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Ezetimibe reduces the amount of cholesterol absorbed by the body.
Ezetimibe is used to treat high cholesterol.
Ezetimibe is sometimes given with other cholesterol-lowering medications.
Ezetimibe is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.
Some cholesterol medications should not be taken at the same time. If you take ezetimibe with another cholesterol medicine, follow your doctor's dosing instructions very carefully.
You should not use ezetimibe if you have moderate to severe liver disease. You should not use ezetimibe with a "statin" cholesterol medicine if you have active liver disease, or if you are pregnant or breast-feeding a baby.
Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
You should not use ezetimibe if you are allergic to it, or if you have:
moderate to severe liver disease.
You should not use ezetimibe with a "statin" cholesterol medicine (Zocor, Lipitor, Crestor, and others) if:
you have active liver disease;
you are pregnant; or
you are breast-feeding a baby.
To make sure this medicine is safe for you, tell your doctor if you have:
kidney disease; or
a thyroid disorder.
Before you start taking this medicine, tell your doctor if you already take a statin cholesterol medicine.
Some cholesterol medications can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).
You should not take ezetimibe with a statin medication if you are pregnant or breast-feeding.
It is not known whether ezetimibe alone will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Use effective birth control to prevent pregnancy while you are using ezetimibe with a statin medication.
It is not known whether ezetimibe alone passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. You should not breast-feed if you take this medicine with a statin medication.
Take ezetimibe exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Ezetimibe is usually taken once daily. Take the medicine at the same time each day.
You may take this medicine with or without food.
Ezetimibe may be taken at the same time with fenofibrate, or with a statin medication such as atorvastatin, lovastatin, simvastatin, pravastatin, or fluvastatin.
Some cholesterol medications should not be taken at the same time.
If you also take cholestyramine, colestipol, or colesevelam: You may take ezetimibe 2 hours before taking any of these medicines or wait at least 4 hours after taking any of these other medicines.
You should not take ezetimibe with gemfibrozil.
You may need frequent blood tests to check your liver function if you take ezetimibe with a statin medicine.
It may take up to 2 weeks before your cholesterol levels improve. Keep using your medication as directed. You will need frequent blood tests to measure your cholesterol levels.
Ezetimibe is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.
Store at room temperature away from moisture and heat.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Avoid eating foods that are high in fat or cholesterol. This medicine will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.
Get emergency medical help if you have signs of an allergic reaction to ezetimibe: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some cholesterol medications can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
Side effects may be more likely in older adults.
Common ezetimibe side effects may include:
muscle or joint pain;
stuffy nose, sinus pain, sore throat;
diarrhea; or
pain in an arm or leg.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Hyperlipidemia:
10 mg once a day with or without food.
Usual Adult Dose for Sitosterolemia:
10 mg once a day with or without food.
Tell your doctor about all your current medicines and any you start or stop using, especially:
cyclosporine; or
a blood thinner (warfarin, Coumadin, Jantoven).
This list is not complete. Other drugs may interact with ezetimibe, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Further informationRemember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use ezetimibe only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Ezetimibe (www.drugs.com/ezetimibe.html).
Applies to ezetimibe: oral tablet
Along with its needed effects, ezetimibe may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Frequency not determined
Some side effects of ezetimibe may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
For Healthcare Professionals
Applies to ezetimibe: oral tablet
GeneralThe most frequently reported side effects were upper respiratory tract infection, diarrhea, arthralgia, sinusitis, and pain in extremity.
GastrointestinalCommon (1% to 10%): Abdominal pain, diarrhea, flatulence
Uncommon (0.1% to 1%): Dyspepsia, gastroesophageal reflux disease, nausea
Postmarketing reports: Pancreatitis, constipation
ImmunologicPostmarketing reports: Anaphylaxis
MusculoskeletalCommon (1% to 10%): Arthralgia, pain in extremity
Uncommon (0.1% to 1%): Muscle spasms, neck pain
Postmarketing reports: Myalgia, myopathy, rhabdomyolysis
RespiratoryCommon (1% to 10%): Upper respiratory tract infection, sinusitis
Uncommon (0.1% to 1%): Cough
Postmarketing reports: Dyspnea
HypersensitivityPostmarketing reports: Hypersensitivity reaction
HepaticUncommon (0.1% to 1%): Gamma-glutamyltransferase increased, liver function test abnormal, AST/ALT increased
Postmarketing reports: Hepatitis, liver transaminases increased, cholelithiasis, cholecystitis
HematologicPostmarketing reports: Thrombocytopenia
Nervous systemUncommon (0.1% to 1%): Dizziness
Postmarketing reports: Paresthesia, headache
PsychiatricPostmarketing reports: Depression
CardiovascularUncommon (0.1% to 1%): Hot flush, hypertension
DermatologicPostmarketing reports: Angioedema, rash, urticaria, erythema multiforme
MetabolicUncommon (0.1% to 1%): Appetite decreased
OtherCommon (1% to 10%): Fatigue, influenza
Uncommon (0.1% to 1%): Chest pain, pain, creatine phosphokinase increased
Postmarketing reports: Asthenia
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Ezetimibe (www.drugs.com/ezetimibe.html).
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