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Fetzima (levomilnacipran) is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SNRI). Levomilnacipran affects chemicals in the brain that may be unbalanced in people with depression.
Fetzima is used to treat major depressive disorder.
A similar medicine called milnacipran (Savella) is used to treat a chronic pain disorder called fibromyalgia. Fetzima should not be used to treat fibromyalgia.
You should not use Fetzima if you have untreated or uncontrolled narrow-angle glaucoma.
Do not use Fetzima within 7 days before or 14 days after you have taken an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine.
Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Fetzima is not approved for use by anyone younger than 18 years old.
Do not use Fetzima within 7 days before or 14 days after you have taken an MAO inhibitor. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine.
You should not use Fetzima if you are allergic to levomilnacipran or milnacipran (Savella), or if you have untreated or uncontrolled narrow-angle glaucoma.
To make sure Fetzima is safe for you, tell your doctor if you have ever had:
heart disease, high blood pressure, heart rhythm disorder;
a bleeding or blood clotting disorder such as hemophilia;
bipolar disorder (manic depression);
narrow-angle glaucoma;
seizures or epilepsy;
kidney disease;
low levels of sodium in your blood;
bladder obstruction or other urination problems;
if you drink large amounts of alcohol; or
if you take a diuretic ("water pill") or use migraine headache medicine.
Some medicines can interact with levomilnacipran and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits while you are using Fetzima. Your family or other caregivers should also be alert to changes in your mood or symptoms.
It is not known whether Fetzima will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.
It is not known whether levomilnacipran passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Do not give this medicine to anyone younger than 18 years old without the advice of a doctor. Fetzima is not approved for use in children.
Take Fetzima exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
You may take Fetzima with or without food.
Do not crush, chew, break, or open a capsule. Swallow it whole.
Your blood pressure and heart rate will need to be checked often.
Do not stop using Fetzima suddenly, or you could have unpleasant withdrawal symptoms. Follow your doctor's instructions about tapering your dose.
Store at room temperature away from moisture and heat.
Usual Adult Dose for Depression:
Initial dose: 20 mg orally once a day for 2 days then increase to 40 mg orally once a day. Dose may be increased in increments of 40 mg at intervals of 2 or more days based on tolerability and efficacy.
Maintenance dose: 40 to 120 mg orally once a day
Maximum dose: 120 mg orally once a day
Approved indication: Major depressive disorder (MDD)
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Avoid drinking alcohol. It may raise your blood levels of Fetzima.
Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with Fetzima may cause you to bruise or bleed easily.
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Get emergency medical help if you have any signs of an allergic reaction to Fetzima: skin rash or hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
painful or difficult urination;
seizure (convulsions);
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
pounding heartbeats or fluttering in your chest; or
low levels of sodium in the body - headache, confusion, slurred speech, severe weakness, muscle cramps, loss of coordination, feeling unsteady, fainting, shallow breathing.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Older adults may be more sensitive to the side effects of this medication.
Common Fetzima side effects may include:
nausea, vomiting, constipation;
vision changes;
increased sweating;
fast heart rate; or
decreased sex drive, impotence, or difficulty having an orgasm.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Taking Fetzima with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking a sleeping pill, narcotic medication, muscle relaxer, or medicine for anxiety, depression, or seizures.
Tell your doctor about all your current medicines and any you start or stop using, especially:
any other antidepressant;
sibutramine;
tramadol;
St. John's wort;
tryptophan (sometimes called L-tryptophan);
a diuretic or "water pill";
a blood thinner (warfarin, Coumadin, Jantoven);
medicine to treat anxiety and mood disorders, thought disorders, or mental illness - buspirone, lithium, and many others; or
migraine headache medicine - sumatriptan, rizatriptan, zolmitriptan, and others.
This list is not complete. Other drugs may interact with levomilnacipran, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share Fetzima with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Fetzima (www.drugs.com/fetzima.html).
Note: This document contains side effect information about levomilnacipran. Some of the dosage forms listed on this page may not apply to the brand name Fetzima.
Common side effects of Fetzima include: erectile dysfunction, nausea, and orthostatic hypotension. Other side effects include: constipation, ejaculatory disorder, epididymitis, increased heart rate, palpitations, premature ejaculation, sinus tachycardia, tachycardia, testicular pain, urinary hesitancy, vomiting, delayed ejaculation, ejaculation failure, and hyperhidrosis. See below for a comprehensive list of adverse effects.
Applies to levomilnacipran: oral capsule extended release
Oral route (Capsule, Extended Release)
Antidepressants can increase the risk of suicidal thinking and behavior in children, adolescents, and young adults; however, this risk was not observed in patients older than 24 years and risk was reduced in patients 65 years or older. Closely monitor patients of all ages for clinical worsening and for emergence of suicidal thoughts and behaviors. Not approved for use in pediatric patients.
Along with its needed effects, levomilnacipran (the active ingredient contained in Fetzima) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking levomilnacipran:
More common
Less common
Some side effects of levomilnacipran may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Applies to levomilnacipran: oral capsule extended release
The most commonly reported side effects were nausea, erectile dysfunction, constipation, and hyperhidrosis.
Very common (10% or more): Nausea (up to 17%)
Common (1% to 10%): Constipation, vomiting
Frequency not reported: Abdominal pain, flatulence
Common (1% to 10%): Erectile dysfunction, ejaculation disorder, testicular pain, urinary hesitation
Frequency not reported: Delayed ejaculation, ejaculation failure, epididymitis, hematuria, organic erectile dysfunction, pollakiuria, premature ejaculation, proteinuria, psychogenic erectile dysfunction, seminal vesiculitis, testicular pain, urinary retention
Common (1% to 10%): Hot flush, hypertension, hypotension, increased blood pressure, increased heart rate, palpitations, tachycardia
Frequency not reported: Angina pectoris, chest pain, increased orthostatic blood pressure, increased orthostatic heart rate response, increased systolic/diastolic blood pressure, labile hypertension, orthostatic hypotension, postural orthostatic tachycardia syndrome, sinus tachycardia, supraventricular and ventricular extra systoles
Common (1% to 10%): Hyperhidrosis, rash
Frequency not reported: Dry skin, erythematous rash, generalized rash, macular rash, maculopapular rash, pruritus, urticaria
Common (1% to 10%): Decreased appetite
Frequency not reported: Hyponatremia, increased blood cholesterol, thirst
Frequency not reported: Activation of mania/hypomania, aggression, agitation, anger, bruxism, discontinuation syndrome, panic attack, suicidal thought and behaviors in adolescents and young adults, tension
Frequency not reported: Extrapyramidal disorder, migraine, paresthesia, postural dizziness, seizure, serotonin syndrome, syncope
Frequency not reported: Angle closure glaucoma, blurred vision, conjunctival hemorrhage, dry eye
Frequency not reported: Hypersensitivity
Frequency not reported: Abnormal bleeding
Frequency not reported: Abnormal liver function test
Frequency not reported: Yawning
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Fetzima (www.drugs.com/fetzima.html).
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