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Eszopiclone

Generic Name: eszopiclone (e ZOP i klone)
Brand Name: Lunesta
Physician reviewed eszopiclone patient information - includes eszopiclone description, dosage and directions.

Average Savings for eszopiclone (generic): 75.23%
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Eszopiclone Side Effects

Eszopiclone Side Effects

In Summary

Commonly reported side effects of eszopiclone include: infection, drowsiness, and unpleasant taste. Other side effects include: nausea, dizziness, and xerostomia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to eszopiclone: oral tablet

Along with its needed effects, eszopiclone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking eszopiclone:

More common

  • Cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • sleepiness or unusual drowsiness

Less common

  • Bladder pain
  • bloody or cloudy urine
  • cold flu-like symptoms
  • confusion
  • difficult, burning, or painful urination
  • discouragement
  • fear or nervousness
  • feeling sad or empty
  • frequent urge to urinate
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • nerve pain
  • seeing, hearing, or feeling things that are not there
  • tiredness
  • trouble concentrating
  • trouble sleeping

Some side effects of eszopiclone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acid or sour stomach
  • bad, unusual, or unpleasant (after) taste
  • belching
  • change in taste
  • dizziness
  • dry mouth
  • headache
  • heartburn
  • indigestion
  • nausea
  • pain
  • stomach discomfort, upset, or pain

Less common

  • Abnormal dreams
  • accidental injury
  • decreased interest in sexual intercourse
  • diarrhea
  • inability to have or keep an erection
  • pain, cramps, or heavy bleeding (females)
  • rash
  • swelling of the breasts or breast soreness (in both males and females)
  • vomiting

Incidence not known

  • Loss of memory
  • problems with memory

For Healthcare Professionals

Applies to eszopiclone: oral tablet

General

The most commonly reported side effects included unpleasant taste, headache, somnolence, and infection.

Nervous system

A dose-response relationship appears to exist for dizziness and unpleasant taste.

Headache was reported in 21% of non-elderly patients given 2 mg orally for 6 weeks, and in 17% of non-elderly adults given 3 mg orally for 6 weeks.

In patients 65 to 86 years of age, headache occurred in up to 15% of patients given 1 mg, and unpleasant taste occurred in up to 12% of patients given 2 mg orally for 2 weeks.

Dizziness and neuralgia commonly occurred in patients aged 65 years of age or older. Somnolence has also been reported in this patient population.

Very common (10% or more): Unpleasant taste (up to 34%), headache (up to 21%)

Common (1% to 10%): Dizziness, migraine, neuralgia, somnolence

Uncommon (0.1% to 1%): Ataxia, decreased reflexes, difficulty concentrating, hypertonia, hypesthesia, incoordination, memory impairment, nystagmus, paresthesia, vertigo, vestibular disorder

Rare (less than 0.1%): Abnormal gait, hyperesthesia, hypokinesia, neuritis, neuropathy, stupor, tremor

Postmarketing reports: Dysosmia

Psychiatric

A dose-response relationship appears to exist for confusion, decreased libido, and hallucinations.

Abnormal dreams and nervousness commonly occurred in patients aged 65 years of age or older.

Common (1% to 10%): Abnormal dreams, anxiety, confusion, decreased libido, depression, hallucinations, nervousness

Uncommon (0.1% to 1%): Abnormal thinking, agitation, apathy, emotional lability, hostility, insomnia, neurosis,

Rare (less than 0.1%): Euphoria

Gastrointestinal

A dose-response relationship appears to exist for dry mouth.

Diarrhea, dry mouth, and dyspepsia commonly occurred in patients aged 65 years of age or older. Abdominal pain and nausea have also been reported in this patient population.

Common (1% to 10%): Diarrhea, dry mouth, dyspepsia, nausea, vomiting

Uncommon (0.1% to 1%): Halitosis, melena, mouth ulceration, ulcerative stomatitis

Rare (less than 0.1%): Colitis, dysphagia, gastritis, rectal hemorrhage, stomach ulcer, stomatitis, tongue edema

Frequency not reported: Abdominal pain

Genitourinary

Urinary tract infections commonly occurred in patients aged 65 years of age or older.

Common (1% to 10%): Dysmenorrhea, urinary tract infection

Uncommon (0.1% to 1%): Amenorrhea, breast engorgement, breast enlargement, breast pain, cystitis, dysuria, female lactation, hematuria, mastitis, menorrhagia, metrorrhagia, urinary frequency, urinary incontinence, uterine hemorrhage, vaginal hemorrhage, vaginitis

Rare (less than 0.1%): Urethritis

Dermatologic

Common (1% to 10%): Pruritus, rash

Uncommon (0.1% to 1%): Acne, alopecia, cellulitis, contact dermatitis, dry skin, eczema, photosensitivity, skin discoloration, sweating, urticaria

Rare (less than 0.1%): Erythema multiforme, furunculosis, hirsutism, maculopapular rash, vesiculobullous rash

A dose-response relationship appears to exist for rash.

Pruritus commonly occurred in patients aged 65 years of age or older. Abdominal pain has also been reported in this patient population.

Other

A dose-response relationship appears to exist for accidental injury and pain.

Accidental injury and pain commonly occurred in patients aged 65 years of age or older. Asthenia and pain have also been reported in this patient population.

Common (1% to 10%): Accidental injury, pain

Uncommon (0.1% to 1%): Ear pain, face edema, fever, hernia, malaise, otitis externa, otitis media, tinnitus

Rare (less than 0.1%): Hyperacusis

Frequency not reported: Asthenia

Cardiovascular

Common (1% to 10%): Chest pain, peripheral edema

Uncommon (0.1% to 1%): Heat stroke, hypertension

Rare (less than 0.1%): Thrombophlebitis

Immunologic

A dose-response relationship appears to exist for infection.

Common (1% to 10%): Infection, viral infection

Rare (less than 0.1%): Herpes zoster

Frequency not reported: Flu syndrome

Hypersensitivity

Uncommon (0.1% to 1%): Allergic reaction

Endocrine

Common (1% to 10%): Gynecomastia

Musculoskeletal

Uncommon (0.1% to 1%): Arthritis, bursitis, joint disorder, joint pain, joint swelling, joint stiffness, leg cramps, myasthenia, neck rigidity, twitching

Rare (less than 0.1%): Arthrosis, myopathy

Frequency not reported: Back pain, myalgia

Metabolic

Uncommon (0.1% to 1%): Anorexia, hypercholesterolemia, increased appetite, thirst, weight gain, weight loss

Rare (less than 0.1%): Dehydration, gout, hyperlipemia, hypokalemia

Respiratory

Uncommon (0.1% to 1%): Asthma, bronchitis, dyspnea, epistaxis, hiccup, laryngitis

Frequency not reported: Pharyngitis, rhinitis

Ocular

Uncommon (0.1% to 1%): Conjunctivitis, dry eyes

Rare (less than 0.1%): Iritis, mydriasis, photophobia, ptosis

Renal

Uncommon (0.1% to 1%): Kidney calculus, kidney pain

Rare (less than 0.1%): Oliguria, pyelonephritis

Hematologic

Uncommon (0.1% to 1%): Anemia, lymphadenopathy

Hepatic

Uncommon (0.1% to 1%): Cholelithiasis

Rare (less than 0.1%): Hepatitis, hepatomegaly, liver damage

Oncologic

Uncommon (0.1% to 1%): Breast neoplasm

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Eszopiclone (www.drugs.com/eszopiclone.html).

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