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$42 – $363
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Crestor (rosuvastatin) belongs to a a group of drugs called HMG CoA reductase inhibitors, or "statins." Rosuvastatin is used together with diet to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood).
Crestor is used in adults and children who are at least 8 years old to lower cholesterol and triglycerides in the blood.
Crestor is used in adults to slow the progression of atherosclerosis (a build-up of plaque in blood vessels that can block blood flow).
Crestor is used to lower the risk of stroke, heart attack, and certain other heart complications in men 50 years and older and women 60 years and older who have coronary heart disease or other risk factors.
Crestor is also used to treat hereditary forms of high cholesterol, including the heterozygous type (inherited from one parent) and the homozygous type (inherited from both parents). For the heterozygous type, Crestor can be used in children who are at least 8 years old. For the homozygous type, this medicine can be used in children as young as 7 years old.
Crestor can harm an unborn baby or cause birth defects. Do not use rosuvastatin if you are pregnant.
Before taking Crestor, tell your doctor if you have ever had liver or kidney disease, diabetes, or a thyroid disorder, if you are of Chinese descent, or if you drink more than 2 alcoholic beverages daily.
In rare cases, Crestor can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
You should not take rosuvastatin if you have liver disease, or if you are breast-feeding a baby.
Avoid eating foods that are high in fat or cholesterol. Crestor will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.
There are many other drugs that can increase your risk of serious medical problems if you take them together with Crestor. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
Crestor is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.
You should not take Crestor if you are allergic to rosuvastatin, or if you have:
liver disease/high levels of liver enzymes in your blood; or
if you are pregnant or breast-feeding.
Do not take Crestor if you are pregnant. Rosuvastatin could harm the unborn baby or cause birth defects. Stop taking this medicine and tell your doctor right away if you become pregnant. Use effective birth control to prevent pregnancy while you are taking this medicine.
Rosuvastatin may pass into breast milk and could harm a nursing baby. Do not breastfeed while you are taking this medicine.
To make sure Crestor is safe for you, tell your doctor if you have ever had:
liver problems;
kidney disease;
a thyroid disorder;
a habit of drinking more than 2 alcoholic beverages per day;
if you are of Asian descent; or
if you are 65 or older.
Crestor can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).
People of Asian descent may absorb rosuvastatin at a higher rate than other people which may cause muscle weakness/dysfunction. Make sure your doctor knows if you are Asian. You may need a lower than normal starting dose.
Take Crestor exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Crestor is usually taken once a day, with or without food. Take the medicine at the same time each day.
While using this medicine, you may need frequent blood tests.
Keep using this medicine as directed, even if you feel well. High cholesterol usually has no symptoms. You may need to take Crestor on a long-term basis.
You may need to stop using this medicine for a short time if you have:
uncontrolled seizures;
an electrolyte imbalance (such as high or low potassium levels in your blood);
severely low blood pressure;
a severe infection or illness;
dehydration; or
surgery or a medical emergency.
You should not stop using Crestor unless your doctor tells you to.
Crestor is only part of a treatment program that may also include diet, exercise, and weight control. Follow your doctor's instructions very closely.
Store at room temperature away from moisture, heat, and light.
Usual Adult Dose for Hyperlipoproteinemia:
Initial dose: 5 mg to 10 mg once a day with or without food
Maintenance dose: 5 mg to 40 mg once a day with or without food
Usual Adult Dose for Hyperlipoproteinemia Type IIa (Elevated LDL):
Initial dose: 5 mg to 10 mg once a day with or without food
Maintenance dose: 5 mg to 40 mg once a day with or without food
Usual Adult Dose for Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL):
Initial dose: 5 mg to 10 mg once a day with or without food
Maintenance dose: 5 mg to 40 mg once a day with or without food
Usual Adult Dose for Hyperlipoproteinemia Type IV (Elevated VLDL):
Initial dose: 5 mg to 10 mg once a day with or without food
Maintenance dose: 5 mg to 40 mg once a day with or without food
Usual Adult Dose for Atherosclerosis:
Initial dose: 5 mg to 10 mg once a day with or without food
Maintenance dose: 5 mg to 40 mg once a day with or without food
Usual Adult Dose for Homozygous Familial Hypercholesterolemia:
Initial dose: 20 mg once a day with or without food
Maintenance dose: 20 mg to 40 mg once a day with or without food
Usual Adult Dose for Prevention of Cardiovascular Disease:
Initial dose: 5 mg to 10 mg once a day with or without food Maintenance dose: 5 mg to 40 mg once a day with or without food
Response to therapy should be estimated from preapheresis LDL-C levels.
Usual Geriatric Dose for Hyperlipidemia:
Initial dose: 5 mg once a day with or without food
Maintenance dose: 5 mg to 20 mg once a day with or without food
Usual Pediatric Dose for Heterozygous Familial Hypercholesterolemia:
Pediatric patients 10 to 17 years of age:
Usual dose range: 5 to 20 mg orally once a day with or without food. Doses should be individualized according to the recommended goal of therapy. Adjustments should be made at intervals of 4 weeks or more.
Maximum dose: 20 mg orally once a day
Take the missed dose as soon as you remember. If you are more than 12 hours late, skip the missed dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Avoid eating foods high in fat or cholesterol, or Crestor will not be as effective.
Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.
Avoid using antacids without your doctor's advice. Use only the type of antacid your doctor recommends, and do not take it within 2 hours after taking Crestor. Some antacids can make it harder for your body to absorb rosuvastatin.
Avoid eating foods that are high in fat or cholesterol. Crestor will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.
Get emergency medical help if you have any signs of an allergic reaction to Crestor: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
unexplained muscle pain, tenderness, or weakness;
confusion, memory problems; or
liver problems - upper stomach pain, tiredness, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes).
Common side effects may include:
headache;
weakness;
muscle aches; or
nausea, stomach pain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Using certain other drugs together with Crestor can increase your risk of serious muscle problems. It is very important to tell your doctor about all medicines you use, and those you start or stop using during your treatment with Crestor, especially:
colchicine;
cyclosporine;
another "statin" medicine - atorvastatin, lovastatin, simvastatin, Lipitor, Pravachol, Zocor, Vytorin, and others;
antiviral medicine to treat HIV or hepatitis C - atazanavir, fosamprenavir, lopinavir, ritonavir, simeprevir, tipranavir, and others;
a blood thinner - warfarin, Coumadin, Jantoven;
other cholesterol medications - fenofibrate, gemfibrozil; or
medicines that contain niacin or nicotinic acid - vitamin B3, Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others.
This list is not complete. Other drugs may interact with rosuvastatin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Further informationRemember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Crestor (www.drugs.com/crestor.html).
Note: This document contains side effect information about rosuvastatin. Some of the dosage forms listed on this page may not apply to the brand name Crestor.
In SummaryCommon side effects of Crestor include: myalgia. Other side effects include: asthenia. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to rosuvastatin: oral tablet
Along with its needed effects, rosuvastatin (the active ingredient contained in Crestor) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking rosuvastatin:
Rare
Incidence not known
Some side effects of rosuvastatin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
For Healthcare Professionals
Applies to rosuvastatin: oral capsule, oral tablet
GeneralThe most frequently reported side effects included headache, myalgia, abdominal pain, asthenia, and nausea.
MusculoskeletalVery common (10% or more): Myalgia (up to 12.7%), arthralgia (10.1%)
Rare (less than 0.1%): Myopathy, rhabdomyolysis, myositis
Frequency not reported: Immune-mediated necrotizing myopathy, tendon disorders, creatine phosphokinase increased
GastrointestinalCommon (1% to 10%): Abdominal pain, nausea, constipation
Rare (less than 0.1%): Pancreatitis
Frequency not reported: Diarrhea
Nervous systemCommon (1% to 10%): Headache, dizziness
Very rare (less than 0.01%): Polyneuropathy, memory loss
Postmarketing reports: Cognitive impairment, forgetfulness, amnesia, memory impairment, peripheral neuropathy
HepaticRare (0.01% to 0.1%): Hepatic transaminases/enzymes increased
Very rare (less than 0.01%): Jaundice, hepatitis
Frequency not reported: Bilirubin increased
Postmarketing reports: Fatal hepatic failure, nonfatal hepatic failure
DermatologicUncommon (0.1% to 1%): Rash, pruritus, urticaria
Rare (less than 0.1%): Angioedema
Frequency not reported: Stevens-Johnson syndrome
RenalFrequency not reported: Acute renal failure
GenitourinaryVery rare (less than 0.01%): Hematuria
Frequency not reported: Proteinuria, myoglobinuria, sexual dysfunction
OtherCommon (1% to 10%): Asthenia
Frequency not reported: Edema, glutamyl transpeptidase increased, alkaline phosphatase increased
RespiratoryFrequency not reported: Cough, dyspnea, interstitial lung disease
PsychiatricFrequency not reported: Confusion, depression, insomnia, nightmares, sleep disorders/disturbances
EndocrineVery rare (less than 0.01%): Gynecomastia
Frequency not reported: Thyroid function abnormalities
MetabolicCommon (1% to 10%): Diabetes mellitus
Frequency not reported: Glucose elevated, HbA1c increased
HematologicRare (less than 0.1%): Thrombocytopenia
HypersensitivityRare (less than 0.1%): Hypersensitivity reaction
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Crestor (www.drugs.com/crestor.html).
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