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Diclegis

Generic Name: doxylamine and pyridoxine (dox IL a meen and PIR i DOX een)
Brand Names: Bonjesta, Diclegis
Diclegis (doxylamine and pyridoxine) is used to treat nausea and vomiting in pregnancy. Includes Diclegis side effects, interactions and indications.
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Drug Information:
Diclegis is a delayed-release tablet containing a combination of doxylamine and pyRidoxine. Doxylamine is an antihistamine that reduces the effects of natural chemical histamine in the body. PyRidoxine is a form of vitamin B (B6). Diclegis is used to treat nausea and vomiting during pregnancy, sometimes called morning sickness. Diclegis may also be used for purposes not listed in this medication guide. Do not use Diclegis if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, Linezolid, Methylene Blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Learn more

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Diclegis Side Effects

Note: This document contains side effect information about doxylamine / pyridoxine. Some of the dosage forms listed on this page may not apply to the brand name Diclegis.

In Summary

Common side effects of Diclegis include: drowsiness. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to doxylamine / pyridoxine: oral tablet delayed release, oral tablet extended release

Along with its needed effects, doxylamine/pyridoxine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking doxylamine / pyridoxine:

Incidence not known

  • Blurred or loss of vision
  • burning feeling while urinating
  • chest discomfort
  • decrease in the frequency of urination
  • decrease in urine volume
  • difficult or labored breathing
  • difficult or painful urination
  • disturbed color perception
  • double vision
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • halos around lights
  • headache, severe and throbbing
  • hives, itching, skin rash
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • night blindness
  • overbright appearance of lights
  • redness of the skin
  • stomach distension or pain
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • tunnel vision

Some side effects of doxylamine / pyridoxine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Unusual drowsiness

Incidence not known

  • Anxiety
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • confusion about identity, place, and time
  • constipation
  • diarrhea
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • general feeling of discomfort or illness
  • headache
  • increased sweating
  • irritability
  • nightmares
  • sensation of spinning
  • trouble sleeping
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to doxylamine / pyridoxine: oral delayed release tablet, oral tablet extended release

Cardiovascular

Postmarketing reports: Palpitation, tachycardia

Dermatologic

Postmarketing reports: Hyperhidrosis, pruritus, rash, maculo-papular rash

Gastrointestinal

Postmarketing reports: Abdominal distension, abdominal pain, constipation, diarrhea

Hypersensitivity

Postmarketing reports: Hypersensitivity

Nervous system

Very common (10% or more): Somnolence (14.3%)

Postmarketing reports: Vertigo, dizziness, headache, migraines, paresthesia, psychomotor hyperactivity

Ocular

Postmarketing reports: Blurred vision, visual disturbances

Other

Postmarketing reports: Chest discomfort, fatigue, irritability, malaise

Psychiatric

Postmarketing reports: Anxiety, disorientation, insomnia, nightmares

Renal

Postmarketing reports: Dysuria, urinary retention

Respiratory

Postmarketing reports: Dyspnea

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Diclegis (www.drugs.com/diclegis.html).