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Dysport

Generic Name: abobotulinumtoxinA (A boe BOT ue LYE num TOX in A)
Brand Names: Dysport
Dysport (abobotulinumtoxinA) is used to treat cervical dystonia, glabellar lines and upper limb spasticity. Includes Dysport side effects, interactions and indications.
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Drug Information:
Dysport is an injection containing abobotulinumtoxinA (Botulinum toxin type A). AbobotulinumtoxinA is made from the bacteria that causes botulism. Botulinum toxin blocks nerve activity in the muscles, causing a temporary reduction in muscle activity. Dysport is used to treat cervical dystonia (severe spasms in the neck muscles). Dysport is also used to treat muscle spasms (stiffness) in the upper limbs (elbows, wrists, fingers) or lower limbs (ankles, toes). Dysport is also used to temporarily lessen the appearance of facial wrinkles. Learn more

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Dysport Side Effects

Note: This document contains side effect information about abobotulinumtoxinA. Some of the dosage forms listed on this page may not apply to the brand name Dysport.

In Summary

Common side effects of Dysport include: dysphagia, headache, myasthenia, nasopharyngitis, voice disorder, and xerostomia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to abobotulinumtoxinA: intramuscular powder for solution

Warning

Intramuscular route (Powder for Solution)

The effects of abobotulinumtoxinA and all botulinum toxin products may spread from the area of injection to produce symptoms consistent with botulinum toxin effects. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening and there have been reports of death. The risk of symptoms is probably greatest in children treated for spasticity but symptoms can also occur in adults, particularly in those patients who have underlying conditions that would predispose them to these symptoms. In unapproved uses, including upper limb spasticity in children, and in approved indications, spread of effect has reported at doses comparable to or lower than the maximum recommended total dose.

Along with its needed effects, abobotulinumtoxinA (the active ingredient contained in Dysport) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking abobotulinumtoxinA:

More common

  • Difficulty with swallowing or speaking
  • hoarseness
  • muscle or bone pain
  • muscle weakness
  • seizures
  • sore throat
  • voice changes

Less common

  • Blistering, burning, crusting, dryness, or flaking of the skin
  • body aches or pain
  • chills
  • cough
  • cough producing mucus
  • diarrhea
  • difficult or labored breathing
  • ear congestion
  • fever
  • general feeling of discomfort or illness
  • headache
  • itching, scaling, severe redness, soreness, or swelling of the skin
  • joint pain
  • loss of appetite
  • loss of voice
  • muscle aches and pains
  • nausea
  • shivering
  • sneezing
  • stiff muscles
  • stuffy or runny nose
  • sweating
  • tightness in the chest
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting

Incidence not known

  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • dizziness
  • fast heartbeat
  • flushing or redness of the skin
  • hives, itching, rash
  • partial or slight paralysis of the face
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • unusually warm skin

Some side effects of abobotulinumtoxinA may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • blurred vision
  • decreased vision
  • double vision
  • dry eyes
  • dry mouth
  • eye pain
  • itching of the eyes
  • problems with focusing of the eyes
  • seeing double

Less common

  • Drooping upper eyelids
  • pain or tenderness around the eyes and cheekbones

Incidence not known

  • Change in color vision
  • difficulty seeing at night
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • increased sensitivity of the eyes to sunlight
  • sensation of spinning

For Healthcare Professionals

Applies to abobotulinumtoxinA: injectable powder for injection, intramuscular powder for injection

General

The most commonly occurring side effects have included muscular weakness, dysphagia, dry mouth, injection site pain and discomfort, fatigue, headache, and nasopharyngitis.

Nervous system

Very common (10% or more): Dysphonia (up to 28%), headache (11%), facial paresis (up to 11%)

Common (1% to 10%): Dizziness, convulsion, syncope, hypoesthesia, partial seizures

Cardiovascular

Common (1% to 10%): Hypertension, peripheral edema

Gastrointestinal

Very common (10% or more): Dysphagia (up to 39%), dry mouth (up to 39%)

Common (1% to 10%): Nausea, diarrhea, constipation, vomiting, gastroenteritis

Genitourinary

Common (1% to 10%): Urinary tract infection, blood present in urine

Hepatic

Uncommon (0.1% to 1%): Abnormal liver function tests

Hypersensitivity

Rare (less than 0.1%): Anaphylaxis, urticaria, soft tissue edema

Postmarketing reports: Hypersensitivity reactions including anaphylaxis

Metabolic

Frequency not reported: Blood triglycerides increased

Ocular

Very common (10% or more): Eye disorders (e.g., vision blurred, diplopia, visual acuity reduced, eye pain, eyelid disorder, accommodation disorder, dry eye, eye pruritus) (up to 17%)

Common (1% to 10%): Eyelid edema, eyelid ptosis

Postmarketing reports: Photophobia

Local

Very common (10% or more): Injection site discomfort (e.g., pain, bruising, hemorrhage, injection site erythema/hematoma) (up to 22%)

Common (1% to 10%): Injection site pain

Respiratory

Very common (10% or more): Nasopharyngitis (10%), upper respiratory infection (10%)

Common (1% to 10%): Breathing difficulty, dyspnea, sinusitis, cough, pharyngitis, bronchitis, rhinitis, oropharyngeal pain

Musculoskeletal

Very common (10% or more): Muscular weakness (up to 56%)

Common (1% to 10%): Musculoskeletal pain, muscle atrophy, pain in extremity, back pain, wrist fracture

Uncommon (0.1% to 1%): Gait disturbance, hypertonia

Postmarketing reports: Amyotrophy

Immunologic

Common (1% to 10%): Infection, influenza, neutralizing antibodies

Dermatologic

Frequency not reported: Excessive granulation tissue, erythema

Other

Very common (10% or more): Fatigue (12%)

Common (1% to 10%): Fall, injury, contusion, ear infection, pyrexia

Uncommon (0.1% to 1%): Sensation of heaviness

Frequency not reported: Distant spread of toxin effects

Postmarketing reports: Vertigo, burning sensation, hypoesthesia

Psychiatric

Common (1% to 10%): Depression, insomnia

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Dysport (www.drugs.com/dysport.html).