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Dofetilide Prescription
Generic Name: dofetilide (doe FET i lide)
Brand Name: Tikosyn
Physician reviewed dofetilide patient information - includes dofetilide description, dosage and directions.
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Dofetilide Drug Information:

Dofetilide is a heart rhythm medicine, also called an antiarrhythmic. Dofetilide is used to help keep the heart beating normally in people with certain heart rhythm disorders of the atrium (the upper chambers of the heart that allow blood to flow into the heart). Dofetilide is used in people with atrial fibrillation or atrial flutter. Dofetilide may also be used for purposes not listed in this medication guide. You should not take dofetilide if you have severe kidney disease or a history of Long QT syndrome. Learn more

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Dofetilide Side Effects

In Summary

Commonly reported side effects of dofetilide include: ventricular arrhythmia, ventricular tachycardia, and chest pain. Other side effects include: flu-like symptoms. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dofetilide: oral capsule


Oral route (Capsule)

To minimize the risk of induced arrhythmia, patients initiated or re-initiated on dofetilide should be placed for a minimum of 3 days in a facility that can provide calculations of creatinine clearance, continuous ECG monitoring, and cardiac resuscitation.

Along with its needed effects, dofetilide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dofetilide:

More common

  • Dizziness
  • fainting
  • fast heartbeat

Less common

  • Chest pain
  • confusion
  • facial or flaccid paralysis
  • numbness or tingling of the hands, feet, or face
  • paralysis
  • pounding, slow heartbeat
  • slurred speech
  • swelling of the ankles, arms, face, feet, fingers, legs, lips, tongue, or throat
  • troubled breathing
  • unexplained shortness of breath
  • unusual tiredness or weakness
  • weight gain
  • yellow eyes or skin

Some side effects of dofetilide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Abdominal or stomach pain
  • accidental injury
  • back pain
  • chills
  • cough
  • diarrhea
  • fever
  • flu-like symptoms
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • migraine
  • muscle aches and pains
  • nausea
  • rash
  • runny nose
  • shivering
  • sneezing
  • sore throat
  • sweating
  • trouble sleeping
  • vomiting

For Healthcare Professionals

Applies to dofetilide: oral capsule


The most frequent adverse events were headache, chest pain, and dizziness.


Very common (10% or more): Ventricular arrhythmias (up to 14.5%), ventricular tachycardia (up to 12.4%)

Common (1% to 10%): Torsade de pointes, ventricular fibrillation, atrioventricular block, heart block

Uncommon (0.1% to 1%): Bundle branch block

Frequency not reported: Angina pectoris, atrial fibrillation, hypertension, palpitation, supraventricular tachycardia, bradycardia, heart arrest, myocardial infarct

Nervous system

Very common (10% or more): Headache (11%)

Common (1% to 10%): Dizziness

Frequency not reported: Cerebral ischemia, cerebrovascular accident, facial paralysis, flaccid paralysis, migraine, paralysis, paresthesia, syncope


Very common (10% or more): Chest pain (10%)

Common (1% to 10%): Accidental injury, medical/surgical/health service procedure

Frequency not reported: Asthenia, pain, edema, peripheral edema, sudden death, application complication, injection complication, incision complication, insertion complication, device complication


Common (1% to 10%): Respiratory tract infection, dyspnea, flu syndrome

Frequency not reported: Cough increased


Common (1% to 10%): Nausea, diarrhea, abdominal pain


Common (1% to 10%): Rash

Frequency not reported: Sweating, angioedema


Common (1% to 10%): Back pain

Frequency not reported: Arthralgia


Common (1% to 10%): Insomnia

Frequency not reported: Anxiety


Frequency not reported: Urinary tract infection


Frequency not reported: Liver damage

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Dofetilide (www.drugs.com/mtm/dofetilide.html).