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Droperidol

Generic Name: droperidol (dro PER i dol)
Brand Name: Inapsine
Physician reviewed droperidol patient information - includes droperidol description, dosage and directions.
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Drug Information:
DropeRidol is a sedative, tranquilizer, and anti-nausea medicine. DropeRidol is used to reduce nausea and vomiting caused by surgery or other medical procedures. DropeRidol may also be used for purposes not listed in this medication guide. You should not use dropeRidol if you have a personal or family history of long QT syndrome. Tell your caregivers at once if you have sudden dizziness with fast or pounding heartbeats, fluttering in your chest, or trouble breathing. You should not be treated with dropeRidol if you are allergic to it, or if you have a personal or family history of long QT syndrome. Learn more

Droperidol Side Effects

Droperidol Side Effects

For the Consumer

Applies to droperidol: injection solution

Warning

Injection route (Solution)

Cases of QT prolongation and/or torsade de pointes, some fatal, have been reported in patients receiving droperidol at doses at or below recommended doses. All patients should undergo a 12-lead ECG prior to administration of droperidol to determine if a prolonged QT interval (i.e., QTc greater than 440 msec for males or 450 msec for females) is present. Do not administer droperidol if there is a prolonged QT interval. Droperidol is contraindicated in patients with known or suspected QT prolongation, including patients with congenital long QT syndrome. Administer droperidol with extreme caution to patients who may be at risk for development of prolonged QT syndrome, are over 65 years old, abuse alcohol, or when used concomitantly with benzodiazepines, volatile anesthetics, and IV opiates. ECG monitoring should be performed prior to treatment and continued for 2 to 3 hours after completing treatment to monitor for arrhythmias.

Along with its needed effects, droperidol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking droperidol:

More common

  • Blurred vision
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • sweating
  • unusual tiredness or weakness

Less common

  • Chills
  • cough
  • difficulty with breathing
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • noisy breathing
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash, hives, or itching
  • tightness in the chest

Incidence not known

  • Chest pain or discomfort
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • irregular or slow heart rate
  • low blood pressure or pulse
  • severe confusion or loss of consciousness

Some side effects of droperidol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Anxiety
  • drowsiness
  • restlessness
  • trouble sitting still

Incidence not known

  • Difficulty with speaking
  • drooling
  • loss of balance control
  • muscle trembling, jerking, or stiffness
  • seeing, hearing, or feeling things that are not there
  • shuffling walk
  • stiffness of the limbs
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back

For Healthcare Professionals

Applies to droperidol: compounding powder, injectable solution

Cardiovascular

Frequency not reported: Hypotension, irregular cardiac rhythm, mild or moderate tachycardia, QT prolongation, serious arrhythmias (e.g., torsades de pointes), ventricular tachycardia, cardiac arrest, death (some of these side effects occurred in patients with no known risk factors, and some were associated with droperidol doses at or below recommended doses)

Nervous system

Unexplained fever, alteration of consciousness, extrapyramidal dysfunction, autonomic instability and elevated creatine kinase are all symptoms associated with neuroleptic agents. If these symptoms develop in patients receiving droperidol therapy, immediate discontinuation of the drug is warranted.

Extrapyramidal symptoms such as acute dystonia, parkinsonism, akathisia, and oculogyric crisis have been reported in patients receiving droperidol in doses as low as 0.65 mg. In addition, cases of akathisia have been reported in patients during epidural anesthesia.

Frequency not reported: Dysphoria, drowsiness, restlessness, hyperactivity, anxiety, hallucinations, dizziness, extrapyramidal symptoms, neuroleptic malignant syndrome, confusion, nervousness, paresthesia, somnolence, tremor, akathisia, oculogyric crisis, unexplained fever, alteration of consciousness, autonomic instability

Respiratory

Frequency not reported: pharyngitis, rhinitis, bronchospasm, laryngospasm (reported as rare)

Hypersensitivity

Frequency not reported: Anaphylaxis (uncommon)

Local

Frequency not reported : Injection site pain

Other

Frequency not reported: Chills and/or shivering, tongue-swelling, sweating

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Droperidol (www.drugs.com/mtm/droperidol.html).