USARx offers multiple ways to purchase this medication. Choose the Best option for you!
Note: This document contains side effect information about doxorubicin liposomal. Some of the dosage forms listed on this page may not apply to the brand name Doxil.
Common side effects of Doxil include: severe anemia, severe erythrodysesthesia syndrome, nausea, vomiting, diarrhea, stomatitis, erythrodysesthesia syndrome, alopecia, anemia, asthenia, bone marrow depression, neutropenia, thrombocytopenia, and anorexia. Other side effects include: asthma, syncope, severe neutropenia, back pain, chest pain, dyspnea, facial edema, fever, headache, hypotension, pruritus, skin rash, tachycardia, pharyngitis, and chills. See below for a comprehensive list of adverse effects.
Applies to doxorubicin liposomal: intravenous solution
Intravenous route (Solution)
DOXOrubicin hydrochloride (HCl) can cause myocardial damage which can lead to congestive heart failure as the total cumulative dose (including anthracyclines or anthracenediones) approaches 550 mg/m(2). Cardiac toxicity may also occur at lower cumulative doses with mediastinal irradiation or concurrent cardiotoxic agents. Serious and sometimes life-threatening or fatal infusion reactions have been reported. Symptoms may include flushing, shortness of breath, facial swelling, headache, chills, back pain, tightness in the chest or throat, or hypotension.
Along with its needed effects, doxorubicin liposomal (the active ingredient contained in Doxil) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking doxorubicin liposomal:
Some side effects of doxorubicin liposomal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Applies to doxorubicin liposomal: intravenous dispersion, intravenous powder for injection
The most common adverse reactions (occurring more than 20% of patients) are asthenia, fatigue, fever, nausea, stomatitis, vomiting, diarrhea, constipation, anorexia, hand-foot syndrome, rash and neutropenia, thrombocytopenia, and anemia.
Common (1% to 10%): Cardiovascular disorder, vasodilatation, hypotension, orthostatic hypotension, flushing, hypertension, phlebitis, ejection fraction decreased, arrhythmia, cardiomyopathy, congestive heart failure, hot flushes, tachycardia, deep vein thrombosis, cardiac arrest
Uncommon (0.1% to 1%): Venous thromboembolism (including thrombophlebitis), venous thrombosis, pericardial effusion
Very common (10% or more): Leucopenia, anemia, neutropenia, thrombocytopenia
Common (1% to 10%): Myelosuppression
Very common (10% or more): Hand-foot syndrome (51%), rash (29%), alopecia (19%), dry skin, skin discoloration, vesiculobullous rash, pruritus, exfoliative dermatitis, skin disorder, maculopapular rash, sweating, acne, skin ulcer
Common (1% to 10%): Nail disorder, ecchymosis
Uncommon (0.1% to 1%): Purpura, pruritus, folliculitis
Rare (0.01% to 0.1%): Radiation recall reaction
Very rare (less than 0.01%): Erythema multiforme, Stevens Johnson syndrome, toxic epidermal necrolysis
Very common (10% or more): Constipation, diarrhea, nausea, stomatitis, vomiting
Common (1% to 10%): Pharyngitis, abdominal pain, dyspepsia, mouth ulceration, esophagitis, gastritis, dysphagia, dry mouth, flatulence, gingivitis, taste perversion, oral candidiasis, oral moniliasis, glossitis
Uncommon (0.1% to 1%): Dyspepsia, gastric ulcer
Common (1% to 10%): Allergic reaction
Renal insufficiency has been associated with doxorubicin-induced hyperuricemia (secondary to cell lysis). Adequate hydration, diuresis, and allopurinol can be preventative.
Animal data suggest that doxorubicin may cause glomerular basement membrane injury via production of reactive oxygen species. Administration of some antioxidants, however, have failed to reduce the urinary excretion of lysozyme and N-acetyl-glucosaminidase (markers of tubule injury) in treated animals.
Common (1% to 10%): Blood creatinine increased
Very common (10% or more): Asthenia, mucous membrane disorder, pain, fever, rigors
Common (1% to 10%): Peripheral edema, chills, malaise, hyperthermia
Postmarketing reports: Secondary oral cancers (primarily squamous cell carcinoma)
Common (1% to 10%): Conjunctivitis, retinitis
Common (1% to 10%): Dysuria, vaginitis
Uncommon (0.1% to 1%): Hemorrhagic cystitis, oliguria
Very common (10% or more): Back pain (12%)
Common (1% to 10%): Myalgia
Uncommon (0.1% to 1%): Muscle weakness
Very common (10% or more): Peripheral sensory neuropathy, neuralgia, headache
Common (1% to 10%): Paresthesia, somnolence, peripheral neuropathy, paresthesia, polyneuropathy, dizziness, dysgeusia, lethargy, hypoesthesia, syncope, dysesthesia
Uncommon (0.1% to 1%): Abnormal gait, dysphonia
Common (1% to 10%): Dyspnea, cough, pneumonia, nasopharyngitis, upper respiratory tract infection, sinusitis, rhinitis
Very common (10% or more): Anorexia, weight loss
Common (1% to 10%): Dehydration, hypocalcemia
Uncommon (0.1% to 1%): Hyperglycemia
Common (1% to 10%): Aspartate aminotransferase increased, alanine aminotransferase increased
Uncommon (0.1% to 1%): Injection site infection
Very rare (less than 0.01%): Extravasation injury
Very common (10% or more): Neutropenic fever, infections
Common (1% to 10%): Herpes simplex, herpes zoster, influenza-like illness
Uncommon (0.1% to 1%): Sepsis, pneumonitis
Common (1% to 10%): Anxiety, insomnia, depression
Uncommon (0.1% to 1%): Agitation