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Diphen

Generic Name: diphenhydramine (DYE fen HYE dra meen)
Brand Names: Allergy Relief, Allermax, Banophen, Benadryl, Compoz Nighttime Sleep Aid, Diphedryl, Diphenhist, Dytuss, Nytol QuickCaps, PediaCare Children's Allergy, Q-Dryl, QlearQuil Nightitme Allergy Relief, Quenalin, Scot-Tussin Allergy Relief Formula, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleepinal, Sominex, Tranquil, Twilite, Unisom Sleepgels Maximum Strength, Valu-Dryl, Vanamine PD, Z-Sleep, ZzzQuil, plus many others
Diphenhydramine is an antihistamine used to treat sneezing, runny nose, itching, hives and other symptoms of allergies and the common cold. Includes diphenhydramine side effects, interactions and indications.
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Drug Information:
Diphenhydramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Diphenhydramine is used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms. Diphenhydramine is also used to treat motion sickness, to induce sleep, and to treat certain symptoms of Parkinson's disease. Diphenhydramine may also be used for purposes not listed in this medication guide. Learn more

Diphen Side Effects

Diphenhydramine Side Effects

In Summary

More frequently reported side effects include: sedated state and thickening of bronchial secretions. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to diphenhydramine: oral capsules and tablets, parenteral injection

Side effects include:

Sedation, sleepiness, dizziness, disturbed coordination, epigastric distress, thickening of bronchial secretions.

For Healthcare Professionals

Applies to diphenhydramine: compounding powder, injectable solution, oral capsule, oral disintegrating strip, oral liquid, oral tablet, oral tablet chewable, oral tablet disintegrating

General

The most commonly reported side effects included somnolence, dizziness, and incoordination.

Nervous system

Common (1% to 10%): Sedation/somnolence/sleepiness, drowsiness, unsteadiness, dizziness, headache, attention disturbance

Rare (0.01% to 0.1%): Extrapyramidal effects, tremor, convulsions

Frequency not reported: Paresthesia, dyskinesia/muscle dyskinesia, vertigo, neuritis, incoordination, psychomotor impairment, activation of epileptogenic foci

Drowsiness usually diminishes after a few days.

Gastrointestinal

Common (1% to 10%): Dry mouth

Frequency not reported: Gastrointestinal disturbance, nausea, vomiting, constipation, diarrhea, dyspepsia, epigastric distress

Other

Common (1% to 10%): Fatigue

Frequency not reported: Lassitude, tinnitus, acute labyrinthitis, asthenia, chills, impaired performance (including impaired driving, work, and/or information processing)

Psychiatric

Rare (0.01% to 0.1%): Confusion, depression, sleep disturbances

Frequency not reported: Paradoxical excitation/excitation, agitation, increased energy, restlessness, nervousness, euphoria, anxiety, hallucinations, insomnia, irritability

Cardiovascular

Rare (0.01% to 0.1%): Palpitations, hypotension, arrhythmia

Frequency not reported: Tachycardia, chest tightness, extrasystoles

Hematologic

Rare (0.01% to 0.1%): Blood disorders

Frequency not reported: Hemolytic anemia, thrombocytopenia, agranulocytosis

Hypersensitivity

Rare (0.01% to 0.1%): Hypersensitivity reactions

Frequency not reported: Angioedema, anaphylactic shock

Hepatic

Rare (0.01% to 0.1%): Liver dysfunction

Dermatologic

Frequency not reported: Rash, urticaria, skin rashes, erythema, photosensitivity, pruritus, drug rash, excessive perspiration

Respiratory

Frequency not reported: Dyspnea, thickening of bronchial secretions, throat tightening, wheezing, nasal stuffiness, dry nose or throat

Genitourinary

Frequency not reported: Urinary hesitancy/difficulty/retention, dysuria, early menses

Ocular

Frequency not reported: Blurred vision, dry eyes, diplopia

Metabolic

Frequency not reported: Increased appetite, anorexia

Musculoskeletal

Frequency not reported: Muscle twitching/weakness

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Diphen (www.drugs.com/diphenhydramine.html).