Note: This document contains side effect information about deferiprone. Some of the dosage forms listed on this page may not apply to the brand name Ferriprox.
More frequent side effects include: neutropenia and increased serum alanine aminotransferase. See below for a comprehensive list of adverse effects.
Applies to deferiprone: oral solution, oral tablet
Oral route (Tablet; Solution)
Deferiprone can cause agranulocytosis, often preceded by neutropenia, that can lead to serious infections and death. Measure the absolute neutrophil count (ANC) before starting deferiprone therapy and weekly on therapy. Interrupt deferiprone therapy if neutropenia or infection develops and monitor the ANC more frequently. Advise patients to immediately report any symptoms indicative of infection.
Along with its needed effects, deferiprone (the active ingredient contained in Ferriprox) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking deferiprone:
Incidence not known
Some side effects of deferiprone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Applies to deferiprone: oral liquid, oral tablet
The most common adverse events were chromaturia, nausea, vomiting, abdominal pain, alanine aminotransferase increased, arthralgia, and neutropenia.
Gastrointestinal effects are more frequent at the beginning of therapy, and in most patients resolve within a few weeks without the discontinuation of treatment.
Very common (10% or more): Nausea (12.6%), abdominal pain/discomfort (10.4%), vomiting
Common (1% to 10%): Diarrhea, dyspepsia, abdominal discomfort, abdominal pain, abdominal pain upper
Uncommon (0.1% to 1%): Abdominal distension, abdominal pain lower, aphthous stomatitis, constipation, epigastric discomfort, eructation, gastritis, reflux esophagitis, stomach discomfort, gastroenteritis, gastroenteritis viral
Postmarketing reports: Enterocolitis, rectal hemorrhage, gastric ulcer, pancreatitis, parotid gland enlargement, cecitis, dysphagia
Very common (10% or more): Chromaturia (14.6%)
Uncommon (0.1% to 1%): Pollakiuria, amenorrhea, menstruation irregular
Postmarketing reports: Glycosuria, hypospadias, congenital anomaly, non-acute porphyria, urinary tract infection, urine color abnormal, intra-uterine death, balanitis
Very common (10% or more): Arthralgia
Common (1% to 10%): Back pain, pain in extremity, arthropathy, joint swelling
Uncommon (0.1% to 1%): Epicondylitis, arthritis, bone pain, joint crepitation, joint effusion, joint range of motion decreased, joint stiffness, metatarsalgia, muscle spasms, muscular weakness, musculoskeletal chest pain, musculoskeletal pain, myalgia, polyarthritis, synovial cyst
Postmarketing reports: Myositis, chondropathy, trismus
Common (1% to 10%): Neutrophil count decreased, neutropenia, agranulocytosis, white blood cell count decreased
Uncommon (0.1% to 1%): Blood disorder, hypersplenism, leukopenia, thrombocytopenia, platelet count decreased, platelet count increased
Postmarketing reports: Thrombocytosis, pancytopenia, febrile neutropenia, thrombocythemia, granulocytopenia, hemoglobin decrease, neutropenic sepsis
Common (1% to 10%): Alanine aminotransferase increased, aspartate aminotransferase increased, increased liver enzymes
Uncommon (0.1% to 1%): Hepatic pain, hepatitis, hepatomegaly, jaundice, liver tenderness, cytomegalovirus hepatitis, blood bilirubin increased, hepatic enzyme increased
Postmarketing reports: Hepatic function abnormal, infectious hepatitis
Common (1% to 10%): Fatigue, peripheral edema
Uncommon (0.1% to 1%): Deafness, ear pain, tinnitus, vertigo, asthenia, chest pain, discomfort, fatigue, influenza like illness, malaise, pyrexia, thirst, diabetic foot infection, sepsis, Yersinia infection, transfusion reaction, blood creatinine increased, blood phosphorus increased, blood zinc decreased, gamma-glutamyl transferase increased
Frequency not reported: Progression of fibrosis
Postmarketing reports: Chills, multi-organ failure, pharyngitis, pneumonia, sepsis, blood creatinine phosphokinase increased, difficulty in walking, hyperpyrexia, anti-HBs antibody positive, blood arsenic increased
Common (1% to 10%): Increased appetite, weight increased, decreased appetite, anorexia
Uncommon (0.1% to 1%): Weight decreased, fluid retention
Postmarketing reports: Metabolic acidosis, dehydration, metabolic disorder
Uncommon (0.1% to 1%): Influenza, nasopharyngitis, upper respiratory tract infection, asthma, dry throat, oropharyngeal pain
Postmarketing reports: Acute respiratory distress syndrome, epistaxis, hemoptysis, pulmonary embolism, respiratory acidosis, dyspnea, lung disorder, oropharyngolaryngeal pain, pharyngeal erythema, tonsillitis, parapharyngeal abscess
Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Dizziness, hypogeusia, migraine, somnolence
Frequency not reported: Psychomotor slowdown, hand movements, axial hypotonia
Postmarketing reports: Cerebellar syndrome, cerebral hemorrhage, convulsion, gait disturbance, intracranial pressure increased, psychomotor skills impaired, pyramidal tract syndrome, dystonia, febrile convulsion, coordination abnormal, hypotonia, nystagmus, depressed level of consciousness, balance disorder, enteroviral encephalitis
Uncommon (0.1% to 1%): Hypersensitivity
Postmarketing reports: Anaphylactic shock
Uncommon (0.1% to 1%): Arrhythmia, Torsades de Pointes, electrocardiogram T wave inversion
Postmarketing reports: Atrial fibrillation, cardiac failure, hypotension, hypertension, cardiac disorder, congestive cardiac failure, sinus tachycardia
Uncommon (0.1% to 1%): Alopecia, hyperhidrosis, pruritus, rash, rash generalized, rash pruritic, skin hypopigmentation, urticaria, xeroderma
Frequency not reported: Henoch-Schönlein purpura, urticaria, periorbital edema with skin rash
Postmarketing reports: Cryptococcal cutaneous infection, rash pustular, subcutaneous abscess, hyperhidrosis, photosensitivity reaction, rash erythematous, rash maculopapular, face edema, furuncle, subcutaneous abscess
Postmarketing reports: Hemoglobinuria, renal failure, glycosuria, chromaturia
Postmarketing reports: Blood corticotrophin decreased, blood cortisol decreased
Frequency not reported: Lateral nystagmus
Postmarketing reports: Diplopia, papilledema, retinal toxicity, eye movement disorder, periorbital edema, retinal toxicity, visual impairment
Postmarketing reports: Hepatic neoplasm malignant
Postmarketing reports: Bruxism, depression, obsessive-compulsive disorder
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Ferriprox (www.drugs.com/ferriprox.html).
March 27, 2020
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