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Applies to cytarabine liposomal/daunorubicin liposomal: intravenous powder for solution
Intravenous route (Powder for Solution)
Do not interchange with other DAUNOrubicin- and/or cytarabine-containing productsDAUNOrubicin and cytarabine, liposome has different dosage recommendations than DAUNOrubicin hydrochloride injection, cytarabine injection, DAUNOrubicin citrate liposome injection, and cytarabine liposome injection. Verify drug name and dose prior to preparation and administration to avoid dosing errors.
Along with its needed effects, cytarabine liposomal / daunorubicin liposomal may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking cytarabine liposomal / daunorubicin liposomal:
Some side effects of cytarabine liposomal / daunorubicin liposomal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
For Healthcare Professionals
Applies to cytarabine liposomal / daunorubicin liposomal: intravenous powder for injectionHematologic
Very common (10% or more): Hemorrhage (anal hemorrhage, blood blister, blood urine present, breast hematoma, catheter site bruise, catheter site hemorrhage, CNS hemorrhage, cerebral hematoma, cerebral hemorrhage, coagulopathy, conjunctival hemorrhage, contusion, ecchymosis, enterocolitis hemorrhagic, epistaxis, GI hemorrhage, gingival bleeding, hematemesis, hematochezia, hematoma, hematuria, hemoptysis, intracranial hemorrhage, subcutaneous hemorrhage, urinary tract hemorrhage, hemorrhoidal hemorrhage, lip hematoma/hemorrhage, melena, mouth/mucosal hemorrhage, periorbital hematoma/hemorrhage, pharyngeal hematoma/hemorrhage, post procedural contusion/hematoma/hemorrhage, pulmonary hemorrhage, purpura, rectal hemorrhage, retinal hemorrhage, scleral hemorrhage, scrotal hematoma, skin ulcer hemorrhage, small intestinal hemorrhage, stomatitis hemorrhagic, subdural hematoma/hemorrhage, subgaleal hematoma, tongue hemorrhage, traumatic hematoma, urethral hemorrhage, vaginal hemorrhage, vessel puncture site hemorrhage, vitreous hemorrhage (70%), febrile neutropenia (68%), thrombocytopenia (28%), neutropenia (17%), petechiae (11%)Hypersensitivity
Frequency not reported: Hypersensitivity (including anaphylaxis)Immunologic
Very common (10% or more): Bacteremia (excluding sepsis) (24%), fungal infection (18%), sepsis (excluding fungal) (11%)Local
Very common (10% or more): Catheter/device/injection site reaction (16%)
Frequency not reported: Tissue necrosisMusculoskeletal
Very common (10% or more): Musculoskeletal pain (e.g., arthralgia, back pain, bone pain, coccydynia, limb discomfort, musculoskeletal chest pain, myalgia, neck pain, pain in extremity, jaw pain) (38%)Ocular
Very common (10% or more): Visual impairment (e.g., photophobia, photopsia, photosensitivity reaction, retinal tear, scintillating scotoma, uveitis, vision blurred, visual acuity reduced, visual impairment, vitreous detachment, vitreous floaters) (11%)
Common (1% to 10%): Conjunctivitis, dry eye, eye edema, eye swelling, eye irritation, eye pain, ocular hyperemia, periorbital edema, scleral hyperemiaMetabolic
Very common (10% or more): Decreased appetite (29%), hyponatremia (14%)
Common (1% to 10%): Hypokalemia, hyperbilirubinemia
Frequency not reported: Copper overloadPsychiatric
Very common (10% or more): Sleep disorders (e.g., abnormal dreams, insomnia, nightmare, sleep apnea) (25%), delirium (16%), anxiety (14%)
Common (1% to 10%): HallucinationsGenitourinary
Frequency not reported: Penile edema, scrotal edemaRespiratory
Very common (10% or more): Epistaxis (36%), cough (33%), dyspnea (acute respiratory distress syndrome, acute respiratory failure, bronchospasm, exertional dyspnea, respiratory distress/failure, wheezing) (32%), pneumonia [excluding fungal] (e.g., bacterial, klebsiella, pseudomonas aeruginosa, viral) (26%), upper respiratory tract infection [excluding fungal] (18%), pleural effusion (16%)
Common (1% to 10%): PneumonitisOther
Very common (10% or more): Fatigue/asthenia (32%), pyrexia (17%)
Common (1% to 10%): DeafnessNervous system
Very common (10% or more): Chills (23%)Renal
Very common (10% or more): Renal insufficiency (e.g., azotemia, oliguria, acute/chronic renal failure) (11%)Cardiovascular
Very common (10% or more): Edema (51%), arrhythmia (e.g., supraventricular arrhythmia, atrial fibrillation, atrial flutter, atrial tachycardia, atrioventricular block first/second degree, bradycardia, bundle branch block right, extrasystole, heart rate increased, nodal arrhythmia, sinus arrhythmia/arrest, sinus bradycardia/tachycardia, supraventricular tachycardia, ventricular extrasystole, ventricular tachycardia) (30%), hypotension (20%), nonconduction cardiotoxicity (e.g., acute coronary syndrome, acute endocarditis, acute myocardial infarction, angina pectoris, aortic valve incompetence, cardiac arrest, cardiac failure, cardiac failure congestive, cardiac murmur, cardiogenic shock, cardiomegaly, cardiomyopathy, cytotoxic cardiomyopathy, diastolic dysfunction, dilatation atrial, Dilatation ventricular, Ejection fraction decreased, Endocarditis, Left ventricular dysfunction, mitral valve incompetence, myocardial infarction, pericardial effusion, pericarditis, restrictive cardiomyopathy, right ventricular hypertrophy) (20%), hypertension (18%), chest pain (17%), pleural effusion (16%)Dermatologic
Very common (10% or more): Rash (e.g., dermatitis, dermatitis acneiform, dermatitis allergic, dermatitis contact, eczema, erythema nodosum, exfoliative rash, psoriasis, erythematous, follicular, generalized, macular, maculopapular, papular, pruritic, pustular, skin exfoliation) (54%), pruritus (15%)Gastrointestinal
Very common (10% or more): Nausea (47%), diarrhea/colitis (e.g., cecitis, colitis, enterocolitis, ileitis, neutropenic colitis, enteritis) (45%), mucositis (e.g., anal erosion, anorectal discomfort, duodenitis, gastric ulcer, GI inflammation, gingival pain, gingival swelling, gingivitis, glossodynia, laryngeal inflammation, lip ulceration, mouth ulceration, mucosal inflammation, mucosal ulceration, odynophagia, mouth edema, esophageal ulcer, esophagitis, oral mucosa erosion, oral mucosal blistering, oral mucosal erythema, pharyngeal ulceration, proctalgia, proctitis, rectal ulcer, stomatitis, tongue ulceration, oropharyngeal pain) (44%), constipation (40%), abdominal pain (33%), vomiting (24%), hemorrhoids (11%)
Common (1% to 10%): Dyspepsia
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.
Source: Drugs.com Cytarabine (www.drugs.com/mtm/cytarabine-and-daunorubicin-liposomal.html).
December 16, 2020
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