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Danazol

Danazol Prescription
Generic Name: Danazol (DA na zole)
Easy-to-read patient leaflet for Danazol. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Danazol Drug Information:

This is not a list of all drugs or health problems that interact with danazol. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take danazol with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use danazol as ordered by your doctor. Read all information given to you. Follow all instructions closely. Learn more

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Danazol Side Effects

For the Consumer

Applies to danazol: oral capsule

Warning

Oral route (Capsule)

Use of danazol in pregnancy is contraindicated. A sensitive test capable of determining early pregnancy is recommended immediately prior to start of therapy. A nonhormonal method of contraception should be used during therapy. Androgenic effects on the female fetus exposed in utero have been reported. Thromboembolism, thrombotic and thrombophlebitic events have been reported. Experience with long-term therapy is limited. Physician should be alert to the possibility of potentially silent peliosis hepatis and benign hepatic adenoma with long-term use. Determine the lowest dose that will provide adequate protection. Attempt to decrease or withdraw therapy if initiated during exacerbation of hereditary angioneurotic edema due to trauma, stress, or other cause. Several cases of benign intracranial hypertension have been reported. Screen for papilledema and advise to discontinue immediately if symptoms are present.

Along with its needed effects, danazol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking danazol:

For both females and males

Less common

  • Acne
  • dark-colored urine
  • increased oiliness of the hair or skin
  • muscle cramps or spasms
  • rapid weight gain
  • swelling of the feet or lower legs
  • unusual tiredness or weakness

Rare

  • Bleeding gums
  • bloating, pain, or tenderness of the abdomen or stomach
  • blood in the urine
  • burning, numbness, pain, or tingling in all fingers except the smallest finger
  • changes in vision
  • chest pain
  • chills
  • complete or partial numbness or weakness on one side of body
  • cough
  • coughing up blood
  • diarrhea
  • difficulty with speaking
  • difficulty with swallowing
  • discharge from the nipple
  • eye pain
  • fast heartbeat
  • fever
  • headache
  • hives or other skin rash
  • joint pain
  • light-colored stools
  • loss of appetite (continuing)
  • loss of muscle coordination
  • more frequent nosebleeds
  • muscle aches
  • nausea
  • purple- or red-colored, or other spots on the body or inside the mouth or nose
  • restlessness
  • shortness of breath
  • sore throat
  • sweating
  • tingling, numbness, or weakness in the legs, which may move upward to the arms, trunk, or face
  • unusual bruising or bleeding
  • unusual tiredness, weakness, or general feeling of illness
  • vomiting
  • yellow eyes or skin

For females only

More common

  • Decrease in the breast size
  • irregular menstrual periods
  • weight gain

Rare

  • Enlarged clitoris
  • hoarseness or deepening of voice
  • unnatural hair growth

For males only

Rare

  • Changes in semen
  • decrease in the size of the testicles

Some side effects of danazol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For both females and males

Less common

  • Flushing or redness of the skin
  • mood or mental changes
  • nervousness

Rare

  • Increased sensitivity of the skin to sunlight

For females only

Less common

  • Burning, dryness, or itching of the vagina
  • vaginal bleeding

For Healthcare Professionals

Applies to danazol: compounding powder, oral capsule

General

The most commonly reported side effects included acne, edema, and flushing.

Dermatologic

Very common (10% or more): Acne (up to 13%)

Common (1% to 10%): Facial edema, hair loss, hirsutism/mild hirsutism, maculopapular rash, papular rash, petechial rash, purpuric rash, seborrhea, sun sensitivity/sun sensitive rash, sweating, vesicular rash

Uncommon (0.1% to 1%): Pruritus, urticaria

Very rare (less than 0.01%): Erythema multiforme, inflammatory erythematous nodules, skin pigmentation/skin pigmentation change, Stevens-Johnson syndrome

Frequency not reported: Exfoliative dermatitis, rash

Musculoskeletal

Common (1% to 10%): Arthralgia, backache/back pain, extremity pain, fasciculation, joint lock-up, joint swelling, muscle cramps, muscle spasms, muscle tremors, neck pain, spasms/pains

Rare (0.01% to 0.1%): Benign intracranial hypertension, dizziness

Very rare (less than 0.01%): Carpal tunnel syndrome

Frequency not reported: Altered creatine phosphokinase, creatinine phosphokinase increased, joint pain, limb pain

Genitourinary

Common (1% to 10%): Amenorrhea/persistent amenorrhea/prolonged posttherapy amenorrhea, alteration in cycle timing, menstrual disturbances, pelvic pain, spotting, vaginal dryness/irritation

Uncommon (0.1% to 1%): Breast size changes

Rare (0.01% to 0.1%): Hypertrophy of the clitoris

Very rare (less than 0.01%): Abnormalities in semen volume/viscosity/sperm count/motility, hematuria, testicular atrophy

Frequency not reported: Bartholin's cyst, nipple discharge

Psychiatric

Common (1% to 10%): Anxiety, depression/depressed mood, emotional lability, irritability, libido changes, nervousness

Frequency not reported: Sleep disorders

Gastrointestinal

Common (1% to 10%): Constipation, gastroenteritis, indigestion, nausea, vomiting

Rare (0.01% to 0.1%): Pancreatitis

Very rare (less than 0.01%): Epigastric pain

Frequency not reported: Bleeding gums

Respiratory

Common (1% to 10%): Hoarseness, pitch deepening/instability, sore throat, voice change

Uncommon (0.1% to 1%): Nasal congestion

Very rare (less than 0.01%): Interstitial pneumonitis, pleuritic pain

Metabolic

Common (1% to 10%): Appetite changes, increased insulin requirements (in patients with diabetes), weight gain

Rare (0.01% to 0.1%): Fluid retention

Frequency not reported: Abnormal glucagon, abnormal glucose tolerance, altered glucose tolerance, altered glucagon, decreased apolipoproteins AI and AII, decreased high density lipoprotein cholesterol, increased total cholesterol/low density lipoprotein cholesterol, induction of amino levulinic acid synthetase

Cardiovascular

Common (1% to 10%): Edema, flushing

Rare (0.01% to 0.1%): Arterial thrombosis, blood pressure elevation, hypertension/hypertension exacerbation, palpitation/palpitation exacerbation, tachycardia/tachycardia exacerbation, thrombotic events

Frequency not reported: Myocardial infarction

Nervous system

Common (1% to 10%): Headache

Rare (0.01% to 0.1%): Faintness, vertigo, tremor

Very rare (less than 0.01%): Epilepsy aggravation, migraine/migraine provocation

Frequency not reported: Benign intracranial hypertension, cerebrovascular thrombosis, convulsions, dizziness, Guillain-Barre syndrome, paresthesia, sagittal sinus thrombosis

Other

Common (1% to 10%): Fever

Rare (0.01% to 0.1%): Fatigue, weakness

Frequency not reported: Altered plasma proteins, chills, fasciculation

Hepatic

Uncommon (0.1% to 1%): Hepatic dysfunction

Rare (0.01% to 0.1%): Cholestatic jaundice, hepatic adenoma

Very rare (less than 0.01%): Malignant hepatic tumor, peliosis hepatitis

Frequency not reported: Benign hepatic adenomata, hepatic failure, hepatocellular focal nodular hyperplasia, hepatocellular injury, hepatocellular jaundice, increased AST, jaundice, serum transaminase level increases, reversible elevated serum enzymes

Hematologic

Rare (0.01% to 0.1%): Increased platelet count, increased red cell count, leukopenia, polycythemia/reversible polycythemia, thrombocytopenia

Very rare (less than 0.01%): Eosinophilia/reversible eosinophilia, reversible erythrocytosis, splenic peliosis

Frequency not reported: Leukocytosis

Ocular

Rare (0.01% to 0.1%): Blurred vision, difficulty wearing contact lenses, focusing difficulty, refraction disorders requiring correction

Frequency not reported: Cataracts

Endocrine

Frequency not reported: Altered sex hormone binding globulin, blunted cyclical surges of luteinizing hormone (LH), decreased protein bound iodine, decreased thyroid binding globulin and T4, increased T3 uptake, no disturbance of thyroid stimulating hormone/free thyroxine index

Oncologic

Frequency not reported: Malignant liver tumors

Hypersensitivity

Frequency not reported: Hereditary angioedema

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Danazol (www.drugs.com/danazol.html).