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Doxazosin Prescription
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Generic Name: doxazosin (dox AY zo sin)
Brand Names: Cardura, Cardura XL, Doxadura, Cascor, Carduran
Doxazosin is used to treat hypertension (high blood pressure) and benign prostatic hyperplasia (enlarged prostate). Learn about side effects, interactions and indications.
Generic Name: doxazosin (dox AY zo sin)
Brand Names: Cardura, Cardura XL, Doxadura, Cascor, Carduran
Doxazosin is used to treat hypertension (high blood pressure) and benign prostatic hyperplasia (enlarged prostate). Learn about side effects, interactions and indications.
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30 tablets of Doxazosin 40 mg
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Doxazosin Drug Information:

Doxazosin is an alpha-adrenergic (AL-fa ad-ren-ER-jik) blockers. It relaxes your veins and arteries so that blood can more easily pass through them. It also relaxes the muscles in the prostate and bladder neck, making it easier to urinate. Doxazosin is used to treat hypertension (high blood pressure), or to improve urination in men with benign prostatic hyperplasia (enlarged prostate). The extended-release form of doxazosin (Cardura XL) is for use only in treating benign prostatic hyperplasia and should not be used to treat hypertension. Learn more

Doxazosin Side Effects

In Summary

Commonly reported side effects of doxazosin include: dizziness, fatigue, vertigo, hypertension, symptomatic orthostatic hypotension, malaise, and orthostatic hypotension due to drug. Other side effects include: syncope, drowsiness, and edema. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to doxazosin: oral tablet, oral tablet extended release

Along with its needed effects, doxazosin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking doxazosin:

More common

  • Dizziness or lightheadedness

Less common

  • Blurred vision
  • confusion
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
  • fainting (sudden)
  • fast and pounding heartbeat
  • irregular heartbeat
  • shortness of breath
  • sweating
  • swelling of feet or lower legs


  • Painful or prolonged erection of the penis (called priapism), although extremely rare, must have immediate medical attention. If painful or prolonged erection occurs, call your doctor or go to an emergency room as soon as possible

Incidence not known

  • Abdominal or stomach pain
  • area rash
  • black, tarry stools
  • bleeding gums
  • blood in urine or stools
  • chest pain or discomfort
  • chills
  • clay-colored stools
  • cough
  • dark urine
  • diarrhea
  • difficulty breathing
  • difficult, burning, or painful urination
  • fever
  • general tiredness and weakness
  • headache, sudden and severe
  • inability to speak
  • itching
  • lab results that show problems with liver
  • light-colored stools
  • loss of appetite
  • noisy breathing
  • pain or discomfort in arms, jaw, back or neck
  • pinpoint red or purple spots on skin
  • rash
  • seizures
  • slow or irregular heartbeat
  • slurred speech
  • sore throat
  • sores, ulcers, or white spots on lips or in mouth
  • swollen glands
  • temporary blindness
  • tightness in chest
  • unpleasant breath odor
  • unusual bleeding or bruising
  • upper right abdominal pain
  • vomiting
  • vomiting of blood
  • weakness in arm and/or leg on one side of the body, sudden and severe
  • wheezing
  • yellow eyes and skin

Some side effects of doxazosin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Headache
  • lack or loss of strength
  • unusual tiredness or weakness

Less common

  • Acid or sour stomach
  • back pain
  • belching
  • bladder pain
  • cloudy urine
  • difficulty in moving
  • frequent urge to urinate
  • heartburn
  • indigestion
  • joint pain
  • lower back or side pain
  • muscle aching, cramping, or weakness
  • muscle pains or stiffness
  • nausea
  • nervousness, restlessness, unusual irritability
  • runny nose
  • sleepiness or drowsiness
  • sneezing
  • sore throat
  • stomach discomfort, upset or pain
  • swollen joints

Incidence not known

  • Anxiety
  • burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feeling
  • change in frequency or urination
  • dry mouth
  • feeling of warmth
  • frequent urination
  • general feeling of discomfort or illness
  • hair loss
  • hives or welts
  • hyperventilation
  • increased urge to urinate during the night
  • increased volume of pale dilute urine
  • loss of appetite
  • painful urination
  • redness of skin
  • redness of the face, neck, arms and occasionally upper chest
  • shaking
  • swelling of the breasts or breast soreness in both females and males
  • thinning of hair
  • trouble in holding or releasing urine
  • trouble sleeping
  • waking to urinate at night
  • weight loss

For Healthcare Professionals

Applies to doxazosin: oral tablet, oral tablet extended release


The most common adverse reaction was dizziness.

Nervous system

Very common (10% or more): Dizziness (up to 19%)

Common (1% to 10%): Somnolence, headache, vertigo

Uncommon (0.1% to 1%): Cerebrovascular accident, hypoesthesia, syncope, tremor, tinnitus

Very rare (less than 0.01%): Dizziness postural, paresthesia

Frequency not reported: Taste disturbance


Very common (10% or more): Fatigue/malaise (12%)

Common (1% to 10%): Asthenia, chest pain, influenza-like symptoms

Uncommon (0.1% to 1%): Pain, facial edema


Common (1% to 10%): Dyspnea, rhinitis, respiratory tract infection, bronchitis, cough

Uncommon (0.1% to 1%): Epistaxis

Very rare (less than 0.01%): Bronchospasm

Postmarketing reports: Bronchospasm aggravated


Common (1% to 10%): Dry mouth, abdominal pain, dyspepsia, nausea

Uncommon (0.1% to 1%): Constipation, flatulence, vomiting, gastroenteritis, diarrhea

Frequency not reported: Gastrointestinal obstruction


Common (1% to 10%): Polyuria, urinary tract infection, cystitis, urinary incontinence

Uncommon (0.1% to 1%): Dysuria, micturition frequency, hematuria, impotence

Very rare (less than 0.01%): Micturition disorder, nocturia, priapism

Frequency not reported: Retrograde ejaculation


Common (1% to 10%): Hypotension, postural hypotension, palpitation, tachycardia

Uncommon (0.1% to 1%): Angina pectoris, myocardial infarction

Very rare (less than 0.01%): Bradycardia, cardiac arrhythmias, hot flushes


Common (1% to 10%): Edema, peripheral edema

Uncommon (0.1% to 1%): Gout, appetite increased, anorexia, weight increased


Common (1% to 10%): Myalgia, back pain

Uncommon (0.1% to 1%): Arthralgia

Rare (less than 0.1%): Muscle cramps, muscle weakness


Common (1% to 10%): Pruritus

Uncommon (0.1% to 1%): Skin rash

Very rare (less than 0.01%): Urticaria, purpura, alopecia


Uncommon (0.1% to 1%): Agitation, depression, anxiety, insomnia, nervousness

Frequency not reported: Libido decreased


Uncommon (0.1% to 1%): Abnormal liver function tests

Very rare (less than 0.01%): Cholestasis, hepatitis, jaundice

Postmarketing reports: Hepatitis cholestatic


Uncommon (0.1% to 1%): Allergic drug reaction

Postmarketing reports: Allergic reaction


Very rare (less than 0.01%): Leukopenia, thrombocytopenia

Frequency not reported: White blood cell counts decreased, neutrophil count decreased


Very rare (less than 0.01%): Blurred vision

Frequency not reported: Intraoperative Floppy Iris Syndrome (IFIS)


Very rare (less than 0.01%): Gynecomastia


Very rare (less than 0.01%): Diuresis increased

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.

Source: Drugs.com Doxazosin (www.drugs.com/doxazosin.html).