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Doxercalciferol Prescription
Generic Name: doxercalciferol (oral/injection) (dock sir kal SIH fer all)
Brand Name: Hectorol
Physician reviewed doxercalciferol (oral/injection) (oral/injection) patient information - includes doxercalciferol (oral/injection) description, dosage and directions.
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Doxercalciferol Drug Information:

Doxercalciferol is a synthetic (man- made) form of Vitamin D. Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body. Doxercalciferol is used to help maintain healthy levels of paraThyroid hormone in people with chronic kidney disease who are on dialysis. Doxercalciferol may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare prOviders about all your medical conditions, allergies, and all medicines you use. Learn more

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Doxercalciferol Side Effects

For the Consumer

Applies to doxercalciferol: oral capsules, parenteral injection

Side effects include:

In dialysis patients: Edema, headache, malaise, nausea/vomiting, dizziness, dyspnea, pruritus, bradycardia.

In predialysis patients with stage 3 or 4 CKD: Infection, chest pain, constipation, dyspepsia, anemia, dehydration, depression, hypertonia, insomnia, paresthesia, increased cough, dyspnea, rhinitis.

Excessive vitamin D intake (early manifestations): Weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, bone pain, metallic taste, anorexia.

Excessive vitamin D intake (late manifestations): Polyuria, polydipsia anorexia, weight loss, nocturia, calcific conjunctivitis, pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, increased BUN, albuminuria, hypercholesterolemia, increased serum AST and ALT concentrations, ectopic calcification, hypertension, cardiac arrhythmias, sensory disturbances, dehydration, apathy, growth arrest, urinary tract infections.

For Healthcare Professionals

Applies to doxercalciferol: injectable solution, oral capsule


Early signs and symptoms of hypercalcemia have included weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, metallic taste, and anorexia.

Prolonged hypercalcemia may result in polyuria, polydipsia, anorexia, weight loss, nocturia conjunctivitis (calcific), pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated blood urea nitrogen (BUN), albuminuria, hypercholesterolemia, elevated serum aspartate transaminase (AST) and alanine transaminase (ALT), ectopic calcification, hypertension, cardiac arrhythmias, sensory disturbances, dehydration, apathy, arrested growth, urinary tract infections, and, rarely, overt psychosis.

Hyperphosphatemia may exacerbate hyperparathyroidism.

Hypercalciuria may accelerate the onset of renal failure.

Very common (10% or more): Edema (34.4%)

Common (1% to 10%): Anorexia, weight increase, dehydration

Frequency not reported: Hypercalcemia, hyperphosphatemia, hypercalciuria


Oversuppression of iPTH may result in adynamic bone syndrome.

Frequency not reported: Oversuppression of parathyroid hormone


Common (1% to 10%): Bradycardia, chest pain


Very common (10% or more): Nausea/vomiting (21.3%)

Common (1% to 10%): Dyspepsia, constipation


Common (1% to 10%): Arthralgia

Nervous system

Very common (10% or more): Headache (27.9%), dizziness (11.5%)

Common (1% to 10%): Hypertonia, paresthesia


Common (1% to 10%): Pruritus


Very common (10% or more): Dyspnea (11.5%)

Common (1% to 10%): Cough increased, rhinitis


Very common (10% or more): Malaise (27.9%)

Common (1% to 10%): Abscess


Common (1% to 10%): Sleep disorder, depression

Uncommon (0.1% to 1%): Insomnia


Common (1% to 10%): Infection


Hypersensitivity reactions include anaphylaxis with symptoms of angioedema (involving face, lips, tongue, and airway), hypotension, unresponsiveness, chest discomfort, shortness of breath, cardiopulmonary arrest, pruritus, and skin burning sensation. These reactions may occur separately or together.

Postmarketing reports: Hypersensitivity reactions (including fatal outcome)


Common (1% to 10%): Anemia

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Doxercalciferol (www.drugs.com/mtm/doxercalciferol-oral-injection.html).