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Eplerenone Prescription
Generic Name: eplerenone (ep LER e none)
Brand Name: Inspra
Physician reviewed eplerenone patient information - includes eplerenone description, dosage and directions.

Average Savings for eplerenone (generic): 28.49%
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Eplerenone Drug Information:

Eplerenone is used to lower the risk of death from heart failure after a heart attack. Eplerenone is also used to treat high blood pressure (hypertension). Eplerenone may also be used for purposes not listed in this medication guide. You may not be able to take eplerenone if you have severe kidney disease, high potassium levels in your blood, or type 2 Diabetes with increased levels of albumin (a protein) in your urine. Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together. Learn more

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Eplerenone Side Effects

In Summary

Commonly reported side effects of eplerenone include: cough, diarrhea, fatigue, and flu-like symptoms. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to eplerenone: oral tablet

Along with its needed effects, eplerenone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking eplerenone:

Less common

  • Excess of cholesterol in the blood
  • excess of triglycerides in the blood

Incidence not known

  • Abdominal or stomach pain
  • arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • difficulty with breathing
  • dizziness
  • fast or irregular heartbeat
  • headache
  • irregular heartbeat
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • nausea
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pain or discomfort in the arms, jaw, back, or neck
  • rash
  • shortness of breath
  • sweating
  • vomiting
  • weakness or heaviness of the legs

Some side effects of eplerenone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Abnormal vaginal bleeding
  • breast pain
  • chills
  • cloudy urine
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • swelling of the breasts or breast soreness in both females and males
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to eplerenone: oral tablet


Adverse reactions that occurred more frequently in patients treated with this drug compared to placebo were hyperkalemia and increased creatinine.


Very common (10% or more): Potassium greater than 5.5 mEq/L (up to 15.6%)

Common (1% to 10%): Potassium less than 3.5 mEq/L, potassium 6 mEq/L or greater


Common (1% to 10%): Creatinine increased

Frequency not reported: Renal function abnormal


Frequency not reported: Myocardial infarction, angina pectoris

Nervous system

Frequency not reported: Headache, dizziness


Frequency not reported: Gynecomastia


Frequency not reported: Gamma-glutamyltransferase increased


Postmarketing reports: Angioneurotic edema, rash


Frequency not reported: Abnormal vaginal bleeding

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Eplerenone (www.drugs.com/mtm/eplerenone.html).