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Desonate Prescription
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Generic Name: desonide topical (DES oh nide)
Brand Names: Desonate
Desonate is used to treat itching caused by allergies, eczema, and psoriasis. Learn about side effects, interactions and indications. Average Savings for desonide (generic): 25.95%
Generic Name: desonide topical (DES oh nide)
Brand Names: Desonate
Desonate is used to treat itching caused by allergies, eczema, and psoriasis. Learn about side effects, interactions and indications. Average Savings for desonide (generic): 25.95%
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1 tablets of Desonate 40 mg
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Desonate Drug Information:

Desonate (Desonide) is a corticosteroid. It prevents the release of substances in the body that cause inflammation. Desonate gel is used to treat mild to moderate atopic dermatitis in patients 3 months of age and older. Treatment should continue for the minimum amount of time as necessary to achieve the desired results. Treatment with Desonate gel should not exceed 4 consecutive weeks. Use Desonate gel exactly as directed on the label, or as it has been prescribed by your doctor. Do not use this medicine in larger amounts or for longer than recommended. Topical steroid medicine can be absorbed through the skin, which may cause steroid side effects throughout the body. Learn more

Desonate Side Effects

Note: This document contains side effect information about desonide topical. Some of the dosage forms listed on this page may not apply to the brand name Desonate.

For the Consumer

Applies to desonide topical: topical application cream, topical application foam, topical application gel/jelly, topical application lotion, topical application ointment

Along with its needed effects, desonide topical (the active ingredient contained in Desonate) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking desonide topical:

Less common

  • Blistering, burning, crusting, dryness, or flaking of the skin
  • burning, itching, redness, skin rash, swelling, or soreness at the application site
  • flushing or redness of the skin
  • irritation
  • itching, scaling, severe redness, soreness, or swelling of the skin
  • peeling of the skin
  • raised, dark red, wart-like spots on the skin, especially when used on the face
  • stinging and burning
  • unusually warm skin

Incidence not known

  • Redness and scaling around the mouth
  • thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (e.g., between the fingers)

Some side effects of desonide topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Body aches or pain
  • chills
  • cough
  • difficulty with breathing
  • ear congestion
  • fever
  • headache
  • loss of voice
  • nasal congestion
  • runny nose
  • sneezing
  • sore throat
  • unusual tiredness or weakness

Less common

  • Cold flu-like symptoms
  • congestion
  • cough
  • hoarseness
  • irritability
  • noisy breathing
  • shortness of breath
  • tender, swollen glands in the neck
  • tightness in the chest
  • trouble with swallowing
  • voice changes
  • wheezing

Incidence not known

  • Acne or pimples
  • burning and itching of the skin with pinhead-sized red blisters
  • burning, itching, and pain in hairy areas, or pus at the root of the hair
  • lightening of normal skin color
  • lightening of treated areas of dark skin
  • reddish purple lines on the arms, face, legs, trunk, or groin

For Healthcare Professionals

Applies to desonide topical: compounding powder, topical cream, topical foam, topical gel, topical kit, topical lotion, topical ointment


The most commonly reported side effects were headache, insomnia, impetigo, skin infection, and rash.


Frequency not reported: Hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome


Postmarketing reports: Allergic reaction including facial edema


Common (1% to 10%): Impetigo, skin infection, rash

Frequency not reported: Folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria

Postmarketing reports: Pruritus, skin disorder


Frequency not reported: Burning, itching, irritation, dryness


Common (1% to 10%): Flu syndrome aggravated

Nervous system

Common (1% to 10%): Headache, insomnia


Frequency not reported: Hyperglycemia, glucosuria, latent diabetes mellitus

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.

Source: Drugs.com Desonate (www.drugs.com/desonate.html).