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Erivedge

Generic Name: vismodegib (VIS moe DEG ib)
Brand Names: Erivedge
Erivedge (vismodegib) is used to treat basal cell carcinoma that has spread to other parts of the body. Includes Erivedge side effects, interactions and indications.
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Drug Information:
Erivedge (vismodegib) is a cancer medicine that interferes with the growth of certain cancer cells in the body. Erivedge is used to treat basal cell carcinoma that has spread to other parts of the body. Erivedge may also be used for purposes not listed in this medication guide. Do not use Erivedge if you are pregnant, or if you are a man and your sexual partner is pregnant. Erivedge use by either parent may cause severe birth defects or death of a baby. For Women: Use effective birth control to prevent pregnancy while you are using this medicine and for at least 24 months after your last dose. Call your doctor at once if you quit using birth control, if your period is late, or if you think you might be pregnant. Learn more

Erivedge Side Effects

Erivedge Side Effects

Note: This document contains side effect information about vismodegib. Some of the dosage forms listed on this page may not apply to the brand name Erivedge.

For the Consumer

Applies to vismodegib: oral capsule

Warning

Oral route (Capsule)

Vismodegib can result in embryo-fetal death or severe birth defects. Animal data indicate vismodegib is embryotoxic and teratogenic. Pregnancy status should be verified 7 days prior to treatment initiation. Advise female patients of the need for contraception during and after vismodegib therapy. Advise male patients of the potential risk of vismodegib exposure through semen and recommend use of condoms with a pregnant partner or female partner of reproductive potential.

Along with its needed effects, vismodegib (the active ingredient contained in Erivedge) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vismodegib:

Less common

  • Bloody or cloudy urine
  • coma
  • confusion
  • convulsions
  • decreased urine output
  • dizziness
  • dry mouth
  • fast or irregular heartbeat
  • headache
  • increased thirst
  • muscle pain or cramps
  • nausea or vomiting
  • pain in the lower back or side
  • shortness of breath
  • swelling of the face, ankles, or hands
  • thirst
  • unusual tiredness or weakness

Some side effects of vismodegib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Absent, missed, or irregular menstrual periods
  • change in taste
  • decreased appetite
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • hair loss or thinning of the hair
  • loss of taste
  • muscle spasm or stiffness
  • pain in the joints
  • stopping of menstrual bleeding
  • weight loss

For Healthcare Professionals

Applies to vismodegib: oral capsule

Dermatologic

Very common (10% or more): Alopecia (64%), pruritus

Common (1% to 10%): Rash, madarosis, abnormal hair growth

Gastrointestinal

Very common (10% or more): Nausea (31%), diarrhea (29%), constipation (21%), vomiting (14%)

Common (1% to 10%): Dyspepsia, upper abdominal pain, abdominal pain

General

The most frequent adverse drug reactions reported were muscle spasms (75%), alopecia (65%), dysgeusia (57%), weight loss (49%), fatigue (45%), and nausea (35%).

Genitourinary

Very common (10% or more): Amenorrhea

Metabolic

Very common (10% or more): Weight loss (45%), decreased appetite (25%)

Common (1% to 10%): Dehydration, hyponatremia, azotemia, and hypokalemia

Musculoskeletal

Very common (10% or more): Muscle spasms (72%), arthralgia (16%)

Common (1% to 10%): Pain in extremity, back pain, musculoskeletal chest pain, myalgia, flank pain, musculoskeletal pain

Nervous system

Very common (10% or more): Dysgeusia (55%), ageusia (11%)

Common (1% to 10%): Hypogeusia

Hepatic

Common (1% to 10%): Hepatic enzymes increased

Other

Very common (10% or more): Fatigue (40%)

Common (1% to 10%): Pain, asthenia

Renal

Common (1% to 10%): Elevated blood urea nitrogen

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Erivedge (www.drugs.com/erivedge.html).