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Desloratadine Prescription
Generic Name: desloratadine (DES lor A ta deen)
Brand Name: Clarinex, Clarinex Reditabs, Neoclarityn(obsolete), Aerius
Physician reviewed desloratadine patient information - includes desloratadine description, dosage and directions.

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Desloratadine Drug Information:

Desloratadine is an antihistamine that is used to treat the symptoms of allergies, such as sneezing, watery eyes, itching, and runny nose. Desloratadine is also used to treat skin hives and itching in people with chronic skin reactions. Desloratadine may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare prOviders about all your medical conditions, allergies, and all medicines you use. You should not use desloratadine if you are allergic to desloratadine or to loratadine (Claritin). Learn more

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Desloratadine Side Effects

In Summary

More frequently reported side effects include: fatigue, pharyngitis, and nausea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to desloratadine: oral syrup, oral tablet, oral tablet disintegrating

Along with its needed effects, desloratadine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking desloratadine:


  • Anaphylaxis, such as, cough, difficulty swallowing, dizziness, fast heartbeat, hives, itching, puffiness or swelling of eyelids or around the eyes or face or lips or tongue, shortness of breath, skin rash, tightness in chest, unusual tiredness or weakness, wheezing
  • dyspnea, such as, shortness of breath, difficult or labored breathing, tightness in chest, wheezing
  • edema, such as, swelling
  • pruritus, such as, itching skin
  • rash
  • tachycardia, such as, fast, pounding, or irregular heartbeat or pulse
  • urticaria, such as, hives or welts, itching, redness of skin, skin rash.

Some side effects of desloratadine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Headache

Less common

  • Dizziness
  • dry mouth
  • dysmenorrhea, such as, difficult or painful menstruation
  • dyspepsia, such as, acid or sour stomach, belching, heartburn, indigestion, stomach discomfort , upset or pain,
  • fatigue, such as, unusual tiredness or weakness
  • myalgia, such as, joint pain, swollen joints, muscle aching or cramping, muscle pains or stiffness, difficulty in moving
  • pharyngitis, such as, body aches or pain, congestion, cough, dryness or soreness of throat, fever, hoarseness, runny nose, tender swollen glands in neck, trouble in swallowing, voice changes.
  • somnolence, such as, sleepiness or unusual drowsiness
  • nausea

For Healthcare Professionals

Applies to desloratadine: oral solution, oral tablet, oral tablet disintegrating


The most commonly reported side effects included upper respiratory tract infections, diarrhea, fever, and headache.


Upper respiratory tract infections were reported in 21.2% of patients 6 to 11 months of age given oral solution formulations, and coughing was reported in 10.8% of patients 12 to 23 months of age given oral solution formulations.

Very common (10% or more): Upper respiratory tract infections (up to 21.2%), coughing (up to 10.8%)

Common (1% to 10%): Bronchitis, epistaxis, rhinorrhea

Very rare (less than 0.01%): Dyspnea


Very common (10% or more): Diarrhea (up to 19.7%)

Common (1% to 10%): Dry mouth, dyspepsia, nausea, pharyngitis, vomiting

Very rare (less than 0.01%): Abdominal pain

In patients treated for chronic idiopathic urticaria, nausea was reported in up to 5%, pharyngitis was reported in 3%, and dyspepsia was reported in 3% of patients 12 years and older.

Diarrhea was reported in 19.1% of patients 6 to 11 months of age given oral solution formulations.


Fever was reported in 16.9% of patients 12 to 23 months of age given oral solution formulations.

In patients treated for chronic idiopathic urticaria, fatigue was reported in up to 5% of patients 12 years and older.

Very common (10% or more): Fever (up to 16.9%)

Common (1% to 10%): Fatigue

Frequency not reported: Asthenia

Nervous system

Very common (10% or more): Headache (up to 14%)

Common (1% to 10%): Dizziness, somnolence

Very rare (less than 0.01%): Psychomotor hyperactivity, seizures

Postmarketing reports: Dystonia, extrapyramidal symptoms, movement disorder

In patients treated for chronic idiopathic urticaria, headache was reported in up to 14% and dizziness was reported in 4% of patients 12 years and older.

Seizures have been reported in patients with and without seizure disorders.

Movement disorders included dystonia, extrapyramidal symptoms, and tics.


Very common (10% or more): Irritability (up to 12.1%)

Common (1% to 10%): Emotional lability, insomnia

Very rare (less than 0.01%): Hallucinations

Frequency not reported: Abnormal behavior, aggression

Postmarketing reports: Tics

Irritability was reported in 12.1% of patients 6 to 11 months of age given oral solution formulations.

Insomnia was reported in 2.3% of patients 6 to 23 months of age given oral syrup formulations.


Common (1% to 10%): Erythema, rash maculopapular

Very rare (less than 0.01%): Pruritus, rash, urticaria

Frequency not reported: Photosensitivity


Common (1% to 10%): Anorexia, appetite increased

Frequency not reported: Weight increased


Common (1% to 10%): Parasitic infection, varicella


Common (1% to 10%): Dysmenorrhea, urinary tract infection


In patients treated for chronic idiopathic urticaria, myalgia was reported in up to 3%of patients 12 years and older.

Common (1% to 10%): Myalgia


Common (1% to 10%): Otitis media


Very rare (less than 0.01%): Hepatitis, increased bilirubin, liver enzyme elevations

Frequency not reported: Jaundice


Very rare (less than 0.01%): Anaphylaxis, angioedema, hypersensitivity reactions


Very rare (less than 0.01%): Palpitations, tachycardia

Frequency not reported: QT prolongation

Postmarketing reports: Arrhythmia, bradycardia, edema

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Desloratadine (www.drugs.com/mtm/desloratadine.html).