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Ethosuximide Prescription
Generic Name: ethosuximide (ETH oh SUX i mide)
Brand Name: Zarontin
Physician reviewed ethosuximide patient information - includes ethosuximide description, dosage and directions.

Average Savings for ethosuximide (generic): 44.88%
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Ethosuximide Drug Information:

Ethosuximide is an anti-epileptic medication, also called an anticonvulsant. Ethosuximide is used alone or in combination with other medications to treat absence seizures (also called "petit mal" seizures) in adults and children. Ethosuximide may also be used for purposes not listed in this medication guide. Do not stop using ethosuximide suddenly. Stopping suddenly may cause increased seizures. You should not use ethosuximide if you are allergic to ethosuximide or to other seizure medications. Learn more

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Ethosuximide Side Effects

For the Consumer

Applies to ethosuximide: oral capsule liquid filled, oral syrup

Along with its needed effects, ethosuximide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ethosuximide:


  • Changes in behavior
  • discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • mood or mental changes
  • thoughts of killing oneself
  • tiredness
  • trouble with concentrating
  • trouble with sleeping

Incidence not known

  • Attack, assault, or force
  • blistering, peeling, or loosening of the skin
  • blood in the urine
  • bloody, black, or tarry stools
  • chest pain
  • cough or hoarseness
  • diarrhea
  • enlarged gums
  • false or unusual sense of well-being
  • fever and chills
  • fever with or without chills
  • general feeling of discomfort or illness
  • general feeling of tiredness or weakness
  • hair loss
  • headaches
  • high fever
  • hives, itching, and skin rash
  • joint or muscle pain
  • lower back or side pain
  • nervousness
  • not able to concentrate
  • painful or difficult urination
  • pale skin
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • restlessness
  • shakiness and unsteady walk
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling around the eyes
  • swelling of the tongue
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • trouble sitting still
  • trouble with breathing
  • unexplained bleeding or bruising
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vaginal bleeding
  • vision changes
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking ethosuximide:

Symptoms of overdose

  • Change in consciousness
  • irregular, fast or slow, or shallow breathing
  • loss of consciousness
  • pale or blue lips, fingernails, or skin

Some side effects of ethosuximide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


  • Increased in sexual ability, desire, drive, or performance
  • increased interest in sexual intercourse

Incidence not known

  • Cramps
  • dizziness
  • drowsiness
  • heartburn
  • hiccups
  • increased hair growth, especially on the face
  • loss of appetite
  • nausea or vomiting
  • nearsightedness
  • pain or discomfort in the chest, upper stomach, or throat
  • redness of the skin
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  • weight loss

For Healthcare Professionals

Applies to ethosuximide: oral capsule, oral syrup


The more commonly reported adverse reactions have included gastrointestinal symptoms such as anorexia, vague gastric upset, nausea and vomiting, and abdominal pain.


Frequency not reported: Anorexia, vague gastric upset, nausea, vomiting, cramps, epigastric and abdominal pain, weight loss, gum hypertrophy, diarrhea, swollen tongue, hiccups


Frequency not reported: Urticaria, Stevens-Johnson syndrome (SJS), pruritic erythematous rashes, hirsutism, Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), systemic lupus erythematosus


Frequency not reported: Leukopenia, agranulocytosis, pancytopenia (with or without bone marrow suppression), eosinophilia

Nervous system

Frequency not reported: Drowsiness, headache, dizziness, lethargy, fatigue, ataxia


Rare (less than 0.1%): Paranoid psychosis, increased libido, increased state of depression with overt suicidal intentions

Frequency not reported: Disturbances, night terrors, inability to concentrate, aggressiveness, euphoria, irritability, hyperactivity


Frequency not reported: Myopia


Frequency not reported: Vaginal bleeding, microscopic hematuria


Frequency not reported: Allergic reaction

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Ethosuximide (www.drugs.com/mtm/ethosuximide.html).