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Decitabine

Generic Name: decitabine (de SIT a been)
Brand Name: Dacogen
Physician reviewed decitabine patient information - includes decitabine description, dosage and directions.
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Drug Information:
Decitabine is a cancer medicine that is used to treat myelodysplastic syndromes (certain types of blood or bone marrow cancer). Decitabine may also be used for purposes not listed in this medication guide. Decitabine affects your immune system. You may get infections more easily. Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, chills, cough, sore throat, trouble breathing). Tell your doctor if you have ever had: kidney disease; or liver disease. Decitabine can harm an unborn baby or cause birth defects if the mother or the father is using decitabine. Learn more

Decitabine Side Effects

Decitabine Side Effects

In Summary

Commonly reported side effects of decitabine include: neutropenia and thrombocytopenia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to decitabine: intravenous powder for solution

Along with its needed effects, decitabine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking decitabine:

More common

  • Black, tarry stools
  • bladder pain
  • bleeding after defecation
  • bleeding gums
  • blood in urine or stools
  • bloody or cloudy urine
  • blue lips and fingernails
  • blurred vision
  • body aches or pain
  • chest pain
  • chills
  • coma
  • congestion
  • convulsions
  • cough
  • coughing that sometimes produces a pink frothy sputum
  • decreased urination
  • difficult, burning, or painful urination
  • difficult, fast, noisy breathing, sometimes with wheezing
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
  • drowsiness
  • dry mouth
  • dryness of throat
  • facial swelling
  • fainting
  • fast or irregular heartbeat
  • feeling unusually cold
  • fever
  • flushed, dry skin
  • frequent urge to urinate
  • fruit-like breath odor
  • headache
  • hives or welts
  • hoarseness
  • increased hunger
  • increased sweating
  • increased thirst
  • increased urination
  • itching, pain, redness, swelling, tenderness, or warmth on skin
  • lightheadedness
  • loss of appetite
  • lower back or side pain
  • mood or mental changes
  • muscle pain or cramps
  • muscle spasms or twitching
  • nausea or vomiting
  • nervousness
  • numbness or tingling in hands, feet, or lips
  • pale skin
  • pinpoint red spots on skin
  • redness or pain at the catheter site
  • runny nose
  • seizures
  • shivering
  • shortness of breath
  • skin rash
  • small clicking, bubbling, or rattling sounds in the lung when listening with a stethoscope
  • small red or purple spots on skin, lips or in mouth
  • sneezing
  • sore mouth or tongue
  • sore throat
  • sores, ulcers, or white spots on lips or in mouth
  • stomach pain and bloating
  • sunken eyes
  • swelling of face, hands, ankles, feet, or lower legs
  • swollen, painful, or tender lymph glands in neck, armpit, or groin
  • tightness in chest
  • trembling
  • trouble in swallowing
  • troubled breathing with exertion
  • uncomfortable swelling around anus
  • unexplained weight loss
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • voice changes
  • weakness or heaviness of legs
  • wheezing
  • white patches in mouth and/or on tongue
  • wrinkled skin
  • yellow eyes or skin

Less common

  • Collection of blood under skin
  • deep, dark purple bruise
  • diarrhea
  • pain or tenderness around eyes and cheekbones
  • pain, warmth, or burning in fingers, toes, and legs
  • problems with vision or hearing
  • skin scrape or burn
  • stuffy nose
  • swelling at injection site

Some side effects of decitabine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acid or sour stomach
  • anxiety
  • back pain
  • belching
  • bumps on skin
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest discomfort
  • constipation
  • difficulty swallowing
  • fall
  • hair loss, thinning of hair
  • heartburn
  • indigestion
  • loose stools
  • muscle stiffness
  • pain in arms or legs
  • pain in joints
  • sleeplessness
  • stomach discomfort or upset
  • swelling or inflammation of the mouth
  • trouble sleeping
  • unable to sleep
  • unusual drowsiness, dullness, or feeling of sluggishness

Less common

  • Difficulty in moving
  • general feeling of discomfort or illness
  • muscle aching
  • pain in the tongue
  • postnasal drip
  • pressure in the stomach
  • swollen joints

For Healthcare Professionals

Applies to decitabine: intravenous powder for injection

Hematologic

Very common (10% or more): Neutropenia (90%), thrombocytopenia (89%), anemia (68%), febrile neutropenia (29%), leukopenia (28%), lymphadenopathy (12%)

Common (1% to 10%): Thrombocythemia

Uncommon (0.1% to 1%): Pancytopenia

Gastrointestinal

Very common (10% or more): Nausea (42%), constipation (35%), diarrhea (34%), vomiting (25%), abdominal pain (14%), oral mucosal petechiae (13%), stomatitis (12%), dyspepsia (12%), ascites (10%)

Common (1% to 10%): Gingival bleeding, hemorrhoids, loose stools, tongue ulceration, dysphagia, oral soft tissue disorder, lip ulceration, abdominal distension, upper abdominal pain, gastroesophageal reflux disease, glossodynia

Frequency not reported: Enterocolitis (including neutropenic colitis, cecitis)

Respiratory

Very common (10% or more): Cough (40%), pneumonia (24%), pharyngitis (16%), epistaxis (14%), lung crackles (14%), breath sounds decreased (10%), hypoxia (10%)

Common (1% to 10%): Sinusitis, rales, postnasal drip

Frequency not reported: Interstitial lung disease

Other

Very common (10% or more): Pyrexia (53%), peripheral edema (25%), rigors (22%), edema (18%), pain (13%), lethargy (12%), tenderness (11%), blood alkaline phosphatase increased (11%), blood urea increased (10%)

Common (1% to 10%): Fall, chest wall pain, intermittent pyrexia, malaise, crepitations, blood lactate dehydrogenase increased, blood albumin decreased, blood bicarbonate increased, blood chloride decreased, decreased total protein, blood bilirubin decreased

Metabolic

Very common (10% or more): Hyperglycemia (33%), hypoalbuminemia (24%), hypomagnesemia (24%), hypokalemia (22%), hyponatremia (19%), appetite decreased (16%), anorexia (16%), hyperkalemia (13%)

Common (1% to 10%): Dehydration

Nervous system

Very common (10% or more): Headache (28%), dizziness (18%), hypoesthesia (11%)

Psychiatric

Very common (10% or more): Insomnia (28%), confusion (12%), anxiety (11%)

Immunologic

Very common (10% or more): Bacterial, viral, fungal infections (63%), candida infection (10%)

Common (1% to 10%): Septic shock, sepsis, staphylococcal infection, oral candidiasis, bacteremia

Dermatologic

Very common (10% or more): Ecchymosis (22%), rash (19%), erythema (14%), cellulitis (12%) skin lesion (11%), pruritus (11%)

Common (1% to 10%): Alopecia, urticaria, swelling face

Uncommon (0.1% to 1%): Acute febrile neutrophilic dermatosis (Sweet's syndrome)

Musculoskeletal

Very common (10% or more): Arthralgia (20%), pain in limb (19%), back pain (17%)

Common (1% to 10%): Chest wall pain, musculoskeletal discomfort, myalgia

Cardiovascular

Very common (10% or more): Petechiae (39%), pallor (23%), cardiac murmur (16%)

Common (1% to 10%): Pulmonary edema, hypotension, hematoma

Hepatic

Very common (10% or more): Hyperbilirubinemia (14%)

Hypersensitivity

Common (1% to 10%): Hypersensitivity including anaphylaxis

Ocular

Common (1% to 10%): Blurred vision

Genitourinary

Very common (10% or more): Urinary tract infection (15%)

Common (1% to 10%): Dysuria, urinary frequency

.

Local

Common (1% to 10%): Injection site erythema, injection site pain, injection site swelling

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Decitabine (www.drugs.com/mtm/decitabine.html).