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Doxercalciferol is a synthetic (man- made) form of vitamin D. Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body.
Doxercalciferol is used to help maintain healthy levels of parathyroid hormone in people with chronic kidney disease who are on dialysis.
Doxercalciferol may also be used for purposes not listed in this medication guide.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
You should not use doxercalciferol if you are allergic to it, or if you have high levels of vitamin D or calcium in your body.
Tell your doctor if you have ever had:
liver disease;
a vitamin D deficiency; or
high levels of calcium in your blood (hypercalcemia).
Tell your doctor if you are pregnant or breast-feeding.
If you breast-feed while receiving doxercalciferol injection, watch for signs of hypercalcemia in your baby (such as feeding problems, vomiting, constipation, or seizure).
Doxercalciferol is not approved for use by anyone younger than 18 years old.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Doxercalciferol is usually given either once daily or 3 times per week. Follow your doctor's dosing instructions very carefully.
Doxercalciferol oral is taken by mouth.
Doxercalciferol injection is given as an infusion into a vein at the end of dialysis. A healthcare provider will give you this injection.
Your blood will need to be tested often. Your doses may be delayed based on the results.
Even if you have no symptoms, tests can help your doctor determine if doxercalciferol is effective.
Store at room temperature away from moisture and heat.
Call your doctor for instructions if you miss a dose of doxercalciferol.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Avoid using any vitamin D or calcium supplements without your doctor's advice.
Get emergency medical help if you have signs of an allergic reaction: hives; chest discomfort, difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using doxercalciferol and call your doctor at once if you have:
chest pain, slow heartbeats;
high calcium levels--nausea, vomiting, constipation, increased thirst or urination, confusion, lack of energy, weight loss, tiredness;
signs of infection--fever, chills, flu-like symptoms, warmth, redness, vomiting, diarrhea, pain or burning when you urinate;
low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, cold hands and feet; or
dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin.
Common side effects may include:
numbness, tingling, burning pain;
infections, not feeling well;
cold symptoms such as stuffy nose, sneezing, cough;
itching;
headache, dizziness, weakness;
depressed mood, trouble sleeping;
upset stomach, nausea, vomiting, constipation;
feeling short of breath;
swelling; or
muscle stiffness.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Some medicines can make doxercalciferol much less effective when taken at the same time. If you take any of the following medicines, take your oral doxercalciferol dose 1 hour before or 4 to 6 hours after you take the other medicine:
cholestyramine; or
mineral oil.
Tell your doctor about all your other medicines, especially:
digoxin;
an antacid;
an antibiotic or antifungal medicine;
a calcium or a vitamin D supplement;
a diuretic or "water pill"; or
seizure medicine.
This list is not complete. Other drugs may affect doxercalciferol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Doxercalciferol (www.drugs.com/mtm/doxercalciferol-oral-injection.html).
Applies to doxercalciferol: oral capsules, parenteral injection
Side effects include:
In dialysis patients: Edema, headache, malaise, nausea/vomiting, dizziness, dyspnea, pruritus, bradycardia.
In predialysis patients with stage 3 or 4 CKD: Infection, chest pain, constipation, dyspepsia, anemia, dehydration, depression, hypertonia, insomnia, paresthesia, increased cough, dyspnea, rhinitis.
Excessive vitamin D intake (early manifestations): Weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, bone pain, metallic taste, anorexia.
Excessive vitamin D intake (late manifestations): Polyuria, polydipsia anorexia, weight loss, nocturia, calcific conjunctivitis, pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, increased BUN, albuminuria, hypercholesterolemia, increased serum AST and ALT concentrations, ectopic calcification, hypertension, cardiac arrhythmias, sensory disturbances, dehydration, apathy, growth arrest, urinary tract infections.
Applies to doxercalciferol: injectable solution, oral capsule
Early signs and symptoms of hypercalcemia have included weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, metallic taste, and anorexia.
Prolonged hypercalcemia may result in polyuria, polydipsia, anorexia, weight loss, nocturia conjunctivitis (calcific), pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated blood urea nitrogen (BUN), albuminuria, hypercholesterolemia, elevated serum aspartate transaminase (AST) and alanine transaminase (ALT), ectopic calcification, hypertension, cardiac arrhythmias, sensory disturbances, dehydration, apathy, arrested growth, urinary tract infections, and, rarely, overt psychosis.
Hyperphosphatemia may exacerbate hyperparathyroidism.
Hypercalciuria may accelerate the onset of renal failure.
Very common (10% or more): Edema (34.4%)
Common (1% to 10%): Anorexia, weight increase, dehydration
Frequency not reported: Hypercalcemia, hyperphosphatemia, hypercalciuria
Oversuppression of iPTH may result in adynamic bone syndrome.
Frequency not reported: Oversuppression of parathyroid hormone
Common (1% to 10%): Bradycardia, chest pain
Very common (10% or more): Nausea/vomiting (21.3%)
Common (1% to 10%): Dyspepsia, constipation
Common (1% to 10%): Arthralgia
Very common (10% or more): Headache (27.9%), dizziness (11.5%)
Common (1% to 10%): Hypertonia, paresthesia
Common (1% to 10%): Pruritus
Very common (10% or more): Dyspnea (11.5%)
Common (1% to 10%): Cough increased, rhinitis
Very common (10% or more): Malaise (27.9%)
Common (1% to 10%): Abscess
Common (1% to 10%): Sleep disorder, depression
Uncommon (0.1% to 1%): Insomnia
Common (1% to 10%): Infection
Hypersensitivity reactions include anaphylaxis with symptoms of angioedema (involving face, lips, tongue, and airway), hypotension, unresponsiveness, chest discomfort, shortness of breath, cardiopulmonary arrest, pruritus, and skin burning sensation. These reactions may occur separately or together.
Postmarketing reports: Hypersensitivity reactions (including fatal outcome)
Common (1% to 10%): Anemia
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Doxercalciferol (www.drugs.com/mtm/doxercalciferol-oral-injection.html).
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