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Donepezil Hydrochloride

Donepezil hydrochloride Prescription
Generic Name: donepezil (oral) (doe NEP e zil)
Brand Name: Aricept, Aricept ODT
Physician reviewed donepezil (oral) patient information - includes donepezil description, dosage and directions.

Average Savings for donepezil hydrochloride (generic): 75.36%
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Donepezil Hydrochloride Drug Information:

Donepezil is used to help improve mental function in people with Alzheimer's disease. Donepezil does not work the same in all people. Some people taking donepezil have improved mental function, while others may have unchanged or even worsening mental function. Donepezil is not a cure for Alzheimer's disease. This condition will progress over time, even in people who take donepezil. Donepezil may also be used for other purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare prOviders about all your medical conditions, allergies, and all medicines you use. Learn more

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Donepezil Hydrochloride Side Effects

In Summary

Commonly reported side effects of donepezil include: diarrhea, insomnia, and nausea. Other side effects include: fatigue, muscle cramps, vomiting, weight loss, anorexia, and ecchymoses. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to donepezil: oral tablet, oral tablet disintegrating

Side effects requiring immediate medical attention

Along with its needed effects, donepezil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking donepezil:

More common

  • Diarrhea
  • loss of appetite
  • muscle cramps
  • nausea
  • trouble in sleeping
  • unusual tiredness or weakness
  • vomiting

Less common

  • Abnormal dreams
  • constipation
  • dizziness
  • drowsiness
  • fainting
  • frequent urination
  • headache
  • joint pain, stiffness, or swelling
  • mental depression
  • pain
  • unusual bleeding or bruising
  • weight loss

Rare

  • Black, tarry stools
  • bloating
  • bloody or cloudy urine
  • blurred vision
  • burning, prickling, or tingling sensations
  • cataract
  • chills
  • clumsiness or unsteadiness
  • confusion
  • cough
  • decreased urination
  • difficult or painful urination
  • dryness of mouth
  • eye irritation
  • fever
  • flushing of skin
  • frequent urge to urinate
  • high or low blood pressure
  • hives
  • hot flashes
  • increase in sexual desire or performance
  • increased heart rate and breathing
  • increased sweating
  • increased urge to urinate during the night
  • irregular heartbeat
  • itching
  • loss of bladder control
  • loss of bowel control
  • mood or mental changes, including abnormal crying, aggression, agitation, delusions, irritability, nervousness, or restlessness
  • nasal congestion
  • pain in chest, upper stomach, or throat
  • problems with speech
  • runny nose
  • severe thirst
  • shortness of breath
  • sneezing
  • sore throat
  • sunken eyes
  • tightness in chest
  • tremor
  • troubled breathing
  • wheezing
  • wrinkled skin

Incidence not known

  • Back, leg, or stomach pains
  • bleeding gums
  • chest pain or discomfort
  • coma
  • convulsions
  • dark urine
  • difficulty breathing
  • fast or irregular heartbeat
  • fatigue
  • general body swelling
  • general tiredness and weakness
  • high fever
  • increased thirst
  • indigestion
  • light-colored stools
  • muscle pain or cramps
  • nausea and vomiting
  • nosebleeds
  • pains in stomach, side, or abdomen, possibly radiating to the back
  • pale skin
  • rash
  • seeing, hearing, or feeling things that are not there
  • seizures
  • severe muscle stiffness
  • severe nausea
  • slow or irregular heartbeat
  • stomach pain
  • sweating
  • swelling of face, ankles, or hands
  • tiredness
  • unusually pale skin
  • upper right abdominal or stomach pain
  • yellow eyes and skin

Symptoms of overdose

  • Convulsions (seizures)
  • increased sweating
  • increased watering of mouth
  • increasing muscle weakness
  • low blood pressure
  • severe nausea
  • severe vomiting
  • slow heartbeat
  • troubled breathing

For Healthcare Professionals

Applies to donepezil: oral tablet, oral tablet disintegrating

General

Frequency of common adverse effects may be influenced by the rate of titration.

The most common adverse events were diarrhea, muscle cramps, fatigue, nausea, vomiting, anorexia and insomnia. Most adverse events are mild in severity and transient in nature.

Gastrointestinal

Very common (10% or more): Diarrhea, nausea

Common (1% to 10%): Vomiting, abdominal disturbance, tooth ache, fecal incontinence, gastrointestinal bleeding, bloating, epigastric pain

Uncommon (0.1% to 1%): Gastrointestinal hemorrhage, gastric and duodenal ulcers, eructation, gingivitis, flatulence, periodontal abscess, cholelithiasis, drooling, dry mouth, fever sore, gastritis, irritable colon, tongue edema, epigastric distress, gastroenteritis, increased transaminases, hemorrhoids, ileus, increased thirst, jaundice, melena, polydipsia, duodenal ulcer, stomach ulcer, hernia hiatal

Nervous system

Very common (10% or more): Headache

Common (1% to 10%): Dizziness, insomnia, somnolence, tremor, paresthesia, ataxia, nervousness, aphasia

Uncommon (0.1% to 1%): Seizure, bad taste, cerebrovascular accident, intracranial hemorrhage, transient ischemic attack, neuralgia, muscle spasm, dysphoria, gait abnormality, hypertonia, hypokinesia, neurodermatitis, numbness (localized), dysarthria, dysphasia, nystagmus, pacing

Rare (less than 0.1%): Extrapyramidal symptoms

Very rare (less than 0.01%): Neuroleptic malignant syndrome

Cardiovascular

Common (1% to 10%): Hypertension, hemorrhage, syncope, vasodilation, atrial fibrillation, hot flashes, hypotension

Uncommon (0.1% to 1%): Bradycardia, angina pectoris, postural hypotension, myocardial infarction, AV block (first degree), congestive heart failure, arteritis, peripheral vascular disease, supraventricular tachycardia, deep vein thrombosis.

Rare (less than 0.1%): SA block, AV block

Dermatologic

Common (1% to 10%): Eczema rash, pruritus, ecchymosis, diaphoresis, urticaria

Uncommon (0.1% to 1%): Dermatitis, erythema, skin discoloration, hyperkeratosis, alopecia, fungal dermatitis, hirsutism, skin striae, night sweats, skin ulcer

Genitourinary

Common (1% to 10%): Urinary incontinence, nocturia

Uncommon (0.1% to 1%): Dysuria, hematuria, urinary urgency, metrorrhagia, cystitis, enuresis, prostate hypertrophy, pyelonephritis, inability to empty bladder, breast fibroadenosis, fibrocystic breast, mastitis, pyuria, renal failure, vaginitis

Metabolic

Common (1% to 10%): Anorexia, decreased weight, dehydration

Uncommon (0.1% to 1%): Increased appetite, gout, hypokalemia, hyperglycemia, increased lactate dehydrogenase

Musculoskeletal

Common (1% to 10%): Muscle cramps, arthritis, bone fracture

Uncommon (0.1% to 1%): Muscle weakness, muscle fasciculation

Ocular

Common (1% to 10%): Cataract, eye irritation, vision blurred

Uncommon (0.1% to 1%): Dry eyes, glaucoma, blepharitis, retinal hemorrhage, conjunctival hemorrhage, spots before eyes, periorbital edema

Other

Common (1% to 10%): Fatigue, pain, accidental overdose, vertigo, abnormal crying

Uncommon (0.1% to 1%): Minor increase in serum concentration of muscle creatine kinase, diverticulitis, earache, tinnitus, decreased hearing, otitis externa, otitis media, ear buzzing, motion sickness, herpes zoster, coldness (localized), fever, edema face, abscess, cellulitis, chills, generalized coldness, head fullness

Psychiatric

Common (1% to 10%): Hallucinations, agitation, aggressive behavior, abnormal dreams, nightmares, delusions, irritability, aggression, increased libido, restlessness

Uncommon (0.1% to 1%): Emotional lability, paranoia, hostility, decreased libido, melancholia, emotional withdrawal, listlessness

Respiratory

Common (1% to 10%): Common cold, influenza, chest pain, dyspnea, sore throat, bronchitis

Uncommon (0.1% to 1%): Epistaxis, post nasal drip, pneumonia, hyperventilation, pulmonary congestion, wheezing, hypoxia, pharyngitis, pleurisy, pulmonary collapse, sleep apnea, snoring

Endocrine

Uncommon (0.1% to 1%): Diabetes mellitus, goiter

Hematologic

Uncommon (0.1% to 1%): Anemia, thrombocythemia, thrombocytopenia, eosinophilia, erythrocytopenia

Hepatic

Rare (less than 0.1%): Liver dysfunction (including hepatitis)

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Donepezil Hydrochloride (www.drugs.com/mtm/donepezil.html).