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Extavia

Generic Name: interferon beta-1b (in ter FEAR on BAY ta 1b)
Brand Names: Betaseron, Extavia
Extavia is used to treat the relapsing forms of multiple sclerosis. Learn about side effects, interactions and indications.
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Drug Information:
Extavia (interferon beta-1b) is made from human proteins. Interferons help the body fight viral infections. Extavia is used to treat relapsing multiple sclerosis (MS). This medicine will not cure MS, it will only decrease the frequency of relapse symptoms. Extavia may also be used for purposes not listed in this medication guide. Extavia may be harmful to an unborn baby, or may cause a miscarriage. Do not use Extavia if you are pregnant. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Learn more

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Extavia Side Effects

Note: This document contains side effect information about interferon beta-1b. Some of the dosage forms listed on this page may not apply to the brand name Extavia.

In Summary

Common side effects of Extavia include: uterine hemorrhage, abdominal pain, antibody development, asthenia, chest pain, decreased white blood cell count, fever, flu-like symptoms, headache, hypertonia, increased serum alanine aminotransferase, injection site reaction, insomnia, leukopenia, myalgia, pain, anxiety, arthralgia, constipation, diarrhea, disorder of integument, dizziness, dyspepsia, lymphocytopenia, myasthenia, nausea, peripheral edema, skin rash, urinary urgency, abnormal absolute neutrophil count, chills, and inflammation at injection site. Other side effects include: alopecia, dyspnea, hypertension, lower limb cramp, lymphadenopathy, palpitations, tachycardia, tissue necrosis at injection site, impotence, nervousness, peripheral vascular disease, urinary frequency, vasodilation, weight gain, malaise, and diaphoresis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to interferon beta-1b: subcutaneous powder for solution

Along with its needed effects, interferon beta-1b (the active ingredient contained in Extavia) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking interferon beta-1b:

More common

  • Abdominal or stomach pain
  • break in the skin at the injection site, with blue-black discoloration, swelling, or drainage of fluid
  • flu-like symptoms including chills, fever, generalized feeling of discomfort or illness, increased sweating, and muscle pain
  • headache or migraine
  • hives, itching, or swelling at the injection site
  • irregular or pounding heartbeat
  • redness, pain, or feeling of heat at the injection site
  • stuffy nose

Less common

  • Bloody or cloudy urine
  • breast pain
  • changes in vision
  • cold hands and feet
  • difficult, burning, or painful urination
  • fast or racing heartbeat
  • frequent urge to urinate
  • pain
  • pelvic pain
  • swollen glands
  • troubled breathing
  • unusual weight gain

Rare

  • Abnormal growth in the breast
  • benign lumps in the breast
  • bleeding problems
  • bloating or swelling
  • changes in menstrual periods
  • confusion
  • convulsions (seizures)
  • cyst (abnormal growth filled with fluid or semisolid material)
  • decreased sexual ability in males
  • dry, puffy skin
  • feeling cold
  • hyperactivity
  • increased muscle tone
  • increased urge to urinate
  • loss of memory
  • mental depression with thoughts of suicide
  • problems with speaking
  • red, itching, or swollen eyes
  • swelling of the front part of the neck
  • unusual weight loss

Some side effects of interferon beta-1b may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Constipation
  • diarrhea
  • dizziness
  • loss of voice
  • menstrual pain or other changes
  • unusual tiredness or weakness

Less common

  • Anxiety
  • drowsiness
  • hair loss
  • vomiting

For Healthcare Professionals

Applies to interferon beta-1b: subcutaneous powder for injection

Cardiovascular

Common (1% to 10%): Tachycardia

Rare (Less than 0.1%): Cardiomyopathy, congestive heart failure, palpitations, arrhythmia, tachycardia, vasodilatation, chest pain, hypertension

Dermatologic

Very common (10% or more): Skin rashes (25%), increased sweating

Common (1% to 10%): Contusion, pruritus, erythematous rash, maculopapular rash, night sweats

Uncommon (0.1% to 1%): Alopecia, allergic dermatitis, erythema, urticaria

Rare (0.01% to 0.1%): Skin ulceration/necrosis at the site of injection, Quincke's edema (angioedema), erythema multiforme, Stevens-Johnson syndrome

Very rare (less than 0.01%): Calcified subcutaneous nodules, psoriasis, periungual and nail alterations

Frequency not reported: Rash vesicular

Endocrine

Uncommon (0.1% to 1%): Hypothyroidism, hyperthyroidism

Gastrointestinal

Very common (10% or more): Nausea (27%), diarrhea (17%), constipation (12%), vomiting (10%)

Common (1% to 10%): Abdominal pain

Frequency not reported: Dry mouth, dyspepsia, pancreatitis

General

Influenza-like symptoms (e.g., myalgia, fever, chills, sweating, asthenia, headache, nausea) are the most common adverse reactions.

Genitourinary

Very common (10% or more): Urinary tract infection (19%), cystitis (11%)

Frequency not reported: Metrorrhagia, menorrhagia, urinary incontinence, increase in the frequency of micturition

Hematologic

Very common (10% or more): Lymphopenia (14%), leukopenia (11%), neutropenia, thrombocytopenia, anemia

Common (1% to 10%): Neutrophil count decreased, hematocrit decreased, blood potassium increased, blood urea nitrogen increased

Uncommon (0.1% to 1%): Platelet count decreased

Rare (Less than 0.1%): Thrombotic microangiopathy including thrombotic thrombocytopenic purpura/hemolytic uremic syndrome,

Frequency not reported: Pancytopenia

Hepatic

Very common (10% or more): Alanine aminotransferase increased (26%), aspartate aminotransferase increased (16%)

Common (1% to 10%): Gamma-glutamyl-transferase increased

Uncommon (0.1% to 1%): Hepatitis (with or without icterus)

Rare (Less than 0.1%): Hepatic failure, autoimmune hepatitis

Frequency not reported: Elevation of hepatic transaminases (SGPT and SGOT), bilirubinemia, jaundice

Hypersensitivity

Rare (Less than 0.1%): Anaphylactic reactions

Frequency not reported: Other allergic reactions

Immunologic

Very common (10% or more): Influenza-like symptoms (49%)

Frequency not reported: Systemic lupus erythematosus, anaphylactic reaction, anaphylactic shock, hypersensitivity reactions (angioedema, dyspnea, urticaria, rash, pruritic rash)

Local

Very common (10% or more): Injection site erythema (62%), injection site pain (15%), injection site pruritus (13%), injection site bruising

Common (1% to 10%): Injection site edema, injection site warmth, injection site hematoma, injection site rash

Uncommon (0.1% to 1%): Injection site infections (which could be severe)

Rare (Less than 0.1%): Injection site cellulitis (which could be severe)

Frequency not reported: Injection site abscess, injection site reaction, injection site inflammation, injection site necrosis, injection site bleeding

Metabolic

Frequency not reported: Weight decreased, weight increased

Musculoskeletal

Very common (10% or more): Myalgia (19%), back pain (20%), pain in extremity (19%), arthralgia (16%), muscular weakness (12%), muscle spasms (10%)

Common (1% to 10%): Muscle spasticity, muscle cramp, neck pain, arthralgia, muscle stiffness, musculoskeletal stiffness

Rare (0.01% to 0.1%): Drug induced lupus erythematosus

Frequency not reported: Arthritis

Nervous system

Very common (10% or more): Headache (67%), dizziness (16%), paresthesia (12%)

Common (1% to 10%): Hypoesthesia

Uncommon (0.1% to 1%): Facial hypoesthesia

Frequency not reported: Neurological symptoms, syncope, hypertonia, seizures, migraine

Other

Very common (10% or more): Pyrexia (45%), asthenia (24%), pain (23%), fever (20%), chills (19%)

Common (1% to 10%): Fatigue, malaise, hyperthermia, vertigo

Frequency not reported: Tachyphylaxis, sudden hearing loss, tinnitus (ototoxic effects resolved 7 to 14 days after discontinuation of the drug)

Psychiatric

Common (1% to 10%): Depression/suicidal ideation, insomnia, somnolence

Uncommon (0.1% to 1%): Anxiety

Frequency not reported: Suicide attempt, suicide, psychosis, anxiety, confusion, emotional lability, anhedonia, psychotic thoughts, mood disturbances, hypersexuality, aggressive behavior, panic attacks

Renal

Rare (Less than 0.1%): Nephrotic syndrome, glomerulosclerosis

Respiratory

Very common (10% or more): Oropharyngeal pain (28%), nasopharyngitis (24%), upper respiratory tract infection (21%), cough (16%), sinusitis (14%)

Common (1% to 10%): Rhinorrhea, bronchitis

Rare (0.01% to 0.1%): Dyspnea

Frequency not reported: Pulmonary arterial hypertension

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Extavia (www.drugs.com/extavia.html).