Please wait...


Generic Name: abacavir and lamivudine (a BAK a veer and la MIV yoo deen)
Brand Names: Epzicom
Epzicom is used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS). Learn about side effects, interactions and indications.

Average Savings for abacavir sulfate/lamivudi (generic): 64.56%
  • Prescription Settings
  • X
  • Local Pharmacy Pickup available at . Pick up your medication at any of our participating pharmacies.
  • Mail Order Home Delivery available at , the easiest way to receive your medications.
  • Learn more

Epzicom Coupons & Prices

Set your location
for drug prices near you

Enter your zip code

Please wait while the prices are loaded...
Click here to try again.

Don’t see your pharmacy listed? Most pharmacies accept our discounts, so have your pharmacist enter this coupon to see if you will save money:

Drug Information:
Epzicom contains a combination of abacavir and Lamivudine. Abacavir and Lamivudine are antiviral medicines that prevent human immunodeficiency virus (HIV) from multiplying in your body. Epzicom is used to treat HIV, which can cause the acquired immunodeficiency syndrome (AIDS). Epzicom is not a cure for HIV or AIDS. Epzicom can cause severe or fatal side effects. Follow all directions on your medicine label and package. Tell each of your healthcare prOviders about all your medical conditions, allergies, and all medicines you use. Learn more

Pickup / Home Delivery

USARx offers multiple ways to purchase this medication. Choose the Best option for you!

  • Guaranteed Price
    Local Pharmacy Pickup

    Pay this amount and pick up your prescription at ANY Retail pharmacy of your choice! Walgreens, CVS, Walmart, etc.

  • 30-day supply
    90-day supply
    Mail Order Home Delivery

    The easiest way to receive your medications.

Epzicom Side Effects

Note: This document contains side effect information about abacavir / lamivudine. Some of the dosage forms listed on this page may not apply to the brand name Epzicom.

In Summary

More frequent side effects include: hypersensitivity reaction. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to abacavir / lamivudine: oral tablet


Oral route (Tablet)

Hypersensitivity Reactions:Serious and sometimes fatal hypersensitivity reactions, with multiple organ involvement, have occurred with abacavir, a component of the abacavir and lamivudine combination. Patients who carry the HLA-B*5701 allele are at a higher risk of a hypersensitivity reaction to abacavir; although, hypersensitivity reactions have occurred in patients who do not carry the HLA-B*5701 allele.The abacavir and lamivudine combination is contraindicated in patients with a prior hypersensitivity reaction to abacavir and in HLA-B*5701-positive patients. All patients should be screened for the HLA-B*5701 allele prior to initiating therapy with abacavir and lamivudine or reinitiation of therapy with abacavir and lamivudine, unless patients have a previously documented HLA-B*5701 allele assessment. Discontinue abacavir and lamivudine combination immediately if a hypersensitivity reaction is suspected, regardless of HLA-B*5701 status and even when other diagnoses are possible.Following a hypersensitivity reaction to abacavir and lamivudine combination, never restart abacavir and lamivudine or any other abacavir-containing product because more severe symptoms, including death, can occur within hours. Similar severe reactions have also occurred rarely following the reintroduction of abacavir-containing products in patients who have no history of abacavir hypersensitivity.Exacerbations of Hepatitis B:Severe acute exacerbations of hepatitis B have been reported in patients who are co-infected with hepatitis B virus (HBV) and human immunodeficiency virus (HIV-1) and have discontinued lamivudine, which is a component of abacavir and lamivudine combination. Hepatic function should be monitored closely with both clinical and laboratory follow-up for at least several months in patients who discontinue abacavir and lamivudine and are co-infected with HIV-1 and HBV. If appropriate, initiation of anti-hepatitis B therapy may be warranted.

Along with its needed effects, abacavir / lamivudine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking abacavir / lamivudine:

More common

  • Abdominal or stomach pain
  • cough
  • diarrhea
  • fever
  • headache
  • nausea
  • numbness or tingling of the face, feet, or hands
  • pain in the joints
  • pain in the muscles
  • skin rash
  • sore throat
  • swelling of the feet or lower legs
  • unusual feeling of discomfort or illness
  • unusual tiredness or weakness
  • vomiting

Incidence not known

  • Blistering, peeling, or loosening of the skin
  • bloating
  • burning, numbness, tingling, or painful sensations
  • chest pain
  • chills
  • constipation
  • convulsions
  • dark urine
  • decreased appetite
  • diarrhea
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • fast, shallow breathing
  • feeling of fullness
  • general feeling of discomfort
  • hives or welts, itching
  • indigestion
  • light-colored stools
  • loss of appetite
  • loss of bladder control
  • muscle cramping
  • muscle spasm or jerking of all extremities
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pale skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red, irritated eyes
  • redness of the skin
  • red skin lesions, often with a purple center
  • sleepiness
  • sores, ulcers, or white spots on the lips or in the mouth
  • sudden loss of consciousness
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • tightness in the chest
  • troubled breathing with exertion
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • upper right abdominal or stomach pain
  • weakness in the arms, hands, legs, or feet
  • yellow eyes and skin

Some side effects of abacavir / lamivudine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abnormal dreams
  • burning feeling in the chest or stomach
  • fear or nervousness
  • feeling of constant movement of self or surroundings
  • lightheadedness
  • sensation of spinning
  • severe and throbbing headache
  • stomach upset
  • tenderness in the stomach area
  • trouble sleeping

Incidence not known

  • Abnormal breathing sounds
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • dry mouth
  • flushed, dry skin
  • fruit-like breath odor
  • gaining weight around your neck, upper back, breast, face, or waist
  • hair loss
  • increased hunger
  • increased thirst
  • increased urination
  • muscle weakness
  • sweating
  • swelling or inflammation of the mouth
  • thinning of the hair
  • unexplained weight loss

For Healthcare Professionals

Applies to abacavir / lamivudine: oral tablet


In 1 study, once- or twice-daily abacavir was used in combination with lamivudine and efavirenz. Patients receiving once-daily abacavir had a significantly higher incidence of severe drug hypersensitivity reactions and severe diarrhea than patients on the twice-daily regimen.

Many of the side effects listed occurred commonly in patients with abacavir hypersensitivity (e.g., nausea, vomiting, diarrhea, fever, lethargy, rash).


Serious and sometimes fatal hypersensitivity reactions have been reported with abacavir. Such reactions have included multi-organ failure and anaphylaxis and usually occurred within the first 6 weeks of abacavir therapy (median onset: 9 to 11 days); however, abacavir hypersensitivity reactions have occurred any time during therapy.

Patients with the human leukocyte antigen subtype B*5701 (HLA-B*5701) allele are at higher risk of abacavir hypersensitivity reactions; however, such reactions have occurred in patients without the HLA-B*5701 allele. Abacavir hypersensitivity was reported in about 8% of patients in 9 clinical trials with abacavir-containing products where patients were not screened for the HLA-B*5701 allele; incidence of suspected abacavir hypersensitivity reactions was 1% in clinical trials where HLA-B*5701 carriers were excluded.

Abacavir hypersensitivity reactions have been characterized by at least 2 of the following key signs/symptoms: (1) fever; (2) rash; (3) gastrointestinal symptoms (including nausea, vomiting, diarrhea, abdominal pain); (4) constitutional symptoms (including generalized malaise, fatigue, achiness); (5) respiratory symptoms (including dyspnea, cough, pharyngitis). Almost all reactions have included fever and/or rash (usually maculopapular or urticarial); however, reactions also reported without fever or rash. Signs/symptoms reported in at least 10% of patients with hypersensitivity reaction have included rash, nausea, vomiting, diarrhea, abdominal pain, dyspnea, cough, fever, fatigue/lethargy, malaise, headache, elevated liver function tests, and myalgia. Other signs/symptoms of hypersensitivity have included mouth ulceration, sore throat, adult respiratory distress syndrome, respiratory failure, edema, lymphadenopathy, hypotension, conjunctivitis, anaphylaxis, paresthesia, lymphopenia, hepatitis, liver failure, myolysis, arthralgia, elevated creatine phosphokinase, elevated creatinine, renal failure, abnormal chest x-ray findings (mainly infiltrates, which were localized), and death.

Symptoms of abacavir hypersensitivity reaction worsened with continued therapy and generally resolved when abacavir was discontinued. Restarting abacavir after a hypersensitivity reaction has resulted in more severe symptoms within hours and included life-threatening hypotension and death. Rarely, life-threatening reactions have occurred within hours after restarting abacavir in patients who stopped it for reasons other than symptoms of hypersensitivity (or who stopped it with only 1 key symptom of hypersensitivity).

Abacavir and lamivudine:

-Common (1% to 10%): Drug hypersensitivity

-Postmarketing reports: Sensitization reactions (including anaphylaxis)


-Common (1% to 10%): Hypersensitivity reactions (including fever, rash [maculopapular, urticarial], nausea, vomiting, diarrhea, abdominal pain, pharyngitis, malaise, fatigue, achiness, dyspnea, cough, lethargy, headache, myalgia, arthralgia, myolysis, edema, abnormal chest x-ray findings [mainly localized infiltrates], paresthesia, anaphylaxis, hepatitis, liver failure, renal failure, hypotension, sore throat, adult respiratory distress syndrome, respiratory failure, death, lymphadenopathy, mucous membrane lesions [conjunctivitis, mouth ulceration], erythema multiforme, elevated liver function tests, elevated creatine phosphokinase, elevated creatinine, lymphopenia)


-Frequency not reported: Anaphylactoid reactions


Abacavir and lamivudine:

-Common (1% to 10%): Elevated ALT, elevated AST

-Uncommon (0.1% to 1%): Abnormal bilirubin

-Frequency not reported: Severe hepatomegaly with steatosis

-Postmarketing reports: Hepatic steatosis, posttreatment exacerbation of hepatitis B


-Frequency not reported: Liver function test abnormalities, elevated GGT


-Uncommon (0.1% to 1%): Transient elevations in liver enzymes (AST, ALT)

-Rare (less than 0.1%): Hepatitis

-Frequency not reported: Elevated bilirubin, elevated hepatic enzymes, hepatic decompensation, severe acute exacerbations of hepatitis

Lactic acidosis and severe hepatomegaly with steatosis (including fatal cases) have been reported with the use of nucleoside analogs.

Elevated GGT was observed in the expanded access program for abacavir.

Hepatic decompensation (some fatal) has been reported in patients coinfected with HIV-1 and hepatitis C virus receiving combination antiretroviral therapy for HIV-1 and interferon alfa with or without ribavirin.

Severe acute exacerbations of hepatitis have been reported in patients with hepatitis B after discontinuation of lamivudine.


Abacavir and lamivudine:

-Common (1% to 10%): Nausea, diarrhea, abdominal pain/gastritis, abnormal amylase

-Postmarketing reports: Stomatitis


-Common (1% to 10%): Nausea, vomiting, diarrhea

-Postmarketing reports: Pancreatitis (rare)


-Common (1% to 10%): Nausea, vomiting, abdominal pain/cramps, diarrhea

-Frequency not reported: Elevated lipase

-Postmarketing reports: Elevated serum amylase (rare), pancreatitis (rare)

Pancreatitis was observed in the expanded access program for abacavir.


Suspected Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have been reported in patients using abacavir primarily in combination with agents known to be associated with SJS and TEN, respectively.

Cases of erythema multiforme, SJS, or TEN have been reported very rarely when abacavir hypersensitivity could not be ruled out.

Abacavir and lamivudine:

-Common (1% to 10%): Rash

-Postmarketing reports: Alopecia, erythema multiforme, Stevens-Johnson syndrome, urticaria


-Frequency not reported: Sweet's syndrome

-Postmarketing reports: Rash without systemic symptoms (common), erythema multiforme (very rare), Stevens-Johnson syndrome (very rare), toxic epidermal necrolysis (very rare)


-Common (1% to 10%): Rash

-Rare (less than 0.1%): Angioedema

-Frequency not reported: Pruritus, urticaria

-Postmarketing reports: Alopecia (common)


Abacavir and lamivudine:

-Common (1% to 10%): Abnormal absolute neutrophils

-Uncommon (0.1% to 1%): Abnormal hemoglobin, abnormal platelets, abnormal WBC

-Postmarketing reports: Aplastic anemia, anemia (including pure red cell aplasia and severe anemias progressing on therapy), lymphadenopathy, splenomegaly


-Frequency not reported: Anemia, neutropenia, agranulocytosis


-Uncommon (0.1% to 1%): Thrombocytopenia, neutropenia, anemia

-Postmarketing reports: Pure red cell aplasia (very rare)

Agranulocytosis has been reported after the addition of abacavir to a multi-drug regimen.

Occasionally, neutropenia and anemia reported with lamivudine were severe.

Nervous system

Abacavir and lamivudine:

-Common (1% to 10%): Headache/migraine, dizziness/vertigo

-Postmarketing reports: Peripheral neuropathy, paresthesia, seizures


-Common (1% to 10%): Headache


-Common (1% to 10%): Headache

-Postmarketing reports: Paresthesia (very rare), peripheral neuropathy (very rare)


The emergence of lamivudine-resistant HBV has been reported in HIV-1/HBV-coinfected patients using lamivudine-containing antiretroviral regimens.

Abacavir and lamivudine:

-Common (1% to 10%): Fatigue/malaise, pyrexia

-Postmarketing reports: Weakness


-Common (1% to 10%): Fever, lethargy, fatigue


-Common (1% to 10%): Fatigue, malaise, fever

-Frequency not reported: Drug-resistant hepatitis B virus (HBV)


Abacavir and lamivudine:

-Common (1% to 10%): Insomnia, depression/depressed mood, abnormal dreams, anxiety


-Common (1% to 10%): Insomnia


Lactic acidosis and severe hepatomegaly with steatosis (including fatal cases) have been reported with the use of nucleoside analogs.

Redistribution/accumulation of body fat has been reported with antiretroviral therapy; causality has not been established.

Abacavir and lamivudine:

-Common (1% to 10%): Abnormal triglycerides

-Uncommon (0.1% to 1%): Abnormal alkaline phosphatase, abnormal glucose, abnormal sodium

-Frequency not reported: Lactic acidosis

-Postmarketing reports: Hyperglycemia, redistribution/accumulation of body fat


-Common (1% to 10%): Anorexia

-Frequency not reported: Elevated blood glucose, elevated triglycerides

-Postmarketing reports: Hyperlactatemia (common), lactic acidosis (rare)


-Postmarketing reports: Hyperlactatemia (common), lactic acidosis (rare)

Combination antiretroviral therapy:

-Frequency not reported: Redistribution/accumulation of body fat (including central obesity, dorsocervical fat enlargement, peripheral wasting, facial wasting, breast enlargement, "cushingoid appearance"), metabolic abnormalities (e.g., hypertriglyceridemia, hypercholesterolemia, insulin resistance, hyperglycemia, hyperlactatemia)


Abacavir and lamivudine:

-Uncommon (0.1% to 1%): Abnormal creatine phosphokinase (CPK)

-Postmarketing reports: Muscle weakness, CPK elevation, rhabdomyolysis


-Frequency not reported: Elevated CPK


-Postmarketing reports: Arthralgia (common), muscle disorders (common), rhabdomyolysis (rare)

Combination antiretroviral therapy:

-Frequency not reported: Osteonecrosis



-Postmarketing reports: Myocardial infarction (MI)

An observational study investigating the rate of MI in patients on combination antiretroviral therapy showed an increased risk of MI with the use of abacavir within the previous 6 months. A sponsor-conducted pooled analysis of clinical trials showed no excess risk of MI in abacavir-treated patients as compared with control subjects. Overall, available data from the observational cohort and from clinical trials were inconclusive.


Frequency not reported: Immune reconstitution/reactivation syndrome, autoimmune disorders in the setting of immune reconstitution (e.g., Graves' disease, polymyositis, Guillain-Barre syndrome)


Abacavir and lamivudine:

-Uncommon (0.1% to 1%): Abnormal creatinine


Abacavir and lamivudine:

-Postmarketing reports: Abnormal breath sounds/wheezing


-Common (1% to 10%): Cough, nasal symptoms

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Epzicom (www.drugs.com/epzicom.html).