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Generic Name: cyclopentolate ophthalmic (sye kloe PEN toe late)
Brand Name: Cyclogyl, Cylate
Physician reviewed Cyclogyl patient information - includes Cyclogyl description, dosage and directions.
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Drug Information:
Cyclopentolate relaxes muscles in your eye to dilate (widen) your pupil. Cyclogyl (for the eyes) is used to dilate your pupil in preparation for an eye exam. Cyclogyl may also be used for purposes not listed in this medication guide. You should not receive Cyclogyl if you have angle-closure glaucoma. You should not receive this medicine if you have ever had a severe allergic Reaction to Cyclogyl, or if you have angle-closure glaucoma. To make sure Cyclogyl is safe for you, tell your doctor if you have glaucoma. Learn more

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Cyclogyl Side Effects

Note: This document contains side effect information about cyclopentolate ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Cyclogyl.

For the Consumer

Applies to cyclopentolate ophthalmic: ophthalmic solution

Along with its needed effects, cyclopentolate ophthalmic (the active ingredient contained in Cyclogyl) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking cyclopentolate ophthalmic:

Symptoms of too much medicine being absorbed into the body

  • Clumsiness or unsteadiness
  • confusion
  • constipation, full feeling, passing gas, or stomach cramps or pain
  • fast or irregular heartbeat
  • convulsions (seizures)
  • fever
  • flushing or redness of face
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • passing urine less often
  • skin rash
  • slurred speech
  • swollen stomach (in infants)
  • thirst or dryness of mouth
  • unusual behavior, such as disorientation to time or place, failure to recognize people, hyperactivity, or restlessness, especially in children
  • unusual drowsiness, tiredness, or weakness

Some side effects of cyclopentolate ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

  • Blurred vision
  • burning of eye
  • eye irritation not present before therapy
  • increased sensitivity of eyes to light

For Healthcare Professionals

Applies to cyclopentolate ophthalmic: compounding powder, ophthalmic solution


Local irritation may occur following instillation and the frequency is dependent upon the concentration used.


Frequency not reported: Intraocular pressure increased, burning, photophobia, vision blurred, irritation, hyperemia, conjunctivitis, blepharoconjunctivitis, punctate keratitis, synechiae, redness of eyes, lacrimation, mucus discharge, allergic conjunctivitis, eye pruritus

Postmarketing reports: Mydriasis prolonged, eye irritation, eye pain

Nervous system

Frequency not reported: Ataxia, incoherent speech, hyperactivity, seizure, drowsiness, coma, medullary paralysis, convulsion, somnolence, incoordination, poor balance, tremor

Postmarketing reports: Retrograde amnesia, dizziness, headache


Frequency not reported: Secretion decreased in pharynx/bronchi/nasal passages


Frequency not reported: Tachycardia, vasodilation


Frequency not reported: Skin rash, flushing, dry skin

Postmarketing reports: Erythema


Frequency not reported: Abdominal distention infants, gastrointestinal motility diminished, salivary secretion decreased, sweat gland secretion decreased, necrotizing colitis, gastroenteritis, dry mouth

Postmarketing reports: Nausea, vomiting


Frequency not reported: Urinary retention


Frequency not reported: Restlessness, hallucination, disorientation, failure to recognize people

Postmarketing reports: Confusion, agitation


Postmarketing reports: Hypersensitivity


Frequency not reported: Feeding intolerance


Frequency not reported: Hyperpyrexia, death, vertigo

Postmarketing reports: Pyrexia, fatigue, gait disturbed

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Cyclogyl (www.drugs.com/mtm/cyclogyl.html).