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Dexrazoxane Prescription
Generic Name: dexrazoxane (dex ray ZOX ane)
Brand Name: Totect, Zinecard
Physician reviewed dexrazoxane patient information - includes dexrazoxane description, dosage and directions.
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Dexrazoxane Drug Information:

Dexrazoxane is used to protect the heart and other tissues from harmful side effects caused by certain cancer medications. The Totect brand of dexrazoxane is used in men or women to treat a condition called extravasation (es-TRA-va-ZAY-shun). Extravasation happens when an injected medicine escapes from the blood vessels and circulates into tissues in the body. Serious tissue damage can occur when extravasation happens during injection of certain cancer medications. The Zinecard brand of dexrazoxane is used to help prevent chemotherapy-related heart problems in women who are receiving doxorubicin for metastatic breast cancer. Zinecard is given only after you have received enough doxorubicin infusions to amount to a certain total dose. Learn more

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Dexrazoxane Side Effects

For the Consumer

Applies to dexrazoxane: intravenous powder for solution

Along with its needed effects, dexrazoxane may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking dexrazoxane:

More common

  • Bluish color
  • changes in skin color
  • chest pain
  • chills
  • cold hands and feet
  • cough
  • difficult or labored breathing
  • fever
  • hoarseness
  • lower back or side pain
  • pain, redness, or swelling in the arm or leg
  • painful or difficult urination
  • pale skin
  • sneezing
  • sore throat
  • swelling of the hands, ankles, feet, or lower legs
  • tenderness
  • tightness in the chest
  • troubled breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Black, tarry stools
  • chest discomfort
  • fast, irregular, or pounding heartbeat
  • pain at the injection site
  • ulcers, sores, or white spots in the mouth

Some side effects of dexrazoxane may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • difficulty having a bowel movement
  • discouragement
  • dizziness
  • feeling sad or empty
  • hair loss
  • headache
  • irritability
  • lack or loss of appetite
  • loss of interest or pleasure
  • muscle pain, spasms, cramps, or stiffness
  • nausea
  • stomach pain
  • thinning of the hair
  • trouble concentrating
  • trouble sleeping
  • vomiting
  • weight loss

For Healthcare Professionals

Applies to dexrazoxane: intravenous powder for injection


Adverse events reported are from clinical trials where patients were also receiving chemotherapy while on this drug, and reflect the combination of this drug, already administered chemotherapy, and the patients underlying condition.


Very common (10% or more): Nausea (77%), vomiting (59%), stomatitis (34%), diarrhea (21%)

Common (1% to 10%): Abdominal pain, constipation, esophagitis, dysphagia


Very common (10% or more): Decreased white blood count (73%), decreased neutrophils (61%) decreased hemoglobin (43%), decreased platelets (23%)

Common (1% to 10%): Anemia


Very common (10% or more): Alopecia (up to 100%)

Common (1% to 10%): Streaking/erythema, urticaria


Very common (10% or more): Injection site pain/discomfort (16%)

Common (1% to 10%): Injection site phlebitis, extravasation


Very common (10% or more): Increased AST (28%), increased ALT (22%)

Common (1% to 10%): Increased LDH, increased alkaline phosphatase

Nervous system

Very common (10% or more): Neurotoxicity (17%), dizziness (11%)

Common (1% to 10%): Headache


Very common (10% or more): Anorexia (42%)

Common (1% to 10%): Increased calcium total, decreased sodium


Very common (10% or more): Infection (23%), sepsis (17%), postoperative infection (16%)

Common (1% to 10%): Pneumonia


Very common (10% or more): Fever (34%), fatigue (61%), pain on injection (13%), edema peripheral (10%)


Very common (10% or more): Increased creatinine (14%)


Common (1% to 10%): Cardiac disorders, phlebitis, hemorrhage


Common (1% to 10%): Depression, insomnia


Common (1% to 10%): Dyspnea, cough

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Dexrazoxane (www.drugs.com/mtm/dexrazoxane.html).