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Effient

Generic Name: prasugrel (PRA soo grel)
Brand Names: Effient
Effient is used to prevent blood clots forming in acute coronary syndrome patients. Learn about side effects, interactions and indications.
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Drug Information:
Effient (Prasugrel) helps to prevent platelets in your blood from sticking together and forming a blood clot. An unwanted blood clot can occur with certain heart or blood vessel conditions. Effient is used to prevent blood clots in people with acute coronary syndrome who are undergoing a procedure after a recent heart attack. Effient may also be used for other purposes not listed in this medication guide. You should not take Effient if you have active bleeding such as a stomach ulcer or bleeding in the brain, if you have ever had a stroke or "mini-stroke", or if you are scheduled to have surgery, especially heart bypass surgery. Learn more

Effient Side Effects

Effient Side Effects

Note: This document contains side effect information about prasugrel. Some of the dosage forms listed on this page may not apply to the brand name Effient.

For the Consumer

Applies to prasugrel: oral tablet

Warning

Oral route (Tablet)

Prasugrel can cause significant and sometimes fatal bleeding. Do not use prasugrel in patients with active pathological bleeding or a history of transient ischemic attack or stroke. Risk factors for bleeding include body weight of less than 60 kg, propensity to bleed, and concomitant use of medications that increase the risk of bleeding (eg, warfarin, heparin, fibrinolytics, chronic use of NSAIDs). Prasugrel is not recommended in patients 75 years of age or older, except for high-risk situations (diabetes, history of prior myocardial infarction). Do not start prasugrel in patients likely to undergo urgent CABG, and discontinue at least 7 days prior to any surgery. If possible, manage bleeding without discontinuing prasugrel, as discontinuation in the first few weeks after acute coronary syndrome may increase risk for subsequent cardiovascular events.

Along with its needed effects, prasugrel (the active ingredient contained in Effient) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking prasugrel:

More common

  • Blurred vision
  • dizziness
  • headache
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat

Less common

  • Black, tarry stools
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • chest pain or discomfort
  • chills
  • cough
  • difficult or labored breathing
  • fainting
  • fever
  • irregular heartbeat
  • lightheadedness, dizziness, or fainting
  • painful or difficult urination
  • rapid weight gain
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • tightness in the chest
  • tingling of the hands or feet
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss

Incidence not known

  • Change in mental status
  • dark or bloody urine
  • difficulty with speaking
  • fever
  • pale color of the skin
  • pinpoint red spots on the skin
  • seizures
  • weakness
  • yellow eyes or skin

Some side effects of prasugrel may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Back pain
  • diarrhea
  • nausea
  • pain in the arms or legs
  • rash

For Healthcare Professionals

Applies to prasugrel: oral tablet

General

The most common adverse reaction leading to drug discontinuation was bleeding.

Hematologic

Very common (10% or more): CABG (coronary artery bypass graft surgery)-related TIMI (Thrombolysis in Myocardial Infarction) Major (clinically overt bleeding associated with hemoglobin decreased by 5 g/dL or more, or intracranial hemorrhage) or Minor (overt bleeding associated with hemoglobin decreased by 3 to less than 5 g/dL) bleeding (14.1%), non-CABG-related TIMI Major or Minor bleeding in patients less than 60 kg (10.1%)

Common (1% to 10%): Non-CABG-related TIMI Major bleeding, non-CABG-related TIMI Minor bleeding, non-CABG-related life-threatening TIMI Major bleeding, non-CABG-related TIMI fatal bleeding in patients 75 years or older, CABG-related reoperation TIMI Major bleeding, CABG-related TIMI Major bleeding requiring transfusion of 5 units or more, anemia, leukopenia (less than 4 x 10(9) WBC/L)

Uncommon (0.1% to 1%): Non-CABG-related fatal TIMI Major bleeding, non-CABG-related symptomatic intracranial hemorrhage (ICH), non-CABG-related TIMI Major bleeding requiring inotropes, non-CABG-related TIMI Major bleeding requiring surgical intervention, non-CABG-related TIMI Major bleeding requiring transfusion of 4 units or more, CABG-related fatal TIMI Major bleeding, post-procedural hemorrhage

Rare (less than 0.1%): Severe thrombocytopenia

Postmarketing reports: Thrombocytopenia

Cardiovascular

Common (1% to 10%): Hypertension, hypotension, atrial fibrillation, bradycardia, hematoma

Uncommon (0.1% to 1%): Retroperitoneal hemorrhage, pericardial effusion/hemorrhage/tamponade

Very rare (less than 0.01%): Thrombotic thrombocytopenic purpura

Gastrointestinal

Common (1% to 10%): Gastrointestinal hemorrhage, nausea, diarrhea

Uncommon (0.1% to 1%): Rectal hemorrhage, gingival bleeding, hematochezia

Dermatologic

Common (1% to 10%): Rash, contusion, ecchymosis

Uncommon (0.1% to 1%): Subcutaneous hematoma

Rare (less than 0.1%): Angioedema

Respiratory

Common (1% to 10%): Dyspnea, cough, epistaxis

Uncommon (0.1% to 1%): Hemoptysis

Musculoskeletal

Common (1% to 10%): Back pain, non-cardiac chest pain, pain in extremity

Local

Common (1% to 10%): Vessel puncture site hematoma, puncture site hemorrhage

Nervous system

Common (1% to 10%): Headache, dizziness

Metabolic

Common (1% to 10%): Hypercholesterolemia/hyperlipidemia, peripheral edema

Other

Common (1% to 10%): Fatigue, pyrexia

Genitourinary

Common (1% to 10%): Hematuria

Oncologic

Common (1% to 10%): Newly-diagnosed malignancies

Immunologic

Uncommon (0.1% to 1%): Allergic reactions

Rare (less than 0.1%): Hypersensitivity, anaphylaxis

Hepatic

Uncommon (0.1% to 1%): Abnormal hepatic function

Ocular

Uncommon (0.1% to 1%): Eye hemorrhage

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Effient (www.drugs.com/effient.html).