Diphenhydramine Hcl

More frequently reported side effects include: sedated state and thickening of bronchial secretions. See below for a comprehensive list of adverse effects.

Applies to diphenhydramine: oral capsules and tablets, parenteral injection

Side effects include:

Sedation, sleepiness, dizziness, disturbed coordination, epigastric distress, thickening of bronchial secretions.

Applies to diphenhydramine: compounding powder, injectable solution, oral capsule, oral disintegrating strip, oral liquid, oral tablet, oral tablet chewable, oral tablet disintegrating

The most commonly reported side effects included somnolence, dizziness, and incoordination.

Common (1% to 10%): Sedation/somnolence/sleepiness, drowsiness, unsteadiness, dizziness, headache, attention disturbance

Rare (0.01% to 0.1%): Extrapyramidal effects, tremor, convulsions

Frequency not reported: Paresthesia, dyskinesia/muscle dyskinesia, vertigo, neuritis, incoordination, psychomotor impairment, activation of epileptogenic foci

Drowsiness usually diminishes after a few days.

Common (1% to 10%): Dry mouth

Frequency not reported: Gastrointestinal disturbance, nausea, vomiting, constipation, diarrhea, dyspepsia, epigastric distress

Common (1% to 10%): Fatigue

Frequency not reported: Lassitude, tinnitus, acute labyrinthitis, asthenia, chills, impaired performance (including impaired driving, work, and/or information processing)

Rare (0.01% to 0.1%): Confusion, depression, sleep disturbances

Frequency not reported: Paradoxical excitation/excitation, agitation, increased energy, restlessness, nervousness, euphoria, anxiety, hallucinations, insomnia, irritability

Rare (0.01% to 0.1%): Palpitations, hypotension, arrhythmia

Frequency not reported: Tachycardia, chest tightness, extrasystoles

Rare (0.01% to 0.1%): Blood disorders

Frequency not reported: Hemolytic anemia, thrombocytopenia, agranulocytosis

Rare (0.01% to 0.1%): Hypersensitivity reactions

Frequency not reported: Angioedema, anaphylactic shock

Rare (0.01% to 0.1%): Liver dysfunction

Frequency not reported: Rash, urticaria, skin rashes, erythema, photosensitivity, pruritus, drug rash, excessive perspiration

Frequency not reported: Dyspnea, thickening of bronchial secretions, throat tightening, wheezing, nasal stuffiness, dry nose or throat

Frequency not reported: Urinary hesitancy/difficulty/retention, dysuria, early menses

Frequency not reported: Blurred vision, dry eyes, diplopia

Frequency not reported: Increased appetite, anorexia

Frequency not reported: Muscle twitching/weakness