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Evista

Generic Name: raloxifene (ra LOX i feen)
Brand Names: Evista
Evista is used to treat and prevent osteoporosis in postmenopausal women. Learn about side effects, interactions and indications.
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Drug Information:
Evista (rAloxifene) affects the cycle of bone formation and breakdown in the body, and reduces loss of bone tissue. Evista is used to treat or prevent osteoporosis in postmenopausal women. Evista is also used to reduce the risk of invasive breast cancer in postmenopausal women who have osteoporosis or who are otherwise at risk of invasive breast cancer. Evista is not a cancer medication and will not treat breast cancer. Taking Evista may increase your risk of a blood clot in your leg, your lung, or your eye. You should not take this medicine if you have ever had a blood clot. Learn more

Evista Side Effects

Evista Side Effects

Note: This document contains side effect information about raloxifene. Some of the dosage forms listed on this page may not apply to the brand name Evista.

In Summary

Common side effects of Evista include: infection, flu-like symptoms, hot flash, and sinusitis. Other side effects include: lower limb cramp. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to raloxifene: oral tablet

Warning

Oral route (Tablet)

Increased risk of deep vein thrombosis and pulmonary embolism have been reported. Women with active or past history of venous thromboembolism should not take raloxifene hydrochloride. Increased risk of death due to stroke occurred in a trial in postmenopausal women with documented coronary heart disease or at increased risk for major coronary events. Consider risk-benefit balance in women at risk for stroke.

Along with its needed effects, raloxifene (the active ingredient contained in Evista) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking raloxifene and get emergency help immediately if any of the following effects occur:

Rare

  • Coughing blood
  • headache or migraine headache
  • loss of or change in speech, coordination, or vision
  • pain or numbness in chest, arm, or leg
  • shortness of breath (unexplained)

Check with your doctor as soon as possible if any of the following side effects occur while taking raloxifene:

More common

  • Bloody or cloudy urine
  • chest pain
  • difficult, burning, or painful urination
  • fever
  • frequent urge to urinate
  • infection, including body aches or pain, congestion in throat, cough, dryness or soreness of throat, runny nose, and loss of voice
  • leg cramping
  • skin rash
  • swelling of hands, ankles, or feet
  • vaginal itching

Less common

  • Abdominal pain (severe)
  • aching body pains
  • congestion in lungs
  • decreased vision or other changes in vision
  • diarrhea
  • difficulty in breathing
  • hoarseness
  • loss of appetite
  • nausea
  • trouble in swallowing
  • weakness

Some side effects of raloxifene may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Hot flashes, including sudden sweating and feelings of warmth (especially common during the first 6 months of treatment)
  • increased white vaginal discharge
  • joint or muscle pain
  • mental depression
  • problems of stomach or intestines, including passing of gas, upset stomach, or vomiting
  • swollen joints
  • trouble in sleeping
  • weight gain (unexplained)

For Healthcare Professionals

Applies to raloxifene: oral tablet

Cardiovascular

Very common (10% or more): Hot flashes/hot flushes/vasodilation (28.7%), increased blood pressure

Common (1% to 10%): Varicose vein, venous thromboembolism (VTE)

Postmarketing reports: Death related to VTE

Other

Very common (10% or more): Flu syndrome (16.2%), infection (15.1%), peripheral edema (14.1%)

Common (1% to 10%): Chest pain, fever

Musculoskeletal

Very common (10% or more): Arthralgia (15.5%), muscle spasms/leg cramps (12.1%)

Common (1% to 10%): Myalgia, arthritis, tendon disorder

Respiratory

Very common (10% or more): Sinusitis (10.3%), rhinitis (10.2%)

Common (1% to 10%): Bronchitis, pharyngitis, increased cough, pneumonia, laryngitis

Dermatologic

Common (1% to 10%): Rash, sweating

Endocrine

Common (1% to 10%): Breast pain/tenderness/enlargement

Gastrointestinal

Common (1% to 10%): Nausea, diarrhea, dyspepsia, vomiting, flatulence, gastrointestinal disorder, gastroenteritis, abdominal pain

Genitourinary

Common (1% to 10%): Vaginitis, urinary tract infection, cystitis, leukorrhea, uterine disorder, vaginal bleeding, endometrial disorder, vaginal hemorrhage, urinary tract disorder

Hepatic

Common (1% to 10%): Cholelithiasis, cholecystectomy

Frequency not reported: Slightly decreased platelet counts, moderate increases in AST and/or ALT

Metabolic

Common (1% to 10%): Weight gain

Nervous system

Common (1% to 10%): Headache/migraine, syncope, vertigo, neuralgia, hypesthesia, stroke, death related to stroke

Ocular

Common (1% to 10%): Conjunctivitis

Postmarketing reports: Retinal vein occlusion

Psychiatric

Common (1% to 10%): Depression, insomnia

Hematologic

Uncommon (0.1% to 1%): Thrombocytopenia

Oncologic

Uncommon (0.1% to 1%): Benign endometrial polyps

Frequency not reported: Endometrial cancer, ovarian cancer, endometrial atrophy

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Evista (www.drugs.com/evista.html).