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$42 – $1040
In the Deductible co-pay stage, you are responsible for the full cost of your prescriptions. Your Medicare deductible cannot exceed $360 in 2016.
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Creon (pancrelipase) contains a combination of three enzymes (proteins): lipase, protease, and amylase. These enzymes are normally produced by the pancreas and are important in the digestion of fats, proteins, and sugars.
Creon is used to replace these enzymes when the body does not have enough of its own. Certain medical conditions can cause this lack of enzymes, including cystic fibrosis, chronic inflammation of the pancreas, or blockage of the pancreatic ducts.
Creon may also be used following surgical removal of the pancreas.
Call your doctor at once if you have symptoms of a rare but serious bowel disorder: severe or unusual stomach pain, vomiting, bloating, diarrhea, or constipation.
Do not chew or keep Creon in your mouth. Creon can irritate the inside of your mouth.
To make sure Creon is safe for you, tell your doctor if you have ever had:
kidney disease;
gout;
high blood uric acid levels (called hyperuricemia);
diabetes;
a blockage or scarring in your intestines;
trouble swallowing pills;
lactose intolerance; or
or pork protein allergy.
It is not known whether Creon will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether Creon passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Take Creon exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Do not switch brands of this medicine without your doctor's advice.
Creon should be taken with a meal or snack.
Read all patient information, medication guides, and instruction sheets provided to you. Be especially careful to follow all directions about giving this medicine to a child. Ask your doctor or pharmacist if you have any questions.
Do not crush, chew, or break open a capsule. Swallow the capsule whole with a full glass of water.
Do not hold the pill in your mouth. Creon can irritate the inside of your mouth.
You may open the Creon capsule and sprinkle the medicine into a spoonful of applesauce to make swallowing easier. Swallow the mixture right away without chewing. Do not save for later use.
Do not mix the medicine with infant formula or breast milk. Give Creon prior to each feeding.
Do not inhale the powder from a Creon capsule, or allow it to touch your skin. It may cause irritation, especially to your nose and lungs.
Tell your doctor if you have any changes in weight. Creon doses are based on weight (especially in children and teenagers), and any changes may affect the dose.
Use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Store at room temperature, away from moisture and heat. Keep the medicine container tightly closed.
Your medicine bottle may also include a packet or canister of moisture-absorbing preservative. Keep this packet in the bottle at all times.
Call your doctor if you have any worsening of a long-term pancreas problem.
Take the missed dose with your next meal or snack. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Get emergency medical help if you have signs of an allergic reaction to Creon: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
joint pain or swelling; or
symptoms of a rare but serious bowel disorder - severe or unusual stomach pain, vomiting, bloating, diarrhea, constipation.
Tell your doctor if your child is not growing at a normal rate while using Creon.
Common Creon side effects may include:
stomach pain, gas, upset stomach;
diarrhea, frequent or abnormal bowel movements;
cough;
dizziness or headache; or
weight loss.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Other drugs may interact with Creon, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Creon only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Creon (www.drugs.com/creon.html).
Note: This document contains side effect information about pancrelipase. Some of the dosage forms listed on this page may not apply to the brand name Creon.
More frequent side effects include: headache. See below for a comprehensive list of adverse effects.
Applies to pancrelipase: oral capsule delayed release, oral tablet
Along with its needed effects, pancrelipase (the active ingredient contained in Creon) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking pancrelipase:
Rare
With high doses
With very high doses
With powder dosage form or powder from opened capsules
- if breathed inWith tablets
- if held in the mouthIncidence not known
Some side effects of pancrelipase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Incidence not known
Applies to pancrelipase: oral capsule, oral capsule extended release, oral delayed release capsule, oral powder for reconstitution, oral tablet, oral tablet extended release
The most commonly reported side effects included gastrointestinal complaints, abdominal pain, and headaches.
Bowel stricture formation occasionally occurred in children with cystic fibrosis who received high doses.
Moderate duodenitis and gastritis occurred in a patient with exocrine pancreatic insufficiency due to cystic fibrosis 16 days after completing treatment with 4000 lipase units/gram fat ingested per day for 5 to 6 days, followed by placebo for an additional 5 to 6 days.
Very common (10% or more): Gastrointestinal complaints (up to 32%), abdominal pain (up to 18%)
Common (1% to 10%): Abdominal distention, abdominal pain upper, abnormal feces, anal pruritus, ascites, constipation, diarrhea, dyspepsia, early satiety, flatulence, frequent bowel movements, nausea, vomiting
Uncommon (0.1% to 1%): Abdominal discomfort, bowel stricture formation
Frequency not reported: Duodenitis, fibrosing colonopathy, gastritis, steatorrhea, strictures of the ileocecum
Postmarketing reports: Distal intestinal obstruction syndrome (DIOS)
Very common (10% or more): Headache (up to 15%)
Common (1% to 10%): Dizziness
Postmarketing reports: Dull headache
A dull headache was reported by a patient receiving treatment with ursodeoxycholic acid concomitantly. The event resolved without sequelae after discontinuation of this drug.
Common (1% to 10%): Decreased appetite, hyperglycemia, hypoglycemia, weight decreased
Frequency not reported: Hyperuricemia
Common (1% to 10%): Rash, skin reactions
Frequency not reported: Pruritus/itching, urticaria/hives
Postmarketing reports: Blotchy/red facial rash
Common (1% to 10%): Biliary tract stones, hydrocholecystis
Postmarketing reports: Asymptomatic liver enzyme elevations
Common (1% to 10%): Cough, nasopharyngitis
Postmarketing reports: Asthma
Common (1% to 10%): Contusion, peripheral edema
Common (1% to 10%): Anemia
Frequency not reported: Transient neutropenia with/without clinical sequelae
Common (1% to 10%): Renal cyst
Common (1% to 10%): Irritability
Common (1% to 10%): Viral infection
A patient with a known history of allergy to another pancrelipase (the active ingredient contained in Creon) product developed a mild allergic reaction, including red, blotchy facial rash and itching. The event resolved without sequelae after discontinuation of this drug.
Frequency not reported: Anaphylactic reactions, hypersensitivity
Postmarketing reports: Anaphylaxis, mild allergic reactions, severe allergic reactions
Frequency not reported: Fatigue
Postmarketing reports: Muscle spasm, myalgia
Postmarketing reports: Recurrence of preexisting carcinoma
Postmarketing reports: Blurred vision
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Creon (www.drugs.com/creon.html).
March 28, 2020
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