Entresto

Note: This document contains side effect information about sacubitril / valsartan. Some of the dosage forms listed on this page may not apply to the brand name Entresto.

Common side effects of Entresto include: hyperkalemia, hypotension, and increased serum creatinine. Other side effects include: acute renal failure, and renal failure syndrome. See below for a comprehensive list of adverse effects.

Applies to sacubitril / valsartan: oral tablet

Along with its needed effects, sacubitril/valsartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sacubitril / valsartan:

More common

• Abdominal or stomach pain
• blurred vision
• confusion
• difficult breathing
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• irregular heartbeat
• nausea or vomiting
• nervousness
• numbness or tingling in the hands, feet, or lips
• sweating
• unusual tiredness or weakness
• weakness or heaviness of the legs

Less common

• Bloody urine
• decreased frequency or amount of urine
• increased thirst
• loss of appetite
• lower back or side pain
• swelling of the face, fingers, or lower legs
• weight gain

Rare

• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Some side effects of sacubitril / valsartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Cough
• dizziness

Applies to sacubitril / valsartan: oral tablet

The most common adverse reactions were hypotension, hyperkalemia, cough, dizziness, and renal failure.

Very common (10% or more): Hypotension (18%)

Common (1% to 10%): Orthostasis

Very common (10% or more): Potassium greater than 5.5 mEq/L (16%), hyperkalemia (12%)

Very common (10% or more): Serum creatinine increased greater than 50% (16%)

Common (1% to 10%): Renal failure/acute renal failure

Common (1% to 10%): Cough

Common (1% to 10%): Dizziness

Uncommon (0.1% to 1%): Angioedema

Postmarketing reports: Rash, pruritus

The incidence of angioedema was 2.4% in Black patients.

Common (1% to 10%): Hemoglobin/hematocrit decreased greater than 20%

Common (1% to 10%): Falls

Postmarketing reports: Hypersensitivity, anaphylactic reaction