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Note: This document contains side effect information about adapalene topical. Some of the dosage forms listed on this page may not apply to the brand name Differin.
For the ConsumerApplies to adapalene topical: topical cream, topical gel/jelly, topical lotion
Along with its needed effects, adapalene topical (the active ingredient contained in Differin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking adapalene topical:
More common
- especially during the first month of useSome side effects of adapalene topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Rare
- more common during the first month of useFor Healthcare Professionals
Applies to adapalene topical: topical cream, topical gel, topical lotion, topical solution, topical swab
DermatologicPruritus, erythema, scaling, dryness, irritation, sunburn, and acne flares usually occurred during the first month of therapy and decreased thereafter. These side effects were reversible when treatment was discontinued.
Skin exfoliation was associated with skin exposed to mechanical abrasion (e.g., waxing).
Very common (10% or more): Persistent pruritus (up to 74%), persistent burning/stinging (up to 71%), erythema (up to 60%), scaling (up to 60%), pruritus (up to 60%), dryness (up to 48%), pruritus immediately after administration (up to 30%), skin stinging or burning (up to 22%)
Common (1% to 10%): Skin irritation, sunburn
Uncommon (0.1% to 1%): Contact dermatitis/eczema, dermatitis, skin discomfort/pain, skin exfoliation, acne/acne flares, skin swelling
Postmarketing reports: Allergic dermatitis/allergic contact dermatitis, rash, eczema, skin discoloration
LocalVery common (10% or more): Burning (up to 60%); burning immediately after application (up to 30%)
Frequency not reported: Burning/stinging
Burning and stinging usually occurred during the first month of therapy and decreased thereafter. These side effects were reversible when treatment was discontinued.
RespiratoryCommon (1% to 10%): Pharyngitis, rhinitis, sinusitis
GenitourinaryCommon (1% to 10%): Dysmenorrhea
OcularUncommon (0.1% to 1%): Eyelid irritation, eyelid erythema, eyelid pruritus, eyelid swelling/edema
Postmarketing reports: Conjunctivitis
GastrointestinalUncommon (0.1% to 1%): Tooth anomaly, tooth disorder
HypersensitivityRare (0.01% to 0.1%): Allergic reaction
Postmarketing reports: Allergic contact dermatitis/allergic dermatitis
OtherRare (0.01% to 0.1%): Lack of drug effect
Frequency not reported: Flu syndrome
Nervous systemFrequency not reported: Headache
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Differin (www.drugs.com/differin.html).
January 19, 2022
July 26, 2021
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September 2, 2020