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Commonly reported side effects of eszopiclone include: infection, drowsiness, and unpleasant taste. Other side effects include: nausea, dizziness, and xerostomia. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to eszopiclone: oral tablet
Along with its needed effects, eszopiclone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking eszopiclone:
More common
Less common
Some side effects of eszopiclone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Incidence not known
For Healthcare Professionals
Applies to eszopiclone: oral tablet
GeneralThe most commonly reported side effects included unpleasant taste, headache, somnolence, and infection.
Nervous systemA dose-response relationship appears to exist for dizziness and unpleasant taste.
Headache was reported in 21% of non-elderly patients given 2 mg orally for 6 weeks, and in 17% of non-elderly adults given 3 mg orally for 6 weeks.
In patients 65 to 86 years of age, headache occurred in up to 15% of patients given 1 mg, and unpleasant taste occurred in up to 12% of patients given 2 mg orally for 2 weeks.
Dizziness and neuralgia commonly occurred in patients aged 65 years of age or older. Somnolence has also been reported in this patient population.
Very common (10% or more): Unpleasant taste (up to 34%), headache (up to 21%)
Common (1% to 10%): Dizziness, migraine, neuralgia, somnolence
Uncommon (0.1% to 1%): Ataxia, decreased reflexes, difficulty concentrating, hypertonia, hypesthesia, incoordination, memory impairment, nystagmus, paresthesia, vertigo, vestibular disorder
Rare (less than 0.1%): Abnormal gait, hyperesthesia, hypokinesia, neuritis, neuropathy, stupor, tremor
Postmarketing reports: Dysosmia
PsychiatricA dose-response relationship appears to exist for confusion, decreased libido, and hallucinations.
Abnormal dreams and nervousness commonly occurred in patients aged 65 years of age or older.
Common (1% to 10%): Abnormal dreams, anxiety, confusion, decreased libido, depression, hallucinations, nervousness
Uncommon (0.1% to 1%): Abnormal thinking, agitation, apathy, emotional lability, hostility, insomnia, neurosis,
Rare (less than 0.1%): Euphoria
GastrointestinalA dose-response relationship appears to exist for dry mouth.
Diarrhea, dry mouth, and dyspepsia commonly occurred in patients aged 65 years of age or older. Abdominal pain and nausea have also been reported in this patient population.
Common (1% to 10%): Diarrhea, dry mouth, dyspepsia, nausea, vomiting
Uncommon (0.1% to 1%): Halitosis, melena, mouth ulceration, ulcerative stomatitis
Rare (less than 0.1%): Colitis, dysphagia, gastritis, rectal hemorrhage, stomach ulcer, stomatitis, tongue edema
Frequency not reported: Abdominal pain
GenitourinaryUrinary tract infections commonly occurred in patients aged 65 years of age or older.
Common (1% to 10%): Dysmenorrhea, urinary tract infection
Uncommon (0.1% to 1%): Amenorrhea, breast engorgement, breast enlargement, breast pain, cystitis, dysuria, female lactation, hematuria, mastitis, menorrhagia, metrorrhagia, urinary frequency, urinary incontinence, uterine hemorrhage, vaginal hemorrhage, vaginitis
Rare (less than 0.1%): Urethritis
DermatologicCommon (1% to 10%): Pruritus, rash
Uncommon (0.1% to 1%): Acne, alopecia, cellulitis, contact dermatitis, dry skin, eczema, photosensitivity, skin discoloration, sweating, urticaria
Rare (less than 0.1%): Erythema multiforme, furunculosis, hirsutism, maculopapular rash, vesiculobullous rash
A dose-response relationship appears to exist for rash.
Pruritus commonly occurred in patients aged 65 years of age or older. Abdominal pain has also been reported in this patient population.
OtherA dose-response relationship appears to exist for accidental injury and pain.
Accidental injury and pain commonly occurred in patients aged 65 years of age or older. Asthenia and pain have also been reported in this patient population.
Common (1% to 10%): Accidental injury, pain
Uncommon (0.1% to 1%): Ear pain, face edema, fever, hernia, malaise, otitis externa, otitis media, tinnitus
Rare (less than 0.1%): Hyperacusis
Frequency not reported: Asthenia
CardiovascularCommon (1% to 10%): Chest pain, peripheral edema
Uncommon (0.1% to 1%): Heat stroke, hypertension
Rare (less than 0.1%): Thrombophlebitis
ImmunologicA dose-response relationship appears to exist for infection.
Common (1% to 10%): Infection, viral infection
Rare (less than 0.1%): Herpes zoster
Frequency not reported: Flu syndrome
HypersensitivityUncommon (0.1% to 1%): Allergic reaction
EndocrineCommon (1% to 10%): Gynecomastia
MusculoskeletalUncommon (0.1% to 1%): Arthritis, bursitis, joint disorder, joint pain, joint swelling, joint stiffness, leg cramps, myasthenia, neck rigidity, twitching
Rare (less than 0.1%): Arthrosis, myopathy
Frequency not reported: Back pain, myalgia
MetabolicUncommon (0.1% to 1%): Anorexia, hypercholesterolemia, increased appetite, thirst, weight gain, weight loss
Rare (less than 0.1%): Dehydration, gout, hyperlipemia, hypokalemia
RespiratoryUncommon (0.1% to 1%): Asthma, bronchitis, dyspnea, epistaxis, hiccup, laryngitis
Frequency not reported: Pharyngitis, rhinitis
OcularUncommon (0.1% to 1%): Conjunctivitis, dry eyes
Rare (less than 0.1%): Iritis, mydriasis, photophobia, ptosis
RenalUncommon (0.1% to 1%): Kidney calculus, kidney pain
Rare (less than 0.1%): Oliguria, pyelonephritis
HematologicUncommon (0.1% to 1%): Anemia, lymphadenopathy
HepaticUncommon (0.1% to 1%): Cholelithiasis
Rare (less than 0.1%): Hepatitis, hepatomegaly, liver damage
OncologicUncommon (0.1% to 1%): Breast neoplasm
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Eszopiclone (www.drugs.com/eszopiclone.html).
March 11, 2021
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