frequency not reported: Abnormal bleeding


Frequency not reported: Abnormal liver function test


Frequency not reported: Yawning

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.

Source: Drugs.com Fetzima (www.drugs.com/fetzima.html).

What pharmacies accept this discount program?

Rite Aid, Wal-Mart, Walgreens, CVS, Duane Reade, Target, K-mart, and all national and regional chains accept the card.

What if you didn’t find your pharmacy names above?

Search our pharmacy network on our homepage and medication search results.

What if the pharmacist refuses to take the card?

If they are in the participating network, they legally have to accept and process the card. If they need help in processing the card, have them call the support phone number or email us directly.

What if the dosage, quantity, or drug name of the Fetzima coupon I downloaded is different than what I’m trying to fill right now?

Any coupon can be applied to any prescription medication at a participating pharmacy and receive a discount. Prescription prices are subject to change.

Do I have to show my coupon consecutive months when getting prescription fills at the pharmacy?

We recommend you show the coupon when getting prescription fills, but the pharmacy should keep your information in their system for future prescription fills.

Does this coupon work for brand name drug and the generic version?

Yes, both generic and brand prescription medication are covered by the coupon. Remember, any coupon can be applied to any prescription medication at a participating pharmacy and receive a discount with maximum savings.

Do you sell my personal information?

Absolutely not. We comply with US laws and government regulations regarding data and personal information.

What company owns Fetzima?

Fetzima is owned by Allergan.

Fetzima Prescription Savings Explained

FAQ Disclaimer: USA Rx LLC has a full endorsement of our prescription savings discount program. This product does not replace your insurance plan. You may check the price of both your insurance plan (copay) and our patient assistance program. That is an easy step for eligible patients to get the lowest price on your prescription medication. Our affiliates use the “powered by USA Rx” symbol in marketing materials. If you have a medical condition and need assistance with figuring out your best option is for a program of accurate discount pricing for prescription fills, please give us a call or drop us an email. If you need medical help, please seek proper medical care as soon as possible. Chat with your healthcare provider before beginning any prescription medication about all possible serious side effects and dosage requirements. A Fetzima prescription is an SNRI antidepressant medication intended to treat MDD with extended release capsules. Possible side effects of Fetzima may include irritability manic episodes, and an increased risk of suicidal thoughts or hypomania. Use Fetzima with caution and ask your healthcare provider if you have a history of hypomania, bipolar disorder, hyponatremia, manic episodes, have previously had bad reactions to antidepressant medications for MDD, or currently take Warfarin or a similar blood thinner. Fetzima is approved for use in adult patients, and patients below 18 years of age, particularly pediatric patients, are at added risk for serious side effects. Caregivers should discuss antidepressant medicines and treatment options with their healthcare provider. Fetzima should not be used for management of fibromyalgia, as this can lead to serious side effects. Suddenly stopping use of Fetzima can lead to serious discontinuation symptoms including irritability, electric shock sensation, and tinnitus, so speak with your healthcare provider first. Don't take Fetzima if you take an MAOI or SNRI, or recently stopped taking an MAOI or any other antidepressant medicines. Don't start or stop taking any other medications without first speaking to your healthcare provider, as this can have serious side effects. Always check with your healthcare provider about dosage values, and they may be able to provide you with a medication guide. USA Rx does not make any statement on the efficacy of the medication described here. All cardholders adhere to our privacy policy and we use recent information to create our accurate discount pricing estimates, which are subject to change. Prescription prices are subject to change.