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Cozaar (losartan) belongs to a group of drugs called angiotensin II receptor antagonists (sometimes called ARB blockers). It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.
Cozaar is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. It is also used to lower the risk of stroke in certain people with heart disease.
Cozaar is also used to slow long-term kidney damage in people with type 2 diabetes who also have high blood pressure.
Do not use Cozaar if you are pregnant, and tell your doctor right away if you become pregnant. Losartan can cause injury or death to the unborn baby during your second or third trimester.
If you have diabetes, do not use Cozaar together with any medication that contains aliskiren (a blood pressure medicine).
You may also need to avoid taking Cozaar with aliskiren if you have kidney disease.
In rare cases, Cozaar can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
You should not use Cozaar if you are allergic to losartan.
Do not use Cozaar if you are pregnant, and tell your doctor right away if you become pregnant. Losartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
To make sure Cozaar is safe for you, tell your doctor if you have:
kidney disease;
liver disease;
congestive heart failure;
an electrolyte imbalance (such as high levels of potassium in your blood);
if you are on a low-salt diet; or
if you are dehydrated.
You should not breast-feed while using Cozaar.
Cozaar is not approved for use by anyone younger than 6 years old.
Take Cozaar exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
You may take Cozaar with or without food.
Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking Cozaar. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure.
Your blood pressure will need to be checked often and you may need other blood and urine tests.
It may take 3 to 6 weeks before your blood pressure is under control. For best results, keep using the medicine as directed. Talk with your doctor if your condition does not improve after 3 weeks of treatment.
If you have high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.
Store at room temperature away from moisture, heat, and light.
Usual Adult Dose for Diabetic Nephropathy:
Initial dose: 50 mg orally once a day
Maximum dose: 100 mg orally once a day
Comments:
-If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day.
-Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks.
Uses:
-Treatment of hypertension.
-To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy.
-Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.
Usual Adult Dose for Hypertension:
Initial dose: 50 mg orally once a day
Maximum dose: 100 mg orally once a day
Comments:
-If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day.
-Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks.
Uses:
-Treatment of hypertension.
-To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy.
-Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.
Usual Pediatric Dose for Hypertension:
6 Years or Older:
Initial dose: 0.7 mg/kg orally once a day (up to 50 mg total)
Comments:
-May be given as a tablet or suspension.
-Doses above 1.4 mg/kg (or 100 mg) daily have not been studied in pediatric patients.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Drinking alcohol can further lower your blood pressure and may increase certain side effects of Cozaar.
Do not use potassium supplements or salt substitutes, unless your doctor has told you to.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Get emergency medical help if you have signs of an allergic reaction to Cozaar: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
a light-headed feeling, like you might pass out;
pain or burning when you urinate;
high potassium level - nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; or
kidney problems - little or no urination, rapid weight gain, painful or difficult urination, swelling in your hands, feet, or ankles.
Common Cozaar side effects may include:
dizziness;
back pain; or
cold symptoms such as stuffy nose, sneezing, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor about all your other medicines, especially:
a diuretic or "water pill";
other blood pressure medications;
lithium; or
NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete. Other drugs may interact with losartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Cozaar only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Cozaar (www.drugs.com/cozaar.html).
Note: This document contains side effect information about losartan. Some of the dosage forms listed on this page may not apply to the brand name Cozaar.
Common side effects of Cozaar include: asthenia, chest pain, diarrhea, fatigue, and hypoglycemia. Other side effects include: hyperkalemia, hypotension, and orthostatic hypotension. See below for a comprehensive list of adverse effects.
Applies to losartan: oral tablet
Oral route (Tablet)
When pregnancy is detected, discontinue losartan as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury or death to the developing fetus.
Along with its needed effects, losartan (the active ingredient contained in Cozaar) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking losartan:
More common
Rare
Incidence not known
Some side effects of losartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Rare
Applies to losartan: oral tablet
The most common adverse reactions were upper respiratory infection and dizziness.
Common (1% to 10%): Nasal congestion, upper respiratory infection, sinusitis, pharyngitis, cough, sinus disorder
Uncommon (0.1% to 1%): Dyspnea
Frequency not reported: Bronchitis, pharyngeal discomfort, epistaxis, rhinitis, respiratory congestion
Common (1% to 10%): Abdominal pain, nausea, diarrhea, dyspepsia
Uncommon (0.1% to 1%): Obstipation, vomiting
Frequency not reported: Constipation, dental pain, dry mouth, flatulence, gastritis
Common (1% to 10%): Muscle cramp, back pain, leg pain, myalgia
Frequency not reported: Arm pain, hip pain, joint swelling, knee pain, musculoskeletal pain, shoulder pain, stiffness, arthralgia, arthritis, fibromyalgia, muscle weakness
Postmarketing reports: Rhabdomyolysis
Common (1% to 10%): Renal impairment, renal failure, BUN increased, serum creatinine increased
Common (1% to 10%): Dizziness, headache, vertigo
Uncommon (0.1% to 1%): Somnolence
Rare (less than 0.1%): Paresthesia, syncope, cerebrovascular accident
Frequency not reported: Ataxia, hypesthesia, memory impairment, migraine, peripheral neuropathy, tremor, taste perversion, tinnitus
Common (1% to 10%): Asthenia/fatigue, edema/swelling, chest pain
Frequency not reported: Facial edema, fever, orthostatic effects
Postmarketing reports: Malaise
Common (1% to 10%): Hyperkalemia, serum potassium increased, hypoglycemia
Frequency not reported: Anorexia, gout
Postmarketing reports: Hyponatremia
Common (1% to 10%): Orthostatic hypotension
Uncommon (0.1% to 1%): Palpitation, angina pectoris
Rare (less than 0.1%): Atrial fibrillation
Frequency not reported: Second degree atrioventricular block, hypotension, myocardial infarction, sinus bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation, flushing
Postmarketing reports: Vasculitis
Common (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Sleep disorder
Frequency not reported: Anxiety, anxiety disorder, confusion, depression, dream abnormality, libido decreased, nervousness, panic disorder
Common (1% to 10%): Anemia
Rare (less than 0.1%): Hemolysis
Postmarketing reports: Thrombocytopenia, hemoglobin decreased, hematocrit decreased
Uncommon (0.1% to 1%): Urticaria, pruritus, rash
Rare (less than 0.1%): Angioedema, superficial peeling of palms
Frequency not reported: Alopecia, dermatitis, dry skin, ecchymosis, erythema, photosensitivity, sweating
Postmarketing reports: Erythroderma
Rare (less than 0.1%): ALT increased
Postmarketing reports: Hepatitis, liver enzymes increased, serum bilirubin increased, pancreatitis, liver function abnormalities
Frequency not reported: Impotence, nocturia, urinary frequency, urinary tract infection
Frequency not reported: Blurred vision, burning/stinging in the eye, conjunctivitis, visual acuity decreased
Frequency not reported: Flu-like symptoms
Postmarketing reports: Anaphylactic reactions, hypersensitivity reactions
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Cozaar (www.drugs.com/cozaar.html).
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