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Exforge Prescription
Generic Name: amlodipine and valsartan (am LOE de peen val SAR tan)
Brand Names: Exforge
Exforge is used to treat high blood pressure (hypertension). Learn about side effects, interactions and indications.

Average Savings for amlodipine besylate/valsa (generic): 58.81%
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Exforge Drug Information:

Exforge contains a combination of amlodipine and Valsartan. Amlodipine is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels. Valsartan is an angiotensin II receptor antagonist. Valsartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Exforge is used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack. Exforge is usually given after other blood pressure medicines have been tried without success. Learn more

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Exforge Side Effects

Note: This document contains side effect information about amlodipine / valsartan. Some of the dosage forms listed on this page may not apply to the brand name Exforge.

For the Consumer

Applies to amlodipine / valsartan: oral tablet


Oral route (Tablet)

If pregnancy is confirmed, discontinue amlodipine valsartan immediately. Injury and death to the developing fetus may result from drugs that act directly on the renin-angiotensin system

Along with its needed effects, amlodipine / valsartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amlodipine / valsartan:

More common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • rapid weight gain
  • tingling of the hands or feet
  • unusual weight gain or loss

Less common

  • Body aches or pain
  • chills
  • cough
  • difficulty with breathing
  • dizziness
  • ear congestion
  • fever
  • headache
  • loss of voice
  • muscle aches
  • sneezing
  • sore throat
  • stuffy or runny nose
  • unusual tiredness or weakness


  • Ankle, knee, or great toe joint pain
  • bloody or cloudy urine
  • blurred or loss of vision
  • burning feeling in the chest or stomach
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • cold sweats
  • confusion
  • congestion
  • cough producing mucus
  • diarrhea
  • difficult, burning, or painful urination
  • disturbed color perception
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
  • dry mouth
  • fast, irregular, pounding, or racing heartbeat or pulse
  • flushed, dry skin
  • heart murmur
  • hives
  • hoarseness
  • indigestion
  • itching
  • joint pain, stiffness, or swelling
  • loss of appetite
  • nausea
  • pain in the lower back, bottom, or hips
  • pain in the upper leg
  • pain or tenderness around the eyes and cheekbones
  • rash
  • redness of the skin
  • stomach cramps, tenderness, or pain
  • sweating
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness of the chest
  • trouble with swallowing
  • troubled breathing
  • vomiting
  • watery or bloody diarrhea
  • weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking amlodipine / valsartan:

Symptoms of overdose

  • Chest discomfort
  • cold, clammy skin
  • fast, weak pulse
  • flushing
  • lightheadedness or fainting
  • slow heartbeat

Some side effects of amlodipine / valsartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


  • Acid or sour stomach
  • back pain
  • belching
  • bone pain
  • continuing ringing or buzzing or other unexplained noise in the ears
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • fear or nervousness
  • feeling sad or empty
  • full or bloated feeling
  • hearing loss
  • heartburn
  • inability to have or keep an erection
  • increased sensitivity to sunlight
  • irritability
  • itching, pain, redness, or swelling of the eye or eyelid
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance
  • loss of interest or pleasure
  • muscle aching or cramping
  • pain in the arms or legs
  • passing gas
  • pressure in the stomach
  • redness in the joints
  • redness of the skin
  • sensation of spinning
  • skin rash, encrusted, scaly, and oozing
  • sleepiness or unusual drowsiness
  • swelling of the abdominal or stomach area
  • tiredness
  • toothache
  • trouble concentrating
  • unable to sleep
  • unusually warm skin
  • watering of the eyes

For Healthcare Professionals

Applies to amlodipine / valsartan: oral tablet


The most common adverse reactions were BUN increased greater than 50%, peripheral edema, nasopharyngitis, upper respiratory tract infection, and dizziness.


Very common (10% or more): BUN increased greater than 50% (up to 10.9%)

Common (1% to 10%): Hypokalemia, serum potassium increased greater than 20%

Uncommon (0.1% to 1%): Anorexia, hypercalcemia, hyperlipidemia, hyperuricemia, hyponatremia, gout, non-insulin-dependent diabetes mellitus, hypercholesterolemia


Uncommon (0.1% to 1%): Weight increased, weight decreased

Very rare (less than 0.01%): Hyperglycemia

Common (1% to 10%): BUN increased

Frequency not reported: Serum potassium increased


Common (1% to 10%): Asthenia, fatigue, facial edema, edema, peripheral edema, pitting edema

Uncommon (0.1% to 1%): Ear pain, chest pain, pyrexia


Very common (10% or more): Peripheral edema (up to 10.3%)

Common (1% to 10%): Fatigue, edema, ankle swelling

Uncommon (0.1% to 1%): Gynecomastia, asthenia, discomfort, malaise, non-cardiac chest pain, pain


Common (1% to 10%): Peripheral edema

Uncommon (0.1% to 1%): Fatigue


Common (1% to 10%): Flushing, hot flush, orthostatic blood pressure decrease

Uncommon (0.1% to 1%): Palpitation, tachycardia, orthostatic hypotension

Rare (less than 0.1%): Hypotension


Common (1% to 10%): Palpitation, flushing

Uncommon (0.1% to 1%): Hypotension

Very rare (less than 0.01%): Arrhythmia, myocardial infarction, vasculitis


Frequency not reported: Vasculitis


Common (1% to 10%): Nasopharyngitis, upper respiratory tract infection

Uncommon (0.1% to 1%): Cough, pharyngolaryngeal pain, sinusitis, bronchitis, pharyngitis, pharyngotonsillitis, bronchitis acute, tonsillitis, sinus congestion, dyspnea, epistaxis, productive cough, dysphonia, nasal congestion


Uncommon (0.1% to 1%): Dyspnea, rhinitis

Very rare (less than 0.01%): Cough


Uncommon (0.1% to 1%): Cough

Nervous system

Common (1% to 10%): Headache, dizziness

Uncommon (0.1% to 1%): Coordination abnormal, dizziness postural, paresthesia, somnolence, vertigo, sciatica, cervicobrachial syndrome, carpal tunnel syndrome, hypoesthesia, sinus headache

Rare (less than 0.1%): Tinnitus, syncope


Common (1% to 10%): Dizziness, headache, somnolence

Uncommon (0.1% to 1%): Dysgeusia, paresthesia, syncope, tremor, hypoesthesia, tinnitus

Very rare (less than 0.01%): Hypertonia, peripheral neuropathy, neuropathy

Frequency not reported: Extrapyramidal syndrome


Uncommon (0.1% to 1%): Vertigo


Common (1% to 10%): Creatine kinase increased greater than 300%

Uncommon (0.1% to 1%): Arthralgia, back pain, joint swelling, epicondylitis, joint sprain, limb injury, muscle spasm, pain in extremity, myalgia, osteoarthritis, musculoskeletal chest pain

Rare (less than 0.1%): Sensation of heaviness


Uncommon (0.1% to 1%): Arthralgia, back pain, muscle spasm, myalgia


Frequency not reported: Myalgia

Postmarketing reports: Rhabdomyolysis


Common (1% to 10%): Influenza

Uncommon (0.1% to 1%): Seasonal allergy

Rare (less than 0.1%): Hypersensitivity


Very rare (less than 0.01%): Hypersensitivity


Frequency not reported: Hypersensitivity


Common (1% to 10%): Creatinine increased greater than 50%

Uncommon (0.1% to 1%): Nephrolithiasis


Frequency not reported: Serum creatinine increased, renal failure and impairment


Common (1% to 10%): ALT increased greater than 150%


Very rare (less than 0.01%): Liver function test abnormal, serum bilirubin increased, hepatitis, intrahepatic cholestasis, jaundice


Frequency not reported: Liver function test abnormal, serum bilirubin increased


Uncommon (0.1% to 1%): Abdominal discomfort, abdominal distention, abdominal pain, upper abdominal pain, constipation, diarrhea, dry mouth, nausea, dyspepsia, gastritis, vomiting, colitis, gastroenteritis


Common (1% to 10%): Abdominal discomfort, upper abdominal pain, nausea

Uncommon (0.1% to 1%): Change of bowel habit, diarrhea, dry mouth, dyspepsia, vomiting

Very rare (less than 0.01%): Gastritis, gingival hyperplasia, pancreatitis


Uncommon (0.1% to 1%): Abdominal discomfort, upper abdominal pain


Uncommon (0.1% to 1%): Erythema, rash, pruritus, hyperhidrosis, eczema

Rare (less than 0.1%): Exanthema


Uncommon (0.1% to 1%): Alopecia, exanthema, hyperhidrosis, photosensitivity reaction, pruritus, purpura, rash, skin discoloration

Very rare (less than 0.01%): Angioedema, erythema multiforme, urticaria, exfoliative dermatitis, Stevens-Johnson syndrome, Quincke edema


Frequency not reported: Angioedema, dermatitis bullous, pruritus, rash


Uncommon (0.1% to 1%): Hematuria, pollakiuria, erectile dysfunction

Rare (less than 0.1%): Polyuria


Uncommon (0.1% to 1%): Micturition disorder, nocturia, pollakiuria, impotence


Uncommon (0.1% to 1%): Insomnia, anxiety, depression


Uncommon (0.1% to 1%): Depression, insomnia/sleep disorders, mood swings

Rare (less than 0.1%): Confusion


Uncommon (0.1% to 1%): Visual impairment

Rare (less than 0.1%): Visual disturbance


Uncommon (0.1% to 1%): Visual disturbance, visual impairment


Uncommon (0.1% to 1%): Lymphadenopathy


Very rare (less than 0.01%): Leukopenia, thrombocytopenia


Frequency not reported: Hemoglobin decreased, hematocrit decreased, neutropenia, thrombocytopenia

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Exforge (www.drugs.com/exforge.html).