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Diovan

Generic Name: valsartan (val SAR tan)
Brand Names: Diovan
Diovan is used to treat high blood pressure (hypertension) or heart failure. Learn about side effects, interactions and indications.

Average Savings for valsartan (generic): 71.93%
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Drug Information:
Diovan (Valsartan) is an type of blood pressure medication called an ARB (angiotensin II receptor antagonist). Diovan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Diovan is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. It is sometimes given together with other blood pressure medications. Diovan is also used in adults to treat heart failure, and to lower the risk of death after a heart attack. Do not use Diovan if you are pregnant. Stop using this medicine and tell your doctor right away if you become pregnant. Learn more

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Diovan Side Effects

Note: This document contains side effect information about valsartan. Some of the dosage forms listed on this page may not apply to the brand name Diovan.

In Summary

Common side effects of Diovan include: dizziness and increased serum potassium. Other side effects include: hypotension. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to valsartan: oral tablet

Warning

Oral route (Capsule; Tablet; Solution)

When pregnancy is detected, discontinue valsartan as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

Along with its needed effects, valsartan (the active ingredient contained in Diovan) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking valsartan:

Less common

  • Bloody urine
  • cold sweats
  • confusion
  • decreased frequency or amount of urine
  • difficult breathing
  • dizziness, faintness, or lightheadedness when getting up from a lying position
  • fainting
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • lower back or side pain
  • nausea
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • swelling of the face, fingers, or lower legs
  • unusual tiredness or weakness
  • vomiting
  • weight gain

Rare

  • Chills
  • fever
  • hoarseness
  • sore throat
  • swelling of the mouth, hands, or feet
  • trouble with swallowing or breathing (sudden)

Incidence not known

  • Dark urine
  • general tiredness and weakness
  • light-colored stools
  • upper right abdominal or stomach pain
  • yellow eyes and skin

Some side effects of valsartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Abdominal or stomach pain
  • back pain
  • blurred vision
  • cold or flu-like symptoms
  • coughing
  • diarrhea
  • difficulty with moving
  • headache
  • muscle pain or stiffness
  • pain, swelling, or redness in the joints

Incidence not known

  • Hair loss
  • thinning of the hair

For Healthcare Professionals

Applies to valsartan: oral capsule, oral tablet

Nervous system

Very common (10% or more): Headache (up to 14%), dizziness (up to 14%)

Common (1% to 10%): Dizziness

Uncommon (0.1% to 1%): Vertigo

Respiratory

Common (1% to 10%): Cough

Uncommon (0.1% to 1%): Dyspnea

Hypersensitivity

A 71-year-old woman experienced an acute onset of angioedema and a photosensitive pruritic rash after 3 months of valsartan (the active ingredient contained in Diovan) therapy. Her symptoms dissipated and the rash resolved after treatment with subcutaneous epinephrine, intravenous methylprednisolone, diphenhydramine, and emollient cream.

A unique case of dose-dependent, valsartan-induced angioedema has been reported. Two hours after initiating a dose increase (160 to 320 mg/day) of valsartan, a patient developed angioedema (i.e., swelling of lips and tongue). Symptoms resolved following a reduction in dose to the original dosage of 160 mg/day.

Very rare (less than 0.01%): Angioedema

Cardiovascular

Common (1% to 10%): Symptomatic hypotension in 5.5% of heart failure patients in clinical trials

Rare (less than 0.1%): Palpitations, chest pain

Frequency not reported: Dizziness related to orthostatic hypotension

Postmarketing reports: Heart failure

Metabolic

Common (1% to 10%): Hyperkalemia, hyponatremia

Renal

Frequency not reported: Impaired renal function, increases in serum creatinine concentrations, blood urea nitrogen, and potassium

Postmarketing reports: Renal failure

Dermatologic

Rare (less than 0.1%): Pruritus, rash, alopecia

Postmarketing reports: Bullous dermatitis

Gastrointestinal

Uncommon (0.1% to 1%): Diarrhea, constipation, dry mouth, dyspepsia, anorexia, nausea, vomiting, flatulence

Postmarketing reports: Taste disturbance (i.e., altered sensitivity of basic tastes) has been reported following repeated dosing

Musculoskeletal

Common (1% to 10%): Back pain, muscle cramps, myalgias

Very rare (less than 0.01%): Rhabdomyolysis

Psychiatric

Frequency not reported: Anxiety, insomnia, paresthesias, somnolence

Genitourinary

Very rare (less than 0.01%): Impotence

Hematologic

Uncommon (0.1% to 1%): Hematocrit decreased, hemoglobin decreased, neutropenia

Postmarketing reports: Thrombocytopenia, vasculitis

Hepatic

Valsartan-associated hepatotoxicity in a patient with hepatitis B surface antigen (HBs-Ag) positivity (without signs and symptoms) has been reported. After 1 month of treatment with valsartan (the active ingredient contained in Diovan) this patient developed pruritic erythematous skin changes, nausea, jaundice, right subcostal abdominal pain, elevated liver enzymes, and mild hepatomegaly. Signs and symptoms of hepatotoxicity resolved within 2 to 3 weeks following discontinuation of valsartan and the patient remained asymptomatic after 6 months of follow-up.

Very rare (less than 0.01%): Hepatitis

Frequency not reported: Hepatic enzymes increased

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Diovan (www.drugs.com/diovan.html).