Diprivan

Note: This document contains side effect information about propofol. Some of the dosage forms listed on this page may not apply to the brand name Diprivan.

Applies to propofol: parenteral injectable emulsion

Side effects include:

Use for anesthesia or MAC sedation: Bradycardia, arrhythmia, tachycardia, hypotension, hypertension, movement, burning/stinging, pain at injection site, apnea, rash, pruritus.

Use for critical care setting sedation: Bradycardia, decreased cardiac output, hypotension, hyperlipidemia, respiratory acidosis (during weaning).

Applies to propofol: intravenous emulsion

Very common (10% or more): Hypotension (75%)

Common (1% to 10%): Hypertension, bradycardia

Uncommon (0.1% to 1%): Arrhythmias, atrial fibrillation, atrioventricular heart block, bigeminy, bundle branch block, cardiac arrest, ECG abnormal, edema, extrasystole, heart block, myocardial infarction, myocardial ischemia, premature ventricular contractions, ST segment depression, supraventricular tachycardia, tachycardia, ventricular fibrillation, extrasystole, syncope, chest pain, right heart failure

Rare (0.01% to 0.1%): Pulmonary edema, asystole, syncope, perioperative arrhythmias, cardiac arrest

Very rare (less than 0.01%): Cardiac failure

Frequency not reported: Cardiac arrhythmia

Very common (10% or more): Pruritus (28%)

Common (1% to 10%): Transient flush, rash

Uncommon (0.1% to 1%): Conjunctival hyperemia, diaphoresis, urticaria

Common (1% to 10%): Nausea, vomiting

Uncommon (0.1% to 1%): Hypersalivation, cramping, diarrhea, dry mouth, enlarged parotid, nausea, impaired swallowing, vomiting, ileus

Very rare (less than 0.01%): Pancreatitis, abdominal cramps

Uncommon (0.1% to 1%): Urinary retention oliguria

Rare (Less than 0.1%): Discoloration of the urine following prolonged use

Frequency not reported: Hepatomegaly

Rare (0.01% to 0.1%): Anaphylaxis, in some cases with angioedema, bronchospasm, erythema, and hypotension (these reactions have been reported to respond to adrenaline)

Common (1% to 10%): Pain during injection (e.g., burning, tingling/slinging)

Very rare (less than 0.01%): Tissue necrosis following accidental extravascular administration

Uncommon (0.1% to 1%): Hives/itching, phlebitis, redness/discoloration

Uncommon (0.1% to 1%): BUN Increased, creatinine increased, dehydration, hyperglycemia, metabolic acidosis, osmolality increased

Very rare (less than 0.01%): Metabolic acidosis, hyperkalemia, hyperlipidemia

Uncommon (0.1% to 1%): Pain in extremities, trunk pain, whole body weakness, pain in extremities, neck rigidity/stiffness

Very rare (less than 0.01%): Rhabdomyolysis (when administered at doses greater than 4 mg/kg/hour for ICU sedation)

Paresthesias (including burning, tingling, stinging) and/or pruritus, usually manifested in the perineal region, were the most frequently recorded adverse reactions in clinical trials. Paresthesias and pruritus generally occurred within 5 minutes after administration of the initial dose and were generally transient and mild to moderate in intensity. The pharmacologic basis of these sensory phenomena is unknown. No pretreatments, including the use of nonsteroidal anti-inflammatory drugs, opioids, or lidocaine, are known to have an effect on or to reduce the incidence of these sensations.

Very common (10% or more): Paresthesia (74%), excitation phenomena such as involuntary movements, twitches, tremors, hypertonus, hiccup

Common (1% to 10%): Headache, shivering

Rare (0.01% to 0.1%): Convulsions and seizures of the epileptic type

Very rare (less than 0.01%): Postoperative unconsciousness

Frequency not reported: Involuntary movements

Very common (10% or more): Hypoxemia (11%)

Common (1% to 10%): Procedural pain (bronchoscopy), transient apnea, cough, respiratory acidosis during weaning

Uncommon (0.1% to 1%): Bronchospasm, burning in throat, cough, dyspnea, hiccough, hyperventilation, hypoventilation, hypoxia, laryngospasm, pharyngitis, sneezing, tachypnea, upper airway obstruction, apnea

Very rare (less than 0.01%): Pulmonary edema

Very rare (less than 0.01%): Renal failure

Common (1% to 10%): Thrombosis, phlebitis

Uncommon (0.1% to 1%): Hemorrhage, coagulation disorder, leukocytosis

Uncommon (0.1% to 1%): Sepsis

Uncommon (0.1% to 1%): Diplopia, eye pain, nystagmus

Common (1% to 10%): Elation/euphoria

Frequency not reported: Drug abuse and dependence

Uncommon (0.1% to 1%): Fever, anticholinergic syndrome, ear pain, taste perversion, tinnitus