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Note: This document contains side effect information about sacubitril / valsartan. Some of the dosage forms listed on this page may not apply to the brand name Entresto.
In SummaryCommon side effects of Entresto include: hyperkalemia, hypotension, and increased serum creatinine. Other side effects include: acute renal failure, and renal failure syndrome. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to sacubitril / valsartan: oral tablet
Oral route (Tablet)
Drugs that act directly on the renin-angiotensin system may cause fetal injury or death. Discontinue use immediately if pregnancy is detected.
Along with its needed effects, sacubitril/valsartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking sacubitril / valsartan:
More common
Less common
Rare
Some side effects of sacubitril / valsartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
For Healthcare Professionals
Applies to sacubitril / valsartan: oral tablet
GeneralThe most common adverse reactions were hypotension, hyperkalemia, cough, dizziness, and renal failure.
CardiovascularVery common (10% or more): Hypotension (18%)
Common (1% to 10%): Orthostasis
MetabolicVery common (10% or more): Potassium greater than 5.5 mEq/L (16%), hyperkalemia (12%)
RenalVery common (10% or more): Serum creatinine increased greater than 50% (16%)
Common (1% to 10%): Renal failure/acute renal failure
RespiratoryCommon (1% to 10%): Cough
Nervous systemCommon (1% to 10%): Dizziness
DermatologicUncommon (0.1% to 1%): Angioedema
Postmarketing reports: Rash, pruritus
The incidence of angioedema was 2.4% in Black patients.
HematologicCommon (1% to 10%): Hemoglobin/hematocrit decreased greater than 20%
OtherCommon (1% to 10%): Falls
ImmunologicPostmarketing reports: Hypersensitivity, anaphylactic reaction
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Entresto (www.drugs.com/entresto.html).
October 2, 2020
October 2, 2020
July 30, 2015
May 17, 2022
May 17, 2022
May 17, 2022