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Applies to doxercalciferol: oral capsules, parenteral injection
Side effects include:
In dialysis patients: Edema, headache, malaise, nausea/vomiting, dizziness, dyspnea, pruritus, bradycardia.
In predialysis patients with stage 3 or 4 CKD: Infection, chest pain, constipation, dyspepsia, anemia, dehydration, depression, hypertonia, insomnia, paresthesia, increased cough, dyspnea, rhinitis.
Excessive vitamin D intake (early manifestations): Weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, bone pain, metallic taste, anorexia.
Excessive vitamin D intake (late manifestations): Polyuria, polydipsia anorexia, weight loss, nocturia, calcific conjunctivitis, pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, increased BUN, albuminuria, hypercholesterolemia, increased serum AST and ALT concentrations, ectopic calcification, hypertension, cardiac arrhythmias, sensory disturbances, dehydration, apathy, growth arrest, urinary tract infections.For Healthcare Professionals
Applies to doxercalciferol: injectable solution, oral capsuleMetabolic
Early signs and symptoms of hypercalcemia have included weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, metallic taste, and anorexia.
Prolonged hypercalcemia may result in polyuria, polydipsia, anorexia, weight loss, nocturia conjunctivitis (calcific), pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated blood urea nitrogen (BUN), albuminuria, hypercholesterolemia, elevated serum aspartate transaminase (AST) and alanine transaminase (ALT), ectopic calcification, hypertension, cardiac arrhythmias, sensory disturbances, dehydration, apathy, arrested growth, urinary tract infections, and, rarely, overt psychosis.
Hyperphosphatemia may exacerbate hyperparathyroidism.
Hypercalciuria may accelerate the onset of renal failure.
Very common (10% or more): Edema (34.4%)
Common (1% to 10%): Anorexia, weight increase, dehydration
Frequency not reported: Hypercalcemia, hyperphosphatemia, hypercalciuriaEndocrine
Oversuppression of iPTH may result in adynamic bone syndrome.
Frequency not reported: Oversuppression of parathyroid hormoneCardiovascular
Common (1% to 10%): Bradycardia, chest painGastrointestinal
Very common (10% or more): Nausea/vomiting (21.3%)
Common (1% to 10%): Dyspepsia, constipationMusculoskeletal
Common (1% to 10%): ArthralgiaNervous system
Very common (10% or more): Headache (27.9%), dizziness (11.5%)
Common (1% to 10%): Hypertonia, paresthesiaDermatologic
Common (1% to 10%): PruritusRespiratory
Very common (10% or more): Dyspnea (11.5%)
Common (1% to 10%): Cough increased, rhinitisOther
Very common (10% or more): Malaise (27.9%)
Common (1% to 10%): AbscessPsychiatric
Common (1% to 10%): Sleep disorder, depression
Uncommon (0.1% to 1%): InsomniaImmunologic
Common (1% to 10%): InfectionHypersensitivity
Hypersensitivity reactions include anaphylaxis with symptoms of angioedema (involving face, lips, tongue, and airway), hypotension, unresponsiveness, chest discomfort, shortness of breath, cardiopulmonary arrest, pruritus, and skin burning sensation. These reactions may occur separately or together.
Postmarketing reports: Hypersensitivity reactions (including fatal outcome)Hematologic
Common (1% to 10%): Anemia
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.
Source: Drugs.com Doxercalciferol (www.drugs.com/mtm/doxercalciferol-oral-injection.html).
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