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Dacarbazine

Generic Name: dacarbazine (da CKAR ba zeen)
Brand Name: DTIC-Dome
Physician reviewed dacarbazine patient information - includes dacarbazine description, dosage and directions.
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Drug Information:
Dacarbazine is a cancer medication that interferes with the growth and spread of cancer cells in the body. Dacarbazine is used to treat skin cancer (malignant melanoma) and Hodgkin's disease. Dacarbazine may also be used for purposes not listed in this medication guide. Dacarbazine is used to treat skin cancer (malignant melanoma) and Hodgkin's disease. Avoid eating anything for 4 to 6 hours before your injection. This may help prevent severe nausea or vomiting. Dacarbazine can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches). Learn more

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Dacarbazine Side Effects

Dacarbazine Side Effects

For the Consumer

Applies to dacarbazine: powder for solution

Warning

Intravenous route (Powder for Solution)

Hemopoietic depression is the most common toxicity with dacarbazine for injection. Hepatic necrosis has also been reported. Studies have demonstrated this agent to have a carcinogenic and teratogenic effect when used in animals.

Along with its needed effects, dacarbazine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Check with your doctor immediately if any of the following side effects occur while taking dacarbazine:

More common

  • Redness, pain, or swelling at place of injection

Less common

  • Black, tarry stools
  • blood in urine or stools
  • cough or hoarseness, accompanied by fever or chills
  • fever or chills
  • lower back or side pain, accompanied by fever or chills
  • painful or difficult urination, accompanied by fever or chills
  • pinpoint red spots on skin
  • unusual bleeding or bruising

Rare

  • Shortness of breath
  • stomach pain
  • swelling of face
  • yellow eyes or skin

Check with your doctor as soon as possible if any of the following side effects occur while taking dacarbazine:

Rare

  • Sores in mouth and on lips

Some side effects of dacarbazine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Loss of appetite
  • nausea or vomiting (should lessen after 1 or 2 days)

Less common

  • Feelings of uneasiness
  • flushing of face
  • muscle pain
  • numbness of face

This medicine may cause a temporary loss of hair in some people. After treatment with dacarbazine has ended, normal hair growth should return.

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

  • Black, tarry stools
  • blood in urine or stools
  • cough or hoarseness, accompanied by fever or chills
  • fever or chills
  • lower back or side pain, accompanied by fever or chills
  • painful or difficult urination, accompanied by fever or chills
  • pinpoint red spots on skin
  • unusual bleeding or bruising

For Healthcare Professionals

Applies to dacarbazine: intravenous powder for injection

Hematologic

Very common (10% or more): Bone marrow depression (25%)

Common (1% to 10%): Anemia, leukopenia, thrombocytopenia

Rare (less than 0.1%): Pancytopenia, agranulocytosis, blood lactate dehydrogenase (LDH) increased, blood creatinine increased, blood urea increased

Gastrointestinal

Very common (10% or more): Nausea (90%), vomiting (90%)

Rare (less than 0.1%): Diarrhea

Hepatic

Rare (less than 0.1%): Hepatic necrosis due to veno-occlusive disease (VOD) of the liver, Budd-Chiari syndrome (sometimes fatal), hepatic enzymes increased (e.g., alkaline phosphatase, ASAT, ALAT)

Cardiovascular

Rare (less than 0.1%): Facial flushing

Frequency not reported: ECG abnormalities, orthostatic hypotension (may be associated with high doses)

Hypersensitivity

Rare (0.01% to 0.1%): Anaphylaxis

Dermatologic

Uncommon (0.1% to 1%): Alopecia, hyperpigmentation, photosensitivity

Rare (less than 0.1%): Erythema, maculopapular exanthema, urticaria

Frequency not reported: Rash

Local

Rare (less than 0.1%): Application site irritation

Frequency not reported: Severe pain along the vein caused by injection of concentrated solution, extravasation (causing pain, tissue damage, cellulitis), burning sensation

General

Anorexia, nausea, and vomiting are the most frequently reported adverse reactions. Over 90% of patients are affected with the initial few doses. The vomiting lasts 1 to 12 hours and is incompletely and unpredictably palliated with phenobarbital and/or prochlorperazine. Restricting oral intake of food for 4 to 6 hours prior to therapy may help to alleviate these symptoms. The rapid toleration of these symptoms suggests that a CNS mechanism may be involved, and usually these symptoms subside after the first 1 or 2 days.

Immunologic

Uncommon (0.1% to 1%): Infections, influenza-like symptoms

Musculoskeletal

Frequency not reported: Myalgia

Ocular

Common (1% to 10%): Blurred vision

Rare (less than 0.1%): Impaired vision

Metabolic

Very common (10% or more): Anorexia (90%)

Nervous system

Rare (less than 0.1%): Headache, lethargy, malaise, convulsions, facial paresthesia

Psychiatric

Rare (0.01% to 0.1%): Confusion

Renal

Rare (less than 0.1%): Impaired renal function

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Dacarbazine (www.drugs.com/mtm/dacarbazine.html).