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Note: This document contains side effect information about abobotulinumtoxinA. Some of the dosage forms listed on this page may not apply to the brand name Dysport.
Common side effects of Dysport include: dysphagia, headache, myasthenia, nasopharyngitis, voice disorder, and xerostomia. See below for a comprehensive list of adverse effects.
Applies to abobotulinumtoxinA: intramuscular powder for solution
Intramuscular route (Powder for Solution)
The effects of abobotulinumtoxinA and all botulinum toxin products may spread from the area of injection to produce symptoms consistent with botulinum toxin effects. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening and there have been reports of death. The risk of symptoms is probably greatest in children treated for spasticity but symptoms can also occur in adults, particularly in those patients who have underlying conditions that would predispose them to these symptoms. In unapproved uses, including upper limb spasticity in children, and in approved indications, spread of effect has reported at doses comparable to or lower than the maximum recommended total dose.
Along with its needed effects, abobotulinumtoxinA (the active ingredient contained in Dysport) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking abobotulinumtoxinA:
Incidence not known
Some side effects of abobotulinumtoxinA may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Applies to abobotulinumtoxinA: injectable powder for injection, intramuscular powder for injection
The most commonly occurring side effects have included muscular weakness, dysphagia, dry mouth, injection site pain and discomfort, fatigue, headache, and nasopharyngitis.
Very common (10% or more): Dysphonia (up to 28%), headache (11%), facial paresis (up to 11%)
Common (1% to 10%): Dizziness, convulsion, syncope, hypoesthesia, partial seizures
Common (1% to 10%): Hypertension, peripheral edema
Very common (10% or more): Dysphagia (up to 39%), dry mouth (up to 39%)
Common (1% to 10%): Nausea, diarrhea, constipation, vomiting, gastroenteritis
Common (1% to 10%): Urinary tract infection, blood present in urine
Uncommon (0.1% to 1%): Abnormal liver function tests
Rare (less than 0.1%): Anaphylaxis, urticaria, soft tissue edema
Postmarketing reports: Hypersensitivity reactions including anaphylaxis
Frequency not reported: Blood triglycerides increased
Very common (10% or more): Eye disorders (e.g., vision blurred, diplopia, visual acuity reduced, eye pain, eyelid disorder, accommodation disorder, dry eye, eye pruritus) (up to 17%)
Common (1% to 10%): Eyelid edema, eyelid ptosis
Postmarketing reports: Photophobia
Very common (10% or more): Injection site discomfort (e.g., pain, bruising, hemorrhage, injection site erythema/hematoma) (up to 22%)
Common (1% to 10%): Injection site pain
Very common (10% or more): Nasopharyngitis (10%), upper respiratory infection (10%)
Common (1% to 10%): Breathing difficulty, dyspnea, sinusitis, cough, pharyngitis, bronchitis, rhinitis, oropharyngeal pain
Very common (10% or more): Muscular weakness (up to 56%)
Common (1% to 10%): Musculoskeletal pain, muscle atrophy, pain in extremity, back pain, wrist fracture
Uncommon (0.1% to 1%): Gait disturbance, hypertonia
Postmarketing reports: Amyotrophy
Common (1% to 10%): Infection, influenza, neutralizing antibodies
Frequency not reported: Excessive granulation tissue, erythema
Very common (10% or more): Fatigue (12%)
Common (1% to 10%): Fall, injury, contusion, ear infection, pyrexia
Uncommon (0.1% to 1%): Sensation of heaviness
Frequency not reported: Distant spread of toxin effects
Postmarketing reports: Vertigo, burning sensation, hypoesthesia
Common (1% to 10%): Depression, insomnia