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Note: This document contains side effect information about levomilnacipran. Some of the dosage forms listed on this page may not apply to the brand name Fetzima.In Summary
Common side effects of Fetzima include: erectile dysfunction, nausea, and orthostatic hypotension. Other side effects include: constipation, ejaculatory disorder, epididymitis, increased heart rate, palpitations, premature ejaculation, sinus tachycardia, tachycardia, testicular pain, urinary hesitancy, vomiting, delayed ejaculation, ejaculation failure, and hyperhidrosis. See below for a comprehensive list of adverse effects.For the Consumer
Applies to levomilnacipran: oral capsule extended release
Oral route (Capsule, Extended Release)
Antidepressants can increase the risk of suicidal thinking and behavior in children, adolescents, and young adults; however, this risk was not observed in patients older than 24 years and risk was reduced in patients 65 years or older. Closely monitor patients of all ages for clinical worsening and for emergence of suicidal thoughts and behaviors. Not approved for use in pediatric patients.
Along with its needed effects, levomilnacipran (the active ingredient contained in Fetzima) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking levomilnacipran:
Some side effects of levomilnacipran may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
For Healthcare Professionals
Applies to levomilnacipran: oral capsule extended releaseGeneral
The most commonly reported side effects were nausea, erectile dysfunction, constipation, and hyperhidrosis.Gastrointestinal
Very common (10% or more): Nausea (up to 17%)
Common (1% to 10%): Constipation, vomiting
Frequency not reported: Abdominal pain, flatulenceGenitourinary
Common (1% to 10%): Erectile dysfunction, ejaculation disorder, testicular pain, urinary hesitation
Frequency not reported: Delayed ejaculation, ejaculation failure, epididymitis, hematuria, organic erectile dysfunction, pollakiuria, premature ejaculation, proteinuria, psychogenic erectile dysfunction, seminal vesiculitis, testicular pain, urinary retentionCardiovascular
Common (1% to 10%): Hot flush, hypertension, hypotension, increased blood pressure, increased heart rate, palpitations, tachycardia
Frequency not reported: Angina pectoris, chest pain, increased orthostatic blood pressure, increased orthostatic heart rate response, increased systolic/diastolic blood pressure, labile hypertension, orthostatic hypotension, postural orthostatic tachycardia syndrome, sinus tachycardia, supraventricular and ventricular extra systolesDermatologic
Common (1% to 10%): Hyperhidrosis, rash
Frequency not reported: Dry skin, erythematous rash, generalized rash, macular rash, maculopapular rash, pruritus, urticariaMetabolic
Common (1% to 10%): Decreased appetite
Frequency not reported: Hyponatremia, increased blood cholesterol, thirstPsychiatric
Frequency not reported: Activation of mania/hypomania, aggression, agitation, anger, bruxism, discontinuation syndrome, panic attack, suicidal thought and behaviors in adolescents and young adults, tensionNervous system
Frequency not reported: Extrapyramidal disorder, migraine, paresthesia, postural dizziness, seizure, serotonin syndrome, syncopeOcular
Frequency not reported: Angle closure glaucoma, blurred vision, conjunctival hemorrhage, dry eyeHypersensitivity
Frequency not reported: HypersensitivityHematologic
Frequency not reported: Abnormal bleedingHepatic
Frequency not reported: Abnormal liver function testRespiratory
Frequency not reported: Yawning
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Fetzima is owned by Allergan.