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Depo-Medrol is a steroid that prevents the release of substances in the body that cause inflammation.
Depo-Medrol is used to treat many different inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, gland (endocrine) disorders, and conditions that affect the skin, eyes, lungs, stomach, nervous system, or blood cells.
Depo-Medrol may also be used for purposes not listed in this medication guide.
You may not be able to receive a Depo-Medrol if you have a fungal infection.
You should not be treated with Depo-Medrol if you are allergic to it. You may not be able to receive a this medicine if you have a fungal infection.
Depo-Medrol can weaken your immune system, making it easier for you to get an infection. Steroids can also worsen an infection you already have, or reactivate an infection you recently had. Tell your doctor about any illness or infection you have had within the past several weeks.
Tell your doctor if you have ever had:
heart disease, high blood pressure;
a thyroid disorder;
diabetes;
glaucoma or cataracts;
kidney disease;
cirrhosis or other liver disease;
seizures, epilepsy or recent head injury;
past or present tuberculosis;
herpes infection of the eyes;
a condition called scleroderma;
stomach ulcers, ulcerative colitis, diverticulitis, or recent intestinal surgery;
a parasite infection that causes diarrhea (such as threadworms);
mental illness or psychosis;
osteoporosis or low bone mineral density (steroid medication can increase your risk of bone loss);
a muscle disorder such as myasthenia gravis; or
an electrolyte imbalance (such as low levels of potassium in your blood).
It is not known whether Depo-Medrol will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
You should not breast-feed while using Depo-Medrol.
Depo-Medrol is injected into a muscle or soft tissue, into a skin lesion, into the space around a joint, or given as an infusion into a vein. A healthcare provider will give you this injection.
Steroid medication can weaken your immune system, making it easier for you to get an infection. Call your doctor if you have any signs of infection (fever, chills, body aches).
If you have major surgery or a severe injury or infection, your Depo-Medrol dose needs may change. Make sure any doctor caring for you knows you are using this medicine.
If you use this medicine long-term, you may need medical tests and vision exams.
Call your doctor for instructions if you miss an appointment for your Depo-Medrol.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Do not receive a "live" vaccine while using Depo-Medrol. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chickenpox or measles. These conditions can be serious or even fatal in people who are using Depo-Medrol.
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
blurred vision, tunnel vision, eye pain, or seeing halos around lights;
shortness of breath (even with mild exertion), swelling, rapid weight gain;
severe depression, changes in personality, unusual thoughts or behavior;
new or unusual pain in an arm or leg or in your back;
severe pain in your upper stomach spreading to your back, nausea and vomiting;
bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
a seizure (convulsions); or
low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.
Depo-Medrol can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using Depo-Medrol.
Common side effects may include:
weight gain (especially in your face or your upper back and torso);
slow wound healing;
muscle pain or weakness;
thinning skin, increased sweating;
stomach discomfort, bloating;
headache; or
changes in your menstrual periods.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Many drugs can affect Depo-Medrol. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Depo-medrol (www.drugs.com/mtm/depo-medrol-injection.html).
Note: This document contains side effect information about methylprednisolone. Some of the dosage forms listed on this page may not apply to the brand name Depo-Medrol.
Applies to methylprednisolone: oral tablet
Other dosage forms:
Along with its needed effects, methylprednisolone (the active ingredient contained in Depo-Medrol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking methylprednisolone:
Incidence not known
Some side effects of methylprednisolone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Applies to methylprednisolone: compounding powder, injectable powder for injection, injectable suspension, oral tablet
The most commonly occurring side effects have included fluid retention, alteration in glucose tolerance, increased blood pressure, behavioral and mood changes, increased appetite, and weight gain; the incidence generally correlates with dosage, timing of administration, and duration of treatment.
Frequency not reported: Allergic or hypersensitivity reactions; anaphylactoid reaction, anaphylaxis, angioedema, bronchospasm
A European review describes cases of allergic reactions, including bronchospasm and anaphylaxis, in patients allergic to cows milk proteins receiving injectable methylprednisolone products containing lactose of bovine origin. In most cases, the patients were younger than 12 years old and had childhood asthma. In some cases, the reaction was mistaken as lack of efficacy, and additional doses of were give with subsequent worsening of the patients condition. The European Union has recommended lactose-containing methylprednisolone products be reformulated to remove any trace of milk proteins by 2019.
Frequency not reported: Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis, edema, hypotension
Frequency not reported: Cushingoid state, hirsutism, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery, or illness), moon face
Frequency not reported: Abdominal distention, nausea, pancreatitis, peptic ulcer, perforation of the small and large intestine, ulcerative esophagitis, gastric hemorrhage, vomiting, abdominal pain, diarrhea, dyspepsia, nausea
Reversible transaminase elevations (AST, ALT) have been observed following corticosteroid therapy. These changes have generally been small and not associated with any clinical syndrome. Toxic hepatitis has been reported with high doses of cyclically pulsed IV therapy, onset has been several weeks or longer. Resolution has been reported with discontinuation; however, recurrence has been reported with rechallenge.
Frequency not reported: Hepatomegaly, elevation in liver enzymes, toxic hepatitis
Frequency not reported: Decreased carbohydrate and glucose tolerance, manifestations of latent diabetes, hypokalemic alkalosis, potassium loss, sodium retention, increased appetite, negative nitrogen balance due to protein catabolism, weight gain, metabolic acidosis, dyslipidemia, lipomatosis
Frequency not reported: Suppression of growth in pediatric patients, aseptic necrosis of femoral and humeral heads, calcinosis, Charcot-like atrophy, loss of muscle mass, muscle weakness, osteoporosis, pathologic fracture of long bones, postinjection flare, steroid myopathy, tendon rupture, particularly of the Achilles tendon, vertebral compression fractures, myalgia, muscle atrophy, osteonecrosis, neuropathic arthralgia, growth retardation
Frequency not reported: Leucocytosis
Frequency not reported: Opportunistic infection
Frequency not reported: Exophthalmos, glaucoma, increased intraocular pressure, posterior subcapsular cataracts, blindness, chorioretinopathy
Blindness has been reported with corticosteroid injection to scalp, tonsillar fauces, sphenopalatine ganglion.
Frequency not reported: Depression, emotional instability, euphoria, insomnia, mood swings, personality changes, psychic disorders, confusional states, anxiety, abnormal behavior, irritability
Frequency not reported: Acne, allergic dermatitis, cutaneous and subcutaneous atrophy, dry scaly skin, ecchymosis, petechiae, erythema, hyperpigmentation, hypopigmentation, impaired wound healing, increased sweating, rash, sterile abscess, striae, suppressed reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria, hypertrichosis, angioedema, skin atrophy, hyperhidrosis, pruritus
Frequency not reported: Injection site infections, injection site reactions
Frequency not reported: Convulsions, headache, increased intracranial pressure with papilledema (pseudotumor cerebri) usually following discontinuation of treatment, neuritis, neuropathy, paresthesia, amnesia, dizziness
Frequency not reported: Vertigo, abnormal fat deposits, malaise, sterile abscess, impaired healing, fatigue
Frequency not reported: Kaposi's sarcoma
Frequency not reported: Pulmonary edema, pulmonary embolism, hiccups
Frequency not reported: Menstrual irregularities, increased or decreased motility and number of spermatozoa, increased urine calcium, glycosuria
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Depo-medrol (www.drugs.com/mtm/depo-medrol-injection.html).
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