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Note: This document contains side effect information about asparaginase erwinia chrysanthemi. Some of the dosage forms listed on this page may not apply to the brand name Erwinaze.
Common side effects of Erwinaze include: anaphylaxis. Other side effects include: pancreatitis and severe hypersensitivity reaction. See below for a comprehensive list of adverse effects.
Applies to asparaginase erwinia chrysanthemi: injection powder for solution
Along with its needed effects, asparaginase erwinia chrysanthemi (the active ingredient contained in Erwinaze) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking asparaginase erwinia chrysanthemi:
Some side effects of asparaginase erwinia chrysanthemi may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Applies to asparaginase erwinia chrysanthemi: injectable powder for injection
Most common adverse reactions were systemic hypersensitivity, hyperglycemia, abnormal transaminases, fever, pancreatitis, local reactions, vomiting, nausea, thrombosis, hyperbilirubinemia, abdominal pain/discomfort, and diarrhea.
Very common (10% or more): Systemic hypersensitivity (14%)
Very rare (less than 0.01%): Anaphylaxis
Common (1% to 10%): Pancreatitis, vomiting, nausea, abdominal pain/discomfort, diarrhea, serum amylases increased, serum lipase increased
Common (1% to 10%): Lethargy, somnolence, confusion, dizziness, neurotoxicity, convulsions, headache
Rare (less than 0.1%): Dysphasia, dysphagia, CNS depression, coma
Common (1% to 10%): Rash, urticarial, pruritus, erythema, facial edema
Common (1% to 10%): Transaminases abnormal, hyperbilirubinemia, alkaline phosphatase increased, cholesterol increased
Rare (less than 0.1%): Hepatic failure
Frequency not reported: Hepatomegaly, cholestatic jaundice
Common (1% to 10%): Hypofibrinogenemia, asymptomatic coagulopathy
Very rare (less than 0.01%): Neutropenia, febrile neutropenia, thrombocytopenia
Frequency not reported: clotting factor decreased, antithrombin III decreased, protein C decreased, protein S decreased, fibrinogen decreased
Common (1% to 10%): Thrombosis, pallor
Very rare (less than 0.01%): Hemorrhage
Frequency not reported: Hypertension
Common (1% to 10%): Hyperglycemia
Uncommon (0.1% to 1%): Hyperlipidemia
Rare (0.01% to 0.1%): Diabetic ketoacidosis
Very rare (less than 0.01%): Hyperammonemia
Common (1% to 10%): Local reactions
Common (1% to 10%): Fever
Very rare (less than 0.01%): Myalgia, reactive arthritis
Frequency not reported: Extremity pain
Very rare (less than 0.01%): Life-threatening sepsis
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