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Cotellic

Generic Name: cobimetinib (KOE bi ME ti nib)
Brand Names: Cotellic
Cotellic (cobimetinib) is used in combination with vemurafenib to treat advanced melanoma. Includes Cotellic side effects, interactions and indications.
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Drug Information:
Cotellic (cobimetinib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Cotellic is used to treat a certain type of metastatic melanoma (skin cancer) that has spread to other parts of the body and cannot be removed with surgery. Cotellic is usually given together with another medicine called vemurafenib (Zelboraf). Cotellic is used only if your tumor has a specific genetic marker, for which your doctor will test. Follow all directions on your medicine label and package. Tell each of your healthcare prOviders about all your medical conditions, allergies, and all medicines you use. Learn more

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Cotellic Side Effects

Note: This document contains side effect information about cobimetinib. Some of the dosage forms listed on this page may not apply to the brand name Cotellic.

In Summary

Common side effects of Cotellic include: skin photosensitivity. Other side effects include: increased creatine phosphokinase in blood specimen. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to cobimetinib: oral tablet

Along with its needed effects, cobimetinib (the active ingredient contained in Cotellic) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cobimetinib:

More common

  • Abdominal or stomach pain or tenderness
  • bleeding gums
  • blurred vision or any other change in vision
  • chest discomfort or pain
  • chills
  • clay colored stools
  • coughing up blood
  • dark urine
  • decreased appetite
  • difficulty in breathing or swallowing
  • dizziness
  • faintness
  • fast irregular or pounding heartbeat
  • fever
  • headache
  • increased menstrual flow or vaginal bleeding
  • increased sensitivity of the skin to sunlight
  • itching or skin rash
  • loss of appetite
  • muscle cramps or spasms
  • muscle pain or stiffness
  • nausea and vomiting
  • nervousness
  • nosebleeds
  • paralysis
  • pounding in the ears
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • redness or other discoloration of the skin
  • seeing flashes or sparks of light
  • seeing floating spots before the eyes, or a veil or curtain appearing across part of vision
  • severe sunburn
  • slow or fast heartbeat
  • swelling of the feet or lower legs
  • unusual tiredness or weakness
  • yellow eyes or skin

Some side effects of cobimetinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acne or pimples
  • diarrhea
  • nausea
  • swelling or inflammation of the mouth
  • vomiting

For Healthcare Professionals

Applies to cobimetinib: oral tablet

General

The most commonly reported adverse reactions (more than 35%) were increased creatinine, increased CPK, lymphopenia, increased AST, increased alkaline phosphatase, increased ALT, hypophosphatemia, anemia, increased gamma-glutamyltransferase, diarrhea, photosensitivity reactions, hypoalbuminemia, nausea, and hyponatremia.

Renal

Very common (10% or more): Increased creatinine (99.6%) Common (1% to 10%)

Musculoskeletal

Very common (10% or more): Increased CPK (79%)

Hepatic

Very common (10% or more): Increased AST (73%), increased alkaline phosphatase (71%), increased ALT (68%), increased gamma-glutamyltransferase (65%)

Frequency not reported: Increased total bilirubin

Hematologic

Very common (10% or more): Lymphopenia (73%), anemia (69%), thrombocytopenia (18%), hemorrhage (e.g., rectal, hemorrhoidal, GI tract, uterine, vaginal, pulmonary, cerebral, subarachnoid, ocular, eye, conjunctival, retinal, reproductive system, melena, hematemesis, hematochezia, gingival bleeding, metrorrhagia, hemorrhagic ovarian cyst, menometrorrhagia, menorrhagia, hemoptysis, subgaleal hematoma, hematuria, epistaxis, contusion, traumatic hematoma, ecchymosis, purpura, nail bed bleeding)

Metabolic

Very common (10% or more): Dehydration, hypophosphatemia (68%), hypoalbuminemia (42%), hyponatremia (38%), hyperkalemia (26%), hypokalemia (25%), hypocalcemia (24%)

Gastrointestinal

Very common (10% or more): Diarrhea (60%), nausea (41%), vomiting (24%), stomatitis (14%)

Dermatologic

Very common (10% or more): Photosensitivity reactions (46%), acneiform dermatitis (16%), alopecia (15%), hyperkeratosis (11%), erythema (10%), maculopapular rash, dermatitis acneiform rash

Other

Very common (10% or more): Pyrexia (28%), hemorrhage (13%), chills (10%) Common (1% to 10%):

Cardiovascular

Very common (10% or more): Decreased LVEF (26%), hypertension (15%)

Ocular

Very common (10% or more): Vision impaired (e.g., vision blurred, visual acuity reduced, visual impairment) (15%), chorioretinopathy (e.g., retinal detachment, detachment of retinal pigment epithelium, detachment of macular retinal pigment epithelium) (13%), retinal detachment (e.g., retinal detachment, detachment of retinal pigment epithelium, detachment of macular retinal pigment epithelium) (12%)

Common (1% to 10%): Serious retinopathy (chorioretinopathy, retinal detachment)

Frequency not reported: Retinal vein occlusion

Oncologic

Common (1% to 10%): Cutaneous squamous cell carcinoma/keratoacanthoma, basal cell carcinoma

Uncommon (0.1% to 1%): Second primary melanoma, non-cutaneous malignancies

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Cotellic (www.drugs.com/cotellic.html).