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Dutoprol

Generic Name: hydrochlorothiazide and metoprolol (HYE droe klor oh THYE a zide and me TOE proe lole)
Brand Name: Dutoprol
Physician reviewed Dutoprol patient information - includes Dutoprol description, dosage and directions.
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Drug Information:
HydroChlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Metoprolol is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins). Dutoprol is a combination medicine used to treat high blood pressure (hypertension). Dutoprol may also be used for purposes not listed in this medication guide. You should not use Dutoprol if you have a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker), slow heartbeats that have caused you to faint, or if your heart cannot pump blood properly. Learn more

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Dutoprol Side Effects

Note: This document contains side effect information about hydrochlorothiazide / metoprolol. Some of the dosage forms listed on this page may not apply to the brand name Dutoprol.

For the Consumer

Applies to hydrochlorothiazide / metoprolol: oral tablet

Warning

Oral route (Tablet)

Following abrupt cessation of therapy with certain beta-blocking agents, exacerbations of angina pectoris and, in some cases, myocardial infarction have been reported. Even in the absence of overt angina pectoris, when discontinuing therapy, metoprolol should not be withdrawn abruptly, and patients should be cautioned against interruption of therapy without the physician's advice.

Along with its needed effects, hydrochlorothiazide/metoprolol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / metoprolol:

More common

  • Chest pain or discomfort
  • convulsions
  • decreased urine
  • dry mouth
  • increased thirst
  • lightheadedness, dizziness, or fainting
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • slow or irregular heartbeat
  • unusual tiredness or weakness

Less common

  • Ankle, knee, or great toe joint pain
  • decreased ability to exercise
  • difficult or labored breathing
  • joint stiffness or swelling
  • lower back or side pain
  • swelling of the face, fingers, feet, or lower legs
  • tightness in the chest

Get emergency help immediately if any of the following symptoms of overdose occur while taking hydrochlorothiazide / metoprolol:

Symptoms of overdose

  • Blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chemical imbalance in the blood
  • cold, clammy skin
  • coma
  • confusion
  • cough
  • dilated neck veins
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • extreme fatigue
  • fast or pounding heartbeat or pulse
  • frequent urination
  • headache
  • increased volume of pale, dilute urine
  • irregular breathing
  • irritability
  • noisy breathing
  • not able to pass urine
  • pain or aching in the lower legs
  • pain or weakness in the hands or feet
  • seizures
  • sweating
  • trembling
  • unconsciousness
  • very drowsy or sleepy
  • weak pulse
  • weakness and heaviness of the legs
  • weight gain

Some side effects of hydrochlorothiazide / metoprolol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Chills
  • diarrhea
  • feeling of constant movement of self or surroundings
  • fever
  • general feeling of discomfort or illness
  • muscle aches
  • nightmares
  • runny nose
  • sensation of spinning
  • shivering
  • sleepiness
  • sore throat
  • trouble sleeping
  • unusual drowsiness, dullness, or feeling of sluggishness

Less common

  • Continuing ringing or buzzing or other unexplained noise in the ears
  • decreased interest in sexual intercourse
  • difficulty having a bowel movement (stool)
  • earache
  • hearing loss
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • pinpoint red or purple spots on the skin
  • weight loss

For Healthcare Professionals

Applies to hydrochlorothiazide / metoprolol: oral tablet, oral tablet extended release

General

The most common side effects were fatigue, lethargy, flu syndrome, dizziness, vertigo, drowsiness, somnolence, and headache.

Gastrointestinal

Common (1% to 10%): Diarrhea, digestive disorder, dry mouth, nausea, vomiting, constipation

Hydrochlorothiazide:

Frequency not reported: Sialadenitis, vomiting, diarrhea, cramping, nausea, gastric irritation, constipation

Metoprolol:

Common (1% to 10%): Diarrhea, nausea, gastric pain, constipation, flatulence, heartburn

Frequency not reported: Vomiting, retroperitoneal fibrosis

Postmarketing reports: Dry mouth

Nervous system

Common (1% to 10%): Lethargy, dizziness, drowsiness, somnolence, headache, tinnitus

Hydrochlorothiazide:

Frequency not reported: Dizziness, headache, paresthesia

Metoprolol:

Common (1% to 10%): Tiredness, dizziness

Frequency not reported: Short-term memory loss, headache

Postmarketing reports: Somnolence, paresthesia, syncope, taste disturbance

Other

Common (1% to 10%): Fatigue, vertigo, exercise tolerance decreased, edema, earache

Hydrochlorothiazide:

Frequency not reported: Vertigo, weakness

Postmarketing reports: Fever

Metoprolol:

Frequency not reported: Fatigue

Postmarketing reports: Lactic dehydrogenase elevation, alkaline phosphatase elevation, blood triglycerides increased, high-density lipoprotein decreased, tinnitus

Metabolic

Common (1% to 10%): Hypokalemia, gout, anorexia

Hydrochlorothiazide:

Frequency not reported: Anorexia, hyperglycemia, hyperuricemia, hypokalemia

Metoprolol:

Frequency not reported: Weight gain

Dermatologic

Common (1% to 10%): Sweating, purpura

Hydrochlorothiazide:

Frequency not reported: Stevens-Johnson syndrome, purpura, urticaria, rash, photosensitivity

Postmarketing reports: Erythema multiforme, exfoliative dermatitis, toxic epidermal necrolysis

Metoprolol:

Uncommon (0.1% to 1%): Pruritus

Frequency not reported: Gangrene, rash, photosensitivity, worsening of psoriasis, alopecia

Postmarketing reports: Sweating

Gangrene has been reported very rarely in patients with preexisting severe peripheral circulatory disorders who were taking metoprolol.

Respiratory

Common (1% to 10%): Dyspnea, nasopharyngitis

Hydrochlorothiazide:

Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema

Metoprolol:

Common (1% to 10%): Shortness of breath

Uncommon (0.1% to 1%): Wheezing

Frequency not reported: Rhinitis

Postmarketing reports: Dyspnea

Cardiovascular

Common (1% to 10%): Bradycardia

Hydrochlorothiazide:

Frequency not reported: Orthostatic hypotension, necrotizing angiitis

Metoprolol:

Common (1% to 10%): Bradycardia

Frequency not reported: Cold extremities, arterial insufficiency, palpitations, congestive heart failure

Postmarketing reports: Peripheral edema, chest pain

Ocular

Common (1% to 10%): Blurred vision

Hydrochlorothiazide:

Frequency not reported: Transient blurred vision, xanthopsia

Metoprolol:

Postmarketing reports: Blurred vision, dry eyes

Psychiatric

Common (1% to 10%): Nightmare

Hydrochlorothiazide:

Frequency not reported: Restlessness

Metoprolol:

Common (1% to 10%): Depression

Frequency not reported: Mental confusion, nightmare, insomnia

Postmarketing reports: Confusional state, anxiety/nervousness, hallucination, libido decreased

Genitourinary

Common (1% to 10%): Impotence

Hydrochlorothiazide:

Frequency not reported: Glycosuria

Metoprolol:

Very rare (less than 0.01%): Peyronie's disease

Postmarketing reports: Male impotence

Musculoskeletal

Common (1% to 10%): Muscle pain

Hydrochlorothiazide:

Frequency not reported: Muscle spasm

Metoprolol:

Frequency not reported: Arthritis

Postmarketing reports: Musculoskeletal pain, arthralgia

Immunologic

Common (1% to 10%): Flu syndrome

Hydrochlorothiazide:

Postmarketing reports: Anaphylactic reactions

Hepatic

Frequency not reported: Liver enzymes increased, serum bilirubin increased

Hydrochlorothiazide:

Frequency not reported: Pancreatitis, intrahepatic cholestatic jaundice

Metoprolol:

Postmarketing reports: Hepatitis, jaundice, non-specific hepatic dysfunction, transaminase elevation

Hematologic

Hydrochlorothiazide:

Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, hemolytic anemia

Renal

Hydrochlorothiazide:

Postmarketing reports: Interstitial nephritis

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Dutoprol (www.drugs.com/mtm/dutoprol.html).