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Diprivan (propofol) slows the activity of your brain and nervous system.
Diprivan is used to help you relax before and during general anesthesia for surgery or other medical procedures.
Diprivan is also used to sedate a patient who is under critical care and needs a mechanical ventilator (breathing machine).
Before you receive Diprivan, tell your doctor about all your medical conditions and allergies. Also make sure your doctor knows if you are pregnant or breast-feeding. In some cases, you may not be able to use Diprivan.
You should not receive Diprivan if you are allergic to propofol.
To make sure Diprivan is safe for you, tell your doctor if you have:
epilepsy or other seizure disorder; or
high cholesterol or triglycerides (a type of fat in the blood).
Anesthesia medicine may affect brain development in a child under 3, or an unborn baby whose mother receives this medicine during late pregnancy. These effects may be more likely when the anesthesia is used for 3 hours or longer, or used for repeated procedures. Effects on brain development could cause learning or behavior problems later in life.
Negative brain effects from anesthesia have been seen in animal studies. However, studies in human children receiving single short uses of anesthesia have not shown a likely effect on behavior or learning. More research is needed.
In some cases, your doctor may decide to postpone a surgery or procedure based on these risks. Treatment may not be delayed in the case of life-threatening conditions, medical emergencies, or surgery needed to correct certain birth defects.
Ask your doctor for information about all medicines that will be used during your surgery or procedure. Also ask how long the procedure will last.
Propofol can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
Diprivan is injected into a vein through an IV. A healthcare provider will give you this injection.
You will relax and fall asleep very quickly after Diprivan is injected.
Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely while you are under the effects of Diprivan.
Since Diprivan is given by a healthcare professional in a medical setting, you are not likely to miss a dose.
Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
Diprivan can cause severe drowsiness or dizziness, which may last for several hours. You will need someone to drive you home after your surgery or procedure. Do not drive yourself or do anything that requires you to be awake and alert for at least 24 hours after you have been treated with Diprivan.
Get emergency medical help if you have any signs of an allergic reaction to Diprivan: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregiver right away if you have:
a light-headed feeling (like you might pass out) even after feeling awake;
weak or shallow breathing; or
severe pain or discomfort where the injection is given.
Common Diprivan side effects may include:
mild itching or rash;
fast or slow heart rate; or
slight burning or stinging around the IV needle.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Anesthesia:
Less than 55 years: Anesthetic Induction: 40 mg IV every 10 seconds until induction onset. Total dose required is 2 to 2.5 mg/kg with a maximum of 250 mg.
Less than 55 years: Maintenance of Anesthesia: IV infusion: 100 to 200 mcg/kg/min. Maximum dose 20,000 mcg/min. Maximum dose 10,000 mcg/min.
Intermittent bolus: 20 to 50 mg as needed.
Cardiac Anesthesia: Induction: 20 mg every 10 seconds until induction onset (0.5 to 1.5 mg/kg).
Maintenance: Opioids are generally combined with Diprivan for maintenance of anesthesia.
100 to 150 mcg/kg/min (primary propofol)
50 to 100 mcg/kg/min (secondary propofol).
Maximum dose of 15,000 mcg/min.
Neurosurgery: Induction: 20 mg every 10 seconds until induction onset (1 to 2 mg/kg).
Maintenance: 100 to 200 mcg/kg/min with a maximum dose of 20,000 mcg/min.
Intermittent IV bolus doses of 0.3 to 0.7 mg/kg mg may be given for maintenance of anesthesia while on nitrous oxide.
ICU Sedation: Initial Continuous IV: 5 mcg/kg/min for intubated mechanically ventilated patients.
Maintenance Continuous IV: May increase in 5 to 10 mcg/kg/min increments every 5 minutes until the desired level of sedation is achieved. Typical maintenance range is 5 to 50 mcg/kg/min.
Bolus administration of 10 to 20 mg should only be used to rapidly increase depth of sedation in patients where hypotension is not likely to occur.
MAC sedation: Initial Continuous IV: 100 to 150 mcg/kg/min for 3 to 5 minutes or
Slow IV: 0.5 mg/kg over 3 to 5 minutes followed by:
Maintenance IV infusion: 25 to 75 mcg/kg/min (preferred) or
incremental bolus doses of 10 to 20 mg.
Usual Geriatric Dose for Anesthesia:
Elderly, debilitated, or ASA III/IV patients.
Induction: 20 mg every 10 seconds until induction onset (1-1.5 mg/kg). Maximum dose 200 mg
Maintenance: 50-100 mcg/kg/min.
MAC sedation: The maintenance dose is usually 80% of the usual adult dose.
Usual Pediatric Dose for Anesthesia:
3 years to 16 years: Induction: 2.5 to 3.5 mg/kg over 20 to 30 seconds.
Maintenance: 125 to 300 mcg/kg/min.
Taking other medicines that make you sleepy or slow your breathing can worsen these effects. After you have been treated with Diprivan, ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.
Other drugs may interact with propofol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Diprivan (www.drugs.com/diprivan.html).
Note: This document contains side effect information about propofol. Some of the dosage forms listed on this page may not apply to the brand name Diprivan.
Applies to propofol: parenteral injectable emulsion
Side effects include:
Use for anesthesia or MAC sedation: Bradycardia, arrhythmia, tachycardia, hypotension, hypertension, movement, burning/stinging, pain at injection site, apnea, rash, pruritus.
Use for critical care setting sedation: Bradycardia, decreased cardiac output, hypotension, hyperlipidemia, respiratory acidosis (during weaning).
Applies to propofol: intravenous emulsion
Very common (10% or more): Hypotension (75%)
Common (1% to 10%): Hypertension, bradycardia
Uncommon (0.1% to 1%): Arrhythmias, atrial fibrillation, atrioventricular heart block, bigeminy, bundle branch block, cardiac arrest, ECG abnormal, edema, extrasystole, heart block, myocardial infarction, myocardial ischemia, premature ventricular contractions, ST segment depression, supraventricular tachycardia, tachycardia, ventricular fibrillation, extrasystole, syncope, chest pain, right heart failure
Rare (0.01% to 0.1%): Pulmonary edema, asystole, syncope, perioperative arrhythmias, cardiac arrest
Very rare (less than 0.01%): Cardiac failure
Frequency not reported: Cardiac arrhythmia
Very common (10% or more): Pruritus (28%)
Common (1% to 10%): Transient flush, rash
Uncommon (0.1% to 1%): Conjunctival hyperemia, diaphoresis, urticaria
Common (1% to 10%): Nausea, vomiting
Uncommon (0.1% to 1%): Hypersalivation, cramping, diarrhea, dry mouth, enlarged parotid, nausea, impaired swallowing, vomiting, ileus
Very rare (less than 0.01%): Pancreatitis, abdominal cramps
Uncommon (0.1% to 1%): Urinary retention oliguria
Rare (Less than 0.1%): Discoloration of the urine following prolonged use
Frequency not reported: Hepatomegaly
Rare (0.01% to 0.1%): Anaphylaxis, in some cases with angioedema, bronchospasm, erythema, and hypotension (these reactions have been reported to respond to adrenaline)
Common (1% to 10%): Pain during injection (e.g., burning, tingling/slinging)
Very rare (less than 0.01%): Tissue necrosis following accidental extravascular administration
Uncommon (0.1% to 1%): Hives/itching, phlebitis, redness/discoloration
Uncommon (0.1% to 1%): BUN Increased, creatinine increased, dehydration, hyperglycemia, metabolic acidosis, osmolality increased
Very rare (less than 0.01%): Metabolic acidosis, hyperkalemia, hyperlipidemia
Uncommon (0.1% to 1%): Pain in extremities, trunk pain, whole body weakness, pain in extremities, neck rigidity/stiffness
Very rare (less than 0.01%): Rhabdomyolysis (when administered at doses greater than 4 mg/kg/hour for ICU sedation)
Paresthesias (including burning, tingling, stinging) and/or pruritus, usually manifested in the perineal region, were the most frequently recorded adverse reactions in clinical trials. Paresthesias and pruritus generally occurred within 5 minutes after administration of the initial dose and were generally transient and mild to moderate in intensity. The pharmacologic basis of these sensory phenomena is unknown. No pretreatments, including the use of nonsteroidal anti-inflammatory drugs, opioids, or lidocaine, are known to have an effect on or to reduce the incidence of these sensations.
Very common (10% or more): Paresthesia (74%), excitation phenomena such as involuntary movements, twitches, tremors, hypertonus, hiccup
Common (1% to 10%): Headache, shivering
Rare (0.01% to 0.1%): Convulsions and seizures of the epileptic type
Very rare (less than 0.01%): Postoperative unconsciousness
Frequency not reported: Involuntary movements
Very common (10% or more): Hypoxemia (11%)
Common (1% to 10%): Procedural pain (bronchoscopy), transient apnea, cough, respiratory acidosis during weaning
Uncommon (0.1% to 1%): Bronchospasm, burning in throat, cough, dyspnea, hiccough, hyperventilation, hypoventilation, hypoxia, laryngospasm, pharyngitis, sneezing, tachypnea, upper airway obstruction, apnea
Very rare (less than 0.01%): Pulmonary edema
Very rare (less than 0.01%): Renal failure
Common (1% to 10%): Thrombosis, phlebitis
Uncommon (0.1% to 1%): Hemorrhage, coagulation disorder, leukocytosis
Uncommon (0.1% to 1%): Sepsis
Uncommon (0.1% to 1%): Diplopia, eye pain, nystagmus
Common (1% to 10%): Elation/euphoria
Frequency not reported: Drug abuse and dependence
Uncommon (0.1% to 1%): Fever, anticholinergic syndrome, ear pain, taste perversion, tinnitus
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Diprivan (www.drugs.com/diprivan.html).
March 28, 2020
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