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Note: This document contains side effect information about colchicine. Some of the dosage forms listed on this page may not apply to the brand name Colcrys.
Common side effects of Colcrys include: diarrhea and nausea. See below for a comprehensive list of adverse effects.
Applies to colchicine: oral capsule, oral tablet
Along with its needed effects, colchicine (the active ingredient contained in Colcrys) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking colchicine:
Get emergency help immediately if any of the following symptoms of overdose occur while taking colchicine:
Symptoms of overdose
Some side effects of colchicine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Applies to colchicine: compounding powder, intravenous solution, oral capsule, oral tablet
The most common adverse reactions have included gastrointestinal symptoms and pharyngolaryngeal pain.
Very common (10% or more): Diarrhea (23%)
Common (1% to 10%): Abdominal cramping, abdominal pain, nausea, vomiting
Frequency not reported: Lactose intolerance, gastrointestinal hemorrhage, paralytic ileus, stomatitis
Gastrointestinal events including diarrhea, nausea, vomiting, and abdominal pain are the most common adverse reactions reported with use of this drug. These events are often the first signs of toxicity and may indicate the need for dose reduction or therapy discontinuation.
Rare (less than 0.1%): Agranulocytosis, thrombocytopenia, aplastic anemia
Postmarketing reports: Myelosuppression, disseminated intravascular coagulation
Rare (less than 0.1%): Peripheral neuritis
Frequency not reported: Sensory motor neuropathy
Rare (less than 0.1%): Myopathy, rhabdomyolysis
Frequency not reported: Elevated CPK, myotonia, muscle weakness, muscle pain
Very rare (less than 0.01%): Hypersensitivity including angioedema
Frequency not reported: Renal damage, bladder spasm, anuria, oliguria
Frequency not reported: elevated AST, elevated ALT, elevated alkaline phosphatase, hepatic damage
Common (1% to 10%): Pharyngolaryngeal pain
Postmarketing reports: Adult respiratory distress syndrome
There have been reports of corneal ulcers refractory to conventional treatment and delayed corneal wound healing following strabismus surgery in patients receiving colchicine (the active ingredient contained in Colcrys) Discontinuation of colchicine therapy resulted in satisfactory wound healing within several days.
Frequency not reported: Delayed corneal wound healing
Rare (less than 0.1%): Alopecia
Very rare (less than 0.01%): Nonthrombocytopenic purpura rashes, rashes, urticaria, dermatoses, dermatitis
Frequency not reported: Maculopapular rash
Frequency not reported: Hypothyroidism
Rare (less than 0.1%): Azoospermia, oligospermia
Frequency not reported: Amenorrhea, dysmenorrhea, hematuria
Frequency not reported: Loss of appetite